Phytochemistry and pharmacological activity of the genus artemisia

Bisht, Dheeraj; Kumar, Deepak; Kumar, Dharmendra; Dua, Kamal; Chellappan, Dinesh Kumar

doi:10.1007/s12272-021-01328-4

Cited by 108 publications

(86 citation statements)

References 323 publications

(341 reference statements)

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“…In East Asian traditional medicine, Artemisia species have been widely used to treat jaundice, liver diseases, and renal failure [ 3 ]. Specialized metabolites biosynthesized by Artemisia species, especially phenolic compounds, exhibit potent bioactivities, including antibiotic, antioxidant, hepatoprotective, and antifibrotic effects [ 4 ]. The Nobel Prize awardee Youyou Tu’s discovery of artemisinin from A .…”

Section: Introductionmentioning

confidence: 99%

Genetic and chemical markers for authentication of three Artemisia species: A. capillaris, A. gmelinii, and A. fukudo

et al. 2022

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The genus Artemisia is an important source of medicines in both traditional and modern pharmaceutics, particularly in East Asia. Despite the great benefits of herbal medicine, quality assessment methods for these medicinal herbs are lacking. The young leaves from Artemisia species are generally used, and most of the species have similar morphology, which often leads to adulteration and misuse. This study assembled five complete chloroplast genomes of three Artemisia species, two accessions of A. gmelinii and A. capillaris, and one A. fukudo. Through comparative analysis, we revealed genomic variations and phylogenetic relationships between these species and developed seven InDel-based barcode markers which discriminated the tested species from each other. Additionally, we analyzed specialized metabolites from the species using LC-MS and suggested chemical markers for the identification and authentication of these herbs. We expect that this integrated and complementary authentication method would aid in reducing the misuse of Artemisia species.

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Section: Introductionmentioning

confidence: 99%

Genetic and chemical markers for authentication of three Artemisia species: A. capillaris, A. gmelinii, and A. fukudo

et al. 2022

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“…A plant or plant component utilized for its aroma, flavor, and/or medicinal characteristics is known as the herb. Herbal medications and phytomedicines are all terms for products manufactured from herbs that are used to preserve or promote wellbeing ( 29 , 30 ). Plant-based medications make up around a quarter of the current Indian pharmacopeia, according to estimates.…”

Section: Herbal Plants Exhibiting Anticancer Activitiesmentioning

confidence: 99%

“…Conventional medicinal herbs are organically existing plant-derived drugs that have been utilized to alleviate disease in local or regional healing traditions with little or no chemical modification ( 31 ). Preventive care, disease control, serious adverse effects associated with synthetic medicines, and inadequate therapeutic choices for critical diseases are some of the factors for using herbal pharmaceuticals ( 22 , 30 ). Tibetan traditional medicine is still somewhat localized in their nation of origin, while others, like Ayurvedic and Chinese traditional medicines, are becoming more widely utilized across the world.…”

Section: Herbal Plants Exhibiting Anticancer Activitiesmentioning

confidence: 99%

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

et al. 2022

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Cancer is a prominent cause of mortality globally, and it becomes fatal and incurable if it is delayed in diagnosis. Chemotherapy is a type of treatment that is used to eliminate, diminish, or restrict tumor progression. Chemotherapeutic medicines are available in various formulations. Some tumors require just one type of chemotherapy medication, while others may require a combination of surgery and/or radiotherapy. Treatments might last from a few minutes to many hours to several days. Each medication has potential adverse effects associated with it. Researchers have recently become interested in the use of natural bioactive compounds in anticancer therapy. Some phytochemicals have effects on cellular processes and signaling pathways with potential antitumor properties. Beneficial anticancer effects of phytochemicals were observed in both in vivo and in vitro investigations. Encapsulating natural bioactive compounds in different drug delivery methods may improve their anticancer efficacy. Greater in vivo stability and bioavailability, as well as a reduction in undesirable effects and an enhancement in target-specific activity, will increase the effectiveness of bioactive compounds. This review work focuses on a novel drug delivery system that entraps natural bioactive substances. It also provides an idea of the bioavailability of phytochemicals, challenges and limitations of standard cancer therapy. It also encompasses recent patents on nanoparticle formulations containing a natural anti-cancer molecule.

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“…Because the pathogenesis of obesity-related metabolic dysfunction is multifactorial and complex, diverse strategies have been employed to hinder its development and manifestations, namely stimulating insulin production in pancreatic beta-cells, inhibiting hepatic glucose output, reducing glucose reabsorption in the kidney, and enhancing peripheral glucose uptake and insulin sensitivity (1). The molecular mechanisms driving these effects include inhibition of ATP-sensitive potassium channels in pancreatic beta-cells to stimulate insulin release, activation of the glucagon-like peptide-1 (GLP-1) receptor or inhibition of dipeptidyl peptidase-4 activity to enhance incretin signaling and lower circulating glucose levels, and activation of the peroxisome proliferator-activated receptorgamma (PPARg) in adipocytes to improve insulin sensitivity in peripheral tissues (2)(3)(4)(5). Type 1 diabetes (T1DM), which represents only about five percent of diabetes mellitus cases, results from the progressive destruction of pancreatic beta-cells and consequent inability to produce insulin.…”

Section: Introductionmentioning

confidence: 99%

“…One such plant, Artemisia scoparia (SCOPA), has a long history of medicinal use in much of Asia and Central Europe to treat liver diseases, inflammatory conditions, and diabetes, among other ailments. The genus Artemisia comprises hundreds of species, some of which are among the most widely used medicinal plants across the world ( 1 , 2 ). Perhaps the best known product of the genus is the anti-malarial drug artemisinin, whose isolation from Artemisia annua was awarded the Nobel Prize for Physiology or Medicine in 2015 ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

et al. 2022

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Botanicals have a long history of medicinal use for a multitude of ailments, and many modern pharmaceuticals were originally isolated from plants or derived from phytochemicals. Among these, artemisinin, first isolated from Artemisia annua, is the foundation for standard anti-malarial therapies. Plants of the genus Artemisia are among the most common herbal remedies across Asia and Central Europe. The species Artemisia scoparia (SCOPA) is widely used in traditional folk medicine for various liver diseases and inflammatory conditions, as well as for infections, fever, pain, cancer, and diabetes. Modern in vivo and in vitro studies have now investigated SCOPA’s effects on these pathologies and its ability to mitigate hepatotoxicity, oxidative stress, obesity, diabetes, and other disease states. This review focuses on the effects of SCOPA that are particularly relevant to metabolic health. Indeed, in recent years, an ethanolic extract of SCOPA has been shown to enhance differentiation of cultured adipocytes and to share some properties of thiazolidinediones (TZDs), a class of insulin-sensitizing agonists of the adipogenic transcription factor PPARγ. In a mouse model of diet-induced obesity, SCOPA diet supplementation lowered fasting insulin and glucose levels, while inducing metabolically favorable changes in adipose tissue and liver. These observations are consistent with many lines of evidence from various tissues and cell types known to contribute to metabolic homeostasis, including immune cells, hepatocytes, and pancreatic beta-cells. Compounds belonging to several classes of phytochemicals have been implicated in these effects, and we provide an overview of these bioactives. The ongoing global epidemics of obesity and metabolic disease clearly require novel therapeutic approaches. While the mechanisms involved in SCOPA’s effects on metabolic, anti-inflammatory, and oxidative stress pathways are not fully characterized, current data support further investigation of this plant and its bioactives as potential therapeutic agents in obesity-related metabolic dysfunction and many other conditions.

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Phytochemistry and pharmacological activity of the genus artemisia

Cited by 108 publications

References 323 publications

Genetic and chemical markers for authentication of three Artemisia species: A. capillaris, A. gmelinii, and A. fukudo

Genetic and chemical markers for authentication of three Artemisia species: A. capillaris, A. gmelinii, and A. fukudo

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

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