Ethnomedicinal plants used for the treatment of neurodegenerative diseases in Himachal Pradesh, India in Western Himalaya

Sharma, Kiran; Verma, Rachna; Kumar, Dinesh; Nepovimová, Eugenie; Kuča, Kamil; Kumar, Ashwani; Raghuvanshi, Disha; Dhalaria, Rajni; Puri, Sunil

doi:10.1016/j.jep.2022.115318

Cited by 15 publications

(8 citation statements)

References 133 publications

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“…However, few drugs are effective in treating NDDs. Therefore, searching for lead compounds with neuroprotective and anti-neuroinflammatory potential is crucial for further development of new and efficacious agents , Hypericum plants produce secondary metabolites with potential therapeutic properties for central nervous system disorders . Moreover, many specialized isolates from Hypericum species exhibit significant neuroprotective and anti-neuroinflammatory activities. − The sesquiterpenes identified herein were thus assessed for their neuroprotective effects against H 2 O 2 -induced injury in rat pheochromocytoma PC-12 cells using the MTT method.…”

Section: Resultsmentioning

confidence: 99%

“…However, few drugs are effective in treating NDDs. Therefore, searching for lead compounds with neuroprotective and anti-neuroinflammatory potential is crucial for further development of new and efficacious agents 30,31 Hypericum plants produce secondary metabolites with potential therapeutic properties for central nervous system disorders. 30 Moreover, many specialized isolates from Hypericum species exhibit significant neuroprotective and anti-neuroinflammatory activities.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Hyperhubeins A–I, Bioactive Sesquiterpenes with Diverse Skeletons from Hypericum hubeiense

et al. 2022

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Nine new sesquiterpenes, hyperhubeins A–I (1–9), and 14 known analogues (10–23) were isolated from the aerial portions of Hypericum hubeiense. Their structures and absolute configurations were determined unambiguously via spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compounds 1–3 possess an unprecedented sesquiterpene carbon skeleton. Further, a plausible biosynthetic pathway from farnesyl diphosphate (FPP) is proposed. The isolated phytochemicals were evaluated for neuroprotective and anti-neuroinflammatory properties in vitro. Compounds 1, 2, 5–8, 14, and 21 displayed notable neuroprotective activity against hydrogen peroxide (H2O2)-induced lesions in PC-12 cells at 10 μM. Additionally, compounds 1, 2, 12, and 13 exhibited inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells, with their IC50 values ranging from 4.92 to 6.81 μM. Possible interactions between these bioactive compounds and inducible nitric oxide synthase (iNOS) were predicted via molecular docking. Moreover, Western blotting indicated that compound 12 exerted anti-neuroinflammatory activity by suppressing LPS-stimulated expression of toll-like receptor-4 (TLR-4) and inhibiting consequent activation of nuclear factor-kappa-B (NF-κB) signaling.

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Section: Resultsmentioning

confidence: 99%

“…However, few drugs are effective in treating NDDs. Therefore, searching for lead compounds with neuroprotective and anti-neuroinflammatory potential is crucial for further development of new and efficacious agents 30,31 Hypericum plants produce secondary metabolites with potential therapeutic properties for central nervous system disorders. 30 Moreover, many specialized isolates from Hypericum species exhibit significant neuroprotective and anti-neuroinflammatory activities.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Hyperhubeins A–I, Bioactive Sesquiterpenes with Diverse Skeletons from Hypericum hubeiense

et al. 2022

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“…Flavonoids are polyphenolic substances isolated from higher plants, mainly obtained from fruits, vegetables, grains and other foods, and are the most ingested polyphenolic compounds. A diet rich in flavonoids helps fight oxidative stress 160 , 161 . Thus far, a variety of flavonoids have been determined to have high antioxidant activity, including gren and black tea ( Camellia sinensis ) polyphenols, anthocyanins, quercetin and others.…”

Section: The Role Of Dietary Antioxidant Suplements In the Prevention...mentioning

confidence: 99%

Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

Jin¹,

Zheng²,

Guo³

et al. 2023

Acta Pharmaceutica Sinica B

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“…[90] In a review of neurodegenerative it is recorded that flavonoids and phenols of V. negundo is key constituent for the treatment of dementia one of neurodegenerative disorder. [91] Some of the studies related to neurodegenerative disorders are mentioned in Table 3.…”

Section: Neurological Diseasementioning

confidence: 99%

“…A β 25–35 alters the antioxidant state and interferes with several cellular signalling pathways in order to cause death in neuronal cells through the activation of apoptotic pathways [90] . In a review of neurodegenerative it is recorded that flavonoids and phenols of V. negundo is key constituent for the treatment of dementia one of neurodegenerative disorder [91] . Some of the studies related to neurodegenerative disorders are mentioned in Table 3.…”

Section: Introductionmentioning

confidence: 99%

Chemical Diversity and Medicinal Potential of Vitex negundo L.: From Traditional Knowledge to Modern Clinical Trials

Sharma,

Radha,

Kumar

et al. 2023

Chemistry & Biodiversity

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In recent times, there has been a resurgence of interest in V. negundo, with numerous ongoing clinical investigations exploring its therapeutic potential and the development of formulations derived from its bioactive constituents. Moreover, the market availability of homoeopathic medicines containing V. negundo highlights its enduring popularity. This review article provides a comprehensive analysis of V. negundo, encompassing its phytochemical composition, traditional uses, ethnomedicinal practices, and pharmacological properties. It explores the wealth of knowledge passed down through generations and the potential relevance of this traditional wisdom in modern healthcare. Additionally, the review presents findings from recent clinical trials, shedding light on the efficacy and safety of V. negundo‐based formulations in various therapeutic contexts. Furthermore, the review delves into the emerging application of nanoparticles in V. negundo‐based pharmaceutics, considering their potential to revolutionize drug delivery and formulation techniques. The incorporation of nanotechnology may enhance the bioavailability and targeted delivery of V. negundo's active compounds, further amplifying its medicinal potency. The amalgamation of traditional knowledge and contemporary scientific evidence underscores the relevance of V. negundo in the field of chemistry and biodiversity, paving the way for its continued exploration as a promising source of health‐promoting compounds.

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Ethnomedicinal plants used for the treatment of neurodegenerative diseases in Himachal Pradesh, India in Western Himalaya

Cited by 15 publications

References 133 publications

Hyperhubeins A–I, Bioactive Sesquiterpenes with Diverse Skeletons from Hypericum hubeiense

Hyperhubeins A–I, Bioactive Sesquiterpenes with Diverse Skeletons from Hypericum hubeiense

Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

Chemical Diversity and Medicinal Potential of Vitex negundo L.: From Traditional Knowledge to Modern Clinical Trials

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