Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

Jin, Feng; Zheng, Youle; Guo, Mingyue; Arés, Irma; Martínez, Marta; López-Torres, Bernardo; Martínez-Larrañaga, María-Rosa; Xu, Wei; Anadón, Arturo; Martínez, María-Aránzazu

doi:10.1016/j.apsb.2023.07.010

Cited by 27 publications

(7 citation statements)

References 358 publications

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“…Moreover, research has demonstrated that the human body can effectively enhance its antioxidant system by consuming natural antioxidants. Thus, finding natural antioxidant active substances through a simple pretreatment process has become a focal point of research ( Feng et al, 2023 ).…”

Section: Bioactive Componentsmentioning

confidence: 99%

A critical review of the bioactive ingredients and biological functions of camellia oleifera oil

Qin,

Shen,

Wei

et al. 2024

Current Research in Food Science

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Section: Bioactive Componentsmentioning

confidence: 99%

A critical review of the bioactive ingredients and biological functions of camellia oleifera oil

Qin,

Shen,

Wei

et al. 2024

Current Research in Food Science

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“…However, most of the carotenoids exhibited poor solubility, which caused great challenges for their delivery across the blood–brain barrier (BBB) in order to realize their neuroprotective characteristics. In recent times, nano-drug delivery systems such as cationic nanoparticles and liposomes have been utilized to enhance the permeability of carotenoids across the BBB [ 57 ]. For example, lutein has been loaded into cationic chitosan nanoparticles and administered through the nose for treating AD [ 58 ].…”

Section: Applications Of Carotenoids In Multiple Fieldsmentioning

confidence: 99%

The Application of Natural Carotenoids in Multiple Fields and Their Encapsulation Technology: A Review

Li,

Zhao,

Zhang

et al. 2024

Molecules

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Carotenoids, which are inherent pigments occurring in plants and microorganisms, manifest a diverse array of vivid hues. Owing to their multifarious health advantages, carotenoids have engendered substantial interest among scholars and consumers alike. Presently, carotenoids are extensively employed in the realms of food, nutrition and health commodities, pharmaceuticals, and cosmetics, rendering them an indispensable constituent of our quotidian existence. Therefore, the objective of this review is to present a succinct and methodical examination of the sources, constituents, and factors influencing formation of carotenoids. Particular attention will be given to encapsulation strategies that maintain intrinsic characteristics, as the growing desire for carotenoids is propelled by individuals’ escalating standards of living. Moreover, the applications of natural carotenoids in multiple fields, including pharmaceutical, food and feed, as well as cosmetics, are discussed in detail. Finally, this article explores the main challenges hindering the future advancement of carotenoids, aiming at facilitating their effective integration into the circular economy.

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“…Interestingly, some of these compounds were found to be able to cross the blood-brain barrier (BBB). Thus, they are also considered particularly suitable to exert all their healthy effects in this body region usually reached with difficulty by drugs [79][80][81][82]. Interestingly, once inside our body, through their digestion and extensive conjugation at the liver and colon levels, these compounds give rise to a variety of metabolites [83].…”

Section: Phecs: Natural Products With Antioxidant Anti-inflammatory A...mentioning

confidence: 99%

Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved

Serini,

Calviello

2024

Antioxidants

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Chemotherapy-induced cognitive impairment or “chemobrain” is a prevalent long-term complication of chemotherapy and one of the more devastating. Most of the studies performed so far to identify the cognitive dysfunctions induced by antineoplastic chemotherapies have been focused on treatment with anthracyclines, frequently administered to breast cancer patients, a population that, after treatment, shows a high possibility of long survival and, consequently, of chemobrain development. In the last few years, different possible strategies have been explored to prevent or reduce chemobrain induced by the anthracycline doxorubicin (DOX), known to promote oxidative stress and inflammation, which have been strongly implicated in the development of this brain dysfunction. Here, we have critically analyzed the results of the preclinical studies from the last few years that have evaluated the potential of phenolic compounds (PheCs), a large class of natural products able to exert powerful antioxidant and anti-inflammatory activities, in inhibiting DOX-induced chemobrain. Several PheCs belonging to different classes have been shown to be able to revert DOX-induced brain morphological damages and deficits associated with learning, memory, and exploratory behavior. We have analyzed the biological and molecular mechanisms implicated and suggested possible future perspectives in this research area.

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Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

Cited by 27 publications

References 358 publications

A critical review of the bioactive ingredients and biological functions of camellia oleifera oil

A critical review of the bioactive ingredients and biological functions of camellia oleifera oil

The Application of Natural Carotenoids in Multiple Fields and Their Encapsulation Technology: A Review

Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved

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