Chemical Diversity and Medicinal Potential of Vitex negundo L.: From Traditional Knowledge to Modern Clinical Trials

Abstract

In recent times, there has been a resurgence of interest in V. negundo, with numerous ongoing clinical investigations exploring its therapeutic potential and the development of formulations derived from its bioactive constituents. Moreover, the market availability of homoeopathic medicines containing V. negundo highlights its enduring popularity. This review article provides a comprehensive analysis of V. negundo, encompassing its phytochemical composition, traditional uses, ethnomedicinal practices, and pharmacological properties. It explores the wealth of knowledge passed down through generations and the potential relevance of this traditional wisdom in modern healthcare. Additionally, the review presents findings from recent clinical trials, shedding light on the efficacy and safety of V. negundo‐based formulations in various therapeutic contexts. Furthermore, the review delves into the emerging application of nanoparticles in V. negundo‐based pharmaceutics, considering their potential to revolutionize drug delivery and formulation techniques. The incorporation of nanotechnology may enhance the bioavailability and targeted delivery of V. negundo's active compounds, further amplifying its medicinal potency. The amalgamation of traditional knowledge and contemporary scientific evidence underscores the relevance of V. negundo in the field of chemistry and biodiversity, paving the way for its continued exploration as a promising source of health‐promoting compounds.

Green Synthesis and Characterization of Silver Nanoparticles Using Azadirachta indica Seeds Extract: In Vitro and In Vivo Evaluation of Anti-Diabetic Activity

“…According to previous literature [47], if the natural compounds coating the nanoparticles are themselves anti-diabetic in nature, a synergistic anti-diabetic potential of the final nanomaterial is observed [48], and Azadirachta indica seeds contain the most potent antidiabetic compounds, such as Azadarachtin, Nimbin, Nimbidin, etc., so that must reveal high anti-diabetic potential; therefore, Azadirachta indica seeds extract-mediated AgNPs are better than those AgNPs reported earlier in the literature [49,50]. Considering the vast potentiality of plants as sources, this work aims to investigate the use of Azadirachta indica seed extract for the biosynthesis of AgNPs, and the synthesized AgNPs were pragmatically characterized and investigated for their anti-diabetic potential.…”