Ethnobotanical, Phytochemical, and Pharmacological Properties of Nepenthes Species: A Review

Sanusi, Shuaibu Babaji; Bakar, Mohd Fadzelly Abu; Mohamed, Maryati; Sabran, Siti Fatimah; Mainasara, Muhammad Murtala

doi:10.22159/ajpcr.2017.v10i11.20050

Cited by 16 publications

(10 citation statements)

References 18 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nepenthes comprise a number of natural and cultivated hybrids and present diverse species development. Many species of Nepenthes are commonly used in herbal medicine in several Southeast Asian countries [8]. Some types of extracts from Nepenthes are known to have anti-bacterial and anti-fungal properties.…”

Section: Introductionmentioning

confidence: 99%

Antiproliferation for Breast Cancer Cells by Ethyl Acetate Extract of Nepenthes thorellii x (ventricosa x maxima)

Ou‐Yang

Tsai

Tang

et al. 2019

IJMS

View full text Add to dashboard Cite

Extracts from the Nepenthes plant have anti-microorganism and anti-inflammation effects. However, the anticancer effect of the Nepenthes plant is rarely reported, especially for breast cancer cells. Here, we evaluate the antitumor effects of the ethyl acetate extract of Nepenthes thorellii x (ventricosa x maxima) (EANT) against breast cancer cells. Cell viability and flow cytometric analyses were used to analyze apoptosis, oxidative stress, and DNA damage. EANT exhibits a higher antiproliferation ability to two breast cancer cell lines (MCF7 and SKBR3) as compared to normal breast cells (M10). A mechanistic study demonstrates that EANT induces apoptosis in breast cancer cells with evidence of subG1 accumulation and annexin V increment. EANT also induces glutathione (GSH) depletion, resulting in dramatic accumulations of reactive oxygen species (ROS) and mitochondrial superoxide (MitoSOX), as well as the depletion of mitochondrial membrane potential (MMP). These oxidative stresses attack DNA, respectively leading to DNA double strand breaks and oxidative DNA damage in γH2AX and 8-oxo-2′deoxyguanosine (8-oxodG) assays. Overall these findings clearly revealed that EANT induced changes were suppressed by the ROS inhibitor. In conclusion, our results have shown that the ROS-modulating natural product (EANT) has antiproliferation activity against breast cancer cells through apoptosis, oxidative stress, and DNA damage.

show abstract

Section: Introductionmentioning

confidence: 99%

Antiproliferation for Breast Cancer Cells by Ethyl Acetate Extract of Nepenthes thorellii x (ventricosa x maxima)

Ou‐Yang

Tsai

Tang

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…Previous study on antioxidant activity of leaf extracts from other species of Nepenthes, namely N. khasiana and N. bicalcarata exhibited decent DPPH scavenging activity by having 10-fold lower of IC 50 values compared to the pitcher extracts (Ismail et al 2015;Sanusi et al 2017). These findings showed that the leaf extracts possessed a greater antioxidant activity compared to the pitcher extracts.…”

Section: Relationship Between Dphh Frap and Tpcmentioning

confidence: 94%

“…Furthermore, hybridisation that is extensive in Nepenthes could also lead to variations and unique phytochemical production (Lätti et al 2011). Traditionally, the Nepenthes plant is commonly used as folk medicine to regulate the menstrual cycle, ease child birth, relieve asthma, treat eye inflammation, gastric ulcer, jaundice, high blood pressure and also as an astringent (Aung et al 2002;Sanusi et al 2017;Thao et al 2016;. Collectively, the pitcher has also been used to cook traditional delicacies (Schwallier et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Pitcher Extracts from Three Nepenthes Species

Rosli¹,

Azizan²,

Goh³

2018

JSM

View full text Add to dashboard Cite

Nepenthes, locally known as 'periuk kera' in Malaysia, is a fascinating species due to uniqueness in their morphology in having pitcher organ for carnivorous diet. The pitcher plant has been used for cooking traditional delicacies and as traditional remedies to treat illness. Hence, this species might possess beneficial health properties. This study aimed to compare the antioxidant activity of the pitcher extracts from Nepenthes ampullaria, Nepenthes rafflesiana and their hybrid, Nepenthes × hookeriana. The samples were extracted using methanol:chloroform:water (3:1:1) via sonication assisted extraction and the extracts were subjected to three different antioxidant assays, namely 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing power (FRAP) and total phenolic content (TPC). Extract from N. ampullaria exhibited the strongest radical scavenging activity (0.148 ± 0.04 mg/mL) with the highest ferric reducing power (0.009 ± 0.003 mg GA/mg dry weight) among the three species, whereas that of N. rafflesiana possessed the highest phenolic content (0.057 ± 0.017 mg GA/mg dry weight). However, the antioxidant capacities of the pitcher extracts were not significantly different (p>0.05) between the three species and were much lower than the gallic acid as a standard reference.

show abstract

“…More recent reports described the use of different species of Nepenthes in phytotherapy (Dhamecha et al 2016). In the folk medicine of India and Southeast Asian countries, they are used in the treatment of leprosy, cholera, night blindness, gastrointestinal discomfort, dysentery, stomachache, and bed-wetting, among other ailments (Sanusi et al 2017). The phytochemical compounds isolated from Nepenthes species include polyphenols, terpenoids, tannins, alkaloids, and steroids (Thanh et al 2015).…”

Section: Introductionmentioning

confidence: 99%

The Morphological and Biochemical Effects of Feeding Hooker's Pitcher with Formica fusca or Calliphora vicina Larvae

Wróbel¹,

Wróbel²,

Przybylska³

et al. 2021

JSM

View full text Add to dashboard Cite

The aim of this study was to determine if feeding Hooker’s pitcher (Nepenthes × hookeriana) with blowfly larvae (Calliphora vicina Rob-Desvoidy) or ants (Formica fusca L.) affected the plant’s biometric and biochemical parameters. The research included measurements of length and width of the laminae and pitchers, and the total contents of the ash, assimilation pigments, polyphenols, and flavonoids. These parameters were measured 30 days after the last feeding. This study demonstrated that feeding the plants with blowfly larvae resulted in increases in the lengths and widths of both the laminae and pitchers. Moreover, the laminae had reduced carotenoid content after feeding with blowfly larvae and ants whereas the pitchers of Hooker’s pitcher had increased chlorophyll and carotenoid content after feeding with blowfly larvae. Feeding Hooker’s pitcher plants with blowfly larvae also resulted in a reduction of the total polyphenol content in the laminae whereas the total flavonoid content increased in both the laminae and pitchers of Hooker’s pitcher. Feeding Nepenthes × hookeriana with insects ensures that their nutritional needs are met and leads to pitchers with good physiological condition.

show abstract

Ethnobotanical, Phytochemical, and Pharmacological Properties of Nepenthes Species: A Review

Cited by 16 publications

References 18 publications

Antiproliferation for Breast Cancer Cells by Ethyl Acetate Extract of Nepenthes thorellii x (ventricosa x maxima)

Antiproliferation for Breast Cancer Cells by Ethyl Acetate Extract of Nepenthes thorellii x (ventricosa x maxima)

Antioxidant Activity of Pitcher Extracts from Three Nepenthes Species

The Morphological and Biochemical Effects of Feeding Hooker's Pitcher with Formica fusca or Calliphora vicina Larvae

Contact Info

Product

Resources

About