Ethnobotanical and antiplasmodial investigation on Guinean Terminalia species

Balde, Alpha Oumar; Baldé, E.S.; Bah, Fatoumata; Camara, A.; Baldé, Mamadou Diouldé; Drame, Aminata Doucoure; Dembele, Fousseyni; Barry, Halimatou; Traoré, Mohamed Sahar; Baldé, A.M.

doi:10.1016/j.sajb.2020.04.006

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…A growing number of studies point to the benefits inherent in secondary metabolites produced by these plants to protect themselves from outside invaders [78]. T. superba, a perennial tree, is believed to belong to this group [6].…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have discovered that the inherent phytochemical constituents found in these traditional plants contribute greatly to their gainful worth in the management of various ailments [79]. Terminalia superba (T. superba) is one of these ethnobotanical plants whose various parts have folkloric claims and uses for the management, treatment, and prevention of various ill health [6]. It is a deciduous tree which can grow up to 45-50 m in height usually straight with up to 120-150 cm in diameter.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of antibacterial, antioxidant, and anti-inflammatory properties of GC/MS characterized methanol leaf extract of Terminalia superba (Combretaceae, Engl. & Diels)

2023

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Background Terminalia superba is a well-known medicinal plant used in folk medicine for the management of various diseases and swelling. Validation of its efficacy in standardized scientific models is lacking. This gap needs to be filled as a way of enhancing modern drug discovery. The aim is to evaluate the antibacterial, antioxidant, and anti-inflammatory properties of T. superba in known and established models. Also, to establish and possibly correlate the established activity with the phytochemicals identified using GC/MS and qualitative methods. Results The result showed a dose-dependent percentage inhibition of DPPH, HO•, and Fe3+ reducing activity. The antibacterial activity showed dose-dependent significant (p < 0.05) inhibition against all the organisms used. The anti-inflammatory activity of METS was confirmed in the carrageenan model with significant (p < 0.05) inhibition of paw volume when compared to control while significantly decreasing (p < 0.05) weight of xylene-induced ear. For instance, after 6 h, there was a reduction of 42%, 33%, and 22% for diclofenac, 200 mg, and 100 mg, respectively, as against 4% in control. The significant (p < 0.05) increase in MDA was attenuated by the treatment with METS dose dependently. Phytochemical assay and GC/MS characterization showed that alkaloids, saponins, phenols, quinone, tannins, coumarins, proteins, flavonoids, and amino acids were dominant with fatty acids accounting for 53%. Others are esters (23%), organic compounds (12%), alkanes (9%), and carboxylic acids (3%). Conclusions T. superba possesses antioxidant, antibacterial, and anti-inflammatory properties which are believed to arise from the secondary metabolites observed in the GC–MS characterization. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of antibacterial, antioxidant, and anti-inflammatory properties of GC/MS characterized methanol leaf extract of Terminalia superba (Combretaceae, Engl. & Diels)

2023

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“…& Diels-Limba. In Dionfo, T. albida and T. macroptera are endemic and widely distributed [15,16]. Worldwide, the Terminalia genus.…”

Section: Nomentioning

confidence: 99%

“…Indeed, the genus Terminalia has received more attention to assess and validate therapeutic potential and clinical use due to its many folk medicinal and traditional applications. Of note, among these properties, antidiabetic, antiobesity, anticancer, anti-inflammatory, antimicrobial, antimalarial, antioxidant, and antitumor activities have been reported in several plant species [15]. T. chebula, a popular herbal remedy in India and South-East Asia, is called the "King of Medicine" in Tibet and is always listed at the top of the list of "Ayurvedic Materia Medica" because of its extraordinary property of healing [26].…”

Section: Nomentioning

confidence: 99%

Malaria in Guinean Rural Areas: Prevalence, Management, and Ethnotherapeutic Investigations in Dionfo, Sub-Prefecture of Labe

et al. 2021

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As part of a validation program of antimalarial traditional recipes, an ethnotherapeutic approach was applied in Dionfo, a meso-endemic Guinean rural area where conventional health facilities are insufficient. A prevalence investigation indicated a malarial burden of 4.26%. Ethnomedical and ethnobotanical surveys led to a collection of 63 plant species used against malaria from which Terminalia albida (Combretaceae) was one of the most cited. Ethnotherapeutic evaluation of a remedy based on T. albida was applied to 9 voluntary patients suffering from uncomplicated malaria. Treatment of 7 to 14 days led to an improvement of clinical symptoms and a complete parasite clearance achievement of 8/9 patients without side effects. In addition to antiplasmodial activity in vitro and in vivo previously described, this study indicates an efficacy to support the antimalarial traditional use of T. albida, which could constitute a first-aid treatment when access to other medicines is delayed in the Dionfo community. Ethnotherapeutical investigation could be a valuable approach to guide subsequent investigations on traditional remedies.

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“…T. macroptera extracts are also reported to have interesting antiprotozoal properties against Trypanosoma brucei brucei 20 . Several studies recently enhanced the data on antimalaria activities of root and stemmed barks and leaves of T. macroptera [21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Chemical analysis and Biological properties of Terminalia macroptera Guill. & Perr. from Eastern Chad

Chahad¹,

Adey²,

Adawaye³

et al. 2021

Mediterr.J.Chem.,

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Based on a previous ethnobotanical survey, Terminalia macroptera Guill. & Perr. was selected as its heartwood is traditionally used for infections treatment and as mosquito repellent in the province of Ouaddai (Chad). In our course for a better knowledge of this medicinal plant which could be developed as phytomedicine, it is of great interest to subsequently characterize the chemical profile and bioactivities of this plant. In the present study we develop an Ultrahigh-performance liquid chromatography with diode array detection coupled to electrospray ionization and quadrupole time-of-flight (UHPLC-DAD-ESI/QTOF) technique to characterized on line potentially bioactive compounds. Thirteen compounds were identified in active extracts and fractions from Terminalia macroptera Guill. & Perr. heartwood, namely gallic and ellagic acids derivatives, 23-O-galloyl-terminolic acid, 23-O-galloyl arjunolic acid, 4,4’-dihydroxy-Z-stilbene-O-rutinoside and 3,5,4’-trihydroxy-Z-stilbene-O-rutinoside. Antibacterial properties were evaluated against sensitive and resistant Staphylococcus aureus strains and antioxidant activities using 1,1-diphenyl-2-picryl-hydrazyl (DPPH). Stilbene derivatives, 23-O-galloyl-terminolic acid and 23-O-galloyl arjunolic acid are newly reported in T. macroptera Guill. & Perr.

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Ethnobotanical and antiplasmodial investigation on Guinean Terminalia species

Cited by 8 publications

References 40 publications

Evaluation of antibacterial, antioxidant, and anti-inflammatory properties of GC/MS characterized methanol leaf extract of Terminalia superba (Combretaceae, Engl. & Diels)

Evaluation of antibacterial, antioxidant, and anti-inflammatory properties of GC/MS characterized methanol leaf extract of Terminalia superba (Combretaceae, Engl. & Diels)

Malaria in Guinean Rural Areas: Prevalence, Management, and Ethnotherapeutic Investigations in Dionfo, Sub-Prefecture of Labe

Chemical analysis and Biological properties of Terminalia macroptera Guill. & Perr. from Eastern Chad

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