Introduction Syria has suffered for nine years of war and there were huge demands for blood during and after the lockdown from Coronavirus disease of 2019 (COVID-19).Methods Online questionnaires were distributed to Social Media groups after two weeks of the 10-week full lockdown to determine blood donation patterns. They also included stress, anger, and COVID-19 distress questions.Results The study included 1423 participants, 899 (63.2%) of which were females. Around 48.5% have donated blood, of which 33.3% donated only once in their lifetime. Not having a good reason to donate blood was the main declared reason for not donating, and obtaining a document was the main reason for donating in (64.8%) of participants who had donated blood. Stress, anger, and being distressed to get infected did not have a crucial effect on blood donation, and its patterns. Losing someone close and being endangered from war were associated with more frequent blood donation in contrast to being distressed from war which was more associated with distress from getting infected.Conclusion Distress from COVID-19 was not the main reason for not donating blood. Spreading the culture of volunteer blood donating is crucial as COVID-19 exposure with blood donation can be avoided.