Ethanol-induced hypothermia and hyperglycemia in genetically obese mice

Haller, Edwin W.; Wittmers, Lorentz E.

doi:10.1016/0024-3205(89)90395-0

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Mild or severe sympathetic nerve stimulation consistently leads to hyperglycemia [24,25]. There have been many reports that stress has a potential to induce hypothermia and hyperglycemia [12][13][14]. An ␣-adrenergic stimulus by the administration of adrenaline induced a similar pattern of hypothermia and hyperglycemia.…”

Section: Discussionmentioning

confidence: 92%

“…In a recent preliminary study, we noticed that restraint stress also induced hypothermia and hyperglycemia in mice. This observation as well as the immunosuppression might be very important because many patients suffering from stress show hypothermia derived from circulation failure (i.e., due to severe constriction of vessels) and hyperglycemia (i.e., one of the causes of diabetes mellitus) [12][13][14]. * Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

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Role of α-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity

et al. 2008

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Role of α-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity

et al. 2008

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“…Hypoproteinemia is a well-known phenomenon that disrupts the morphofunctional integrity of the liver. It is noteworthy that a decrease in albumin levels occurred only in rats of the second experimental group, which suggests that constant illumination causes significant disturbances in the protein-synthesizing function of the liver [ 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

Morphofunctional State and Circadian Rhythms of the Liver under the Influence of Chronic Alcohol Intoxication and Constant Lighting

Kozlova

Kirillov

Makartseva

et al. 2021

IJMS

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A study of the influence of chronic alcohol intoxication, constant illumination and their combined effects on the morphofunctional state of the rat liver and the circadian rhythms (CR) of the studied parameters of the organism was carried out. It was found that both alcohol and constant illumination caused significant changes in the structure of the liver, as well as in the circadian rhythmicity of micromorphometric parameters of hepatocytes, ALT, and total and direct bilirubin rhythms; however, the combined effects of ethanol and constant illumination had the most significant effect on the studied parameters of the organism. These two factors caused disturbances in the circadian rhythms of the micromorphometric parameters of hepatocytes, disruption of the circadian rhythms of total protein, albumin, AST, ALT, and direct and total bilirubin, as well as disturbances in the expression and rhythmicity of the studied clock genes against a background of the development of an inflammatory process in the liver.

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“…Results from our study are important to several experimental approaches involving the genetically obese mouse model for examination of the obese-hyperglycemic syndrome (2,11,25) or for the purpose of investigating aspects of carbohydrate and fat metabolism (3,4,16), for which precise mechanisms remain to be elucidated (1,20).…”

Section: E763mentioning

confidence: 99%

The obese gene is expressed in lean littermates of the genetically obese mouse (C57BL/6Job/ob)

Haller¹,

Wittmers²,

Haller³

et al. 1999

American Journal of Physiology-Endocrinology and Metabolism

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Some individuals of the mixed group of “lean” littermates (+/ ob and +/+) of (C57BL/6J ob/ob) often suggest phenotypic characteristics of ob/ob animals. Therefore, it was of interest to determine whether expression of the ob gene had physiological significance in +/ ob animals. Body weight (BW), fasting blood glucose (FBG), and body core temperature (Tr) were monitored between 62 and 364 days of age in +/+ and +/ obmice. Among females but not males, +/ ob mice were heavier ( P = 0.003) and FBG levels were greater ( P = 0.04) than in +/+ animals. Comparison of Trindicated differences suggesting falling Tr in +/ ob but rising Tr in +/+ mice with age in males but not females. Multivariate analysis of variance yielded genotype effects for both males ( P = 0.002) and females ( P = 0.02). BW, FBG, and Tr alone were sufficient at the 75% level for genotypic characterization and separation of +/? animals as +/ ob or +/+; clearly, expression of the ob gene in heterozygotes of the +/ ob animal may make the mixed +/? group inappropriate as lean controls.

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Ethanol-induced hypothermia and hyperglycemia in genetically obese mice

Cited by 5 publications

References 24 publications

Role of α-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity

Role of α-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity

Morphofunctional State and Circadian Rhythms of the Liver under the Influence of Chronic Alcohol Intoxication and Constant Lighting

The obese gene is expressed in lean littermates of the genetically obese mouse (C57BL/6Job/ob)

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