Ethanol elimination rates in men and women in consideration of the calculated liver weight

Dettling, A.; Fischer, Florian; Bohler, S; Ulrichs, F; Skopp, Gisela; Graw, Matthias; Haffner, H. T.

doi:10.1016/j.alcohol.2007.05.003

Cited by 44 publications

(28 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A description of the study population (weight, BMI, maximum BAC, and BrAC measurements) is given in Table 1 as partially presented in previous publications [8,9].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A regression model applied to gender-specific ethanol elimination rates from blood and breath measurements in non-alcoholics

et al. 2008

View full text Add to dashboard Cite

As elimination rates for alcohol are suggested to be gender specific, a novel regression model has been applied to estimate these rates for both men and women using experimentally measured data from 81 female and 96 male volunteers described in previous papers. Breath alcohol measurements were done with the Alcotest 7110 Evidential device and were coupled with concomitant sampling of venous blood. Statistical analyses involved use of a mixed linear model for blood alcohol concentration (BAC) and breath alcohol concentration (BrAC), respectively. The model takes regression lines for each test subject into account with an individual starting value (2 h after the end of drinking) and with an individual alcohol elimination rate per hour (coincidental effects). Further, the data was modeled so that an average alcohol elimination rate per hour could be estimated separately for both genders (constant effects). This enables us to methodically correctly estimate the back calculation. The elimination rates beta (60), which can be used for minimum and maximum back calculations for the BAC, were 0.115 g/kg/h and 0.260 g/kg/h, respectively, for women and 0.096 g/kg/h and 0.241 g/kg/h, respectively, for men. These figures widely deviate from gender-unspecific values commonly used in Germany (0.1 and 0.2 g/kg/h, respectively). The corresponding values for the BrAC were 0.061 mg/l/h and 0.124 mg/l/h for women and 0.049 mg/l/h and 0.112 mg/l/h for men. The probability of an over- or underestimation of the abovementioned extreme values is 0.3% in each case.

show abstract

“…A description of the study population (weight, BMI, maximum BAC, and BrAC measurements) is given in Table 1 as partially presented in previous publications [8,9].…”

Section: Resultsmentioning

confidence: 99%

“…Drinking experiments and methods used for determination of venous blood and breath alcohol concentrations were previously described [8,9] together with the data from 81 female and 96 male volunteers statistically evaluated in the present study.…”

Section: Methodsmentioning

confidence: 99%

A regression model applied to gender-specific ethanol elimination rates from blood and breath measurements in non-alcoholics

et al. 2008

View full text Add to dashboard Cite

show abstract

“…These findings clearly indicate that the same findings were observed in humans and rats after ethanol administration. In addition, Dettling et al 20) reported that when 0.9 g/kg ethanol was administered to humans, the maximum blood alcohol concentration reached 0.841Ϯ0.155 mg/ml. In our present study, it was found that when rats were administered 1 g/kg and 2 g/kg of ethanol to rats, the blood ethanol concentrations were 0.86Ϯ0.12 and 1.09Ϯ0.11 mg/ml, respectively.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ethanol on Sleep-Awake State in Sleep-Disturbed Rats

Obara

Tsutsui

Ishida

et al. 2010

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The present study was undertaken to investigate the effect of ethanol on the sleep-wake cycle in normal rats and sleep-disturbed rats. In normal rats, no significant difference was observed by ethanol in sleep latency, total awake time and total non-rapid eye movement (NREM) sleep time, except for total REM sleep time. On the other hand, in sleep-disturbed rats, ethanol at doses of 1 and 2 g/kg caused significant decreases in sleep latency and total wake time, and an increase in total NREM sleep time. In addition, ethanol showed a significant increase in delta activity in the sleep-disturbed model rat, different from triazolam. These results suggested that ethanol had not only a hypnotic but also a sleep-maintaining effect in sleep-disturbed rats at reasonable blood ethanol concentrations.

show abstract

“…The study was limited to females primarily for pragmatic reasons. First, females outnumbered males, 3:1, in the population from which the sample was drawn, and since the genders have been shown to differ in the rate of alcohol metabolism (Dettlin et al, 2007;Mumenthaler et al, 1999), a large difference in the number of females and males in the study would have been a confound. Second, this research was funded via a time-limited university grant, a fact that would have impeded the successful recruitment and testing of male participants in a number equal to that of females.…”

Section: Participantsmentioning

confidence: 99%

The effects of energy drinks alone and with alcohol on neuropsychological functioning

Curry

Stasio

2009

Human Psychopharmacology

View full text Add to dashboard Cite

show abstract

Ethanol elimination rates in men and women in consideration of the calculated liver weight

Cited by 44 publications

References 47 publications

A regression model applied to gender-specific ethanol elimination rates from blood and breath measurements in non-alcoholics

A regression model applied to gender-specific ethanol elimination rates from blood and breath measurements in non-alcoholics

Effect of Ethanol on Sleep-Awake State in Sleep-Disturbed Rats

The effects of energy drinks alone and with alcohol on neuropsychological functioning

Contact Info

Product

Resources

About