Estudo da preservação do fígado utilizando-se um anti-oxidante: N- Acetilcisteína

Lauz, S; Nigro, Amaury José Teixeira; Taha, Mo; Montero, Edna Frasson de Souza; Junqueira,; Gomes, L; Ramalho, C

doi:10.1590/s0102-86502000000500034

Cited by 3 publications

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“…Na intenção de proteger o fígado das lesões de isquemia e reperfusão, vários tipos de proteção hepática têm sido utilizados, como: a hipotermia 8 , o pré-condicionamento isquêmico 6,9,10,11 e o uso de drogas. 12,13 O termo pré-condicionamento isquêmico significa a indução de um pequeno período de isquemia seguido por pequeno período de reperfusão antes de um período mais longo de isquemia e o seu papel no aumento da tolerância à isquemia tem sido descrito em vários órgãos, inclusive no fígado. 2,6,9,10,14 Lima e col 6 , estudando pré-condicionamento isquêmico no fígado de ratos, relataram que esse método parece atenuar as lesões de isquemiareperfusão provavelmente pelo consumo mais lento do ATP durante a isquemia.…”

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Efeito do óleo de copaíba nas aminotransferases de ratos submetidos à isquemia e reperfusão hepática com e sem pré-condicionamento isquêmico

et al. 2005

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“…Diversas drogas têm sido utilizadas com o intuito de diminuir a lesão causada pela síndrome de isquemia e reperfusão. 12,13 Entretanto, são poucos os relatos científicos sobre os efeitos de plantas medicinais na lesão de isquemia e reperfusão.…”

Section: Introductionunclassified

Efeito do óleo de copaíba nas aminotransferases de ratos submetidos à isquemia e reperfusão hepática com e sem pré-condicionamento isquêmico

et al. 2005

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Immunohistopathological changes in murine Schistosomiasis mansoni under the influence of N-acetyl-L-cysteine

et al. 2012

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The main pathology associated with Schistosomiasis mansoni is granulomatous inflammation that may develop into hepatosplenic disease with fibrosis and hepatoesplenomegaly. It is known that N-acetyl-L-cysteine (NAC) reduces tissue damage in chronic liver diseases owing to its anti-inflammatory, antioxidant, and detoxifying properties. In this study, we investigated the imunohistopathological changes in murine schistosomiasis mansoni under the influence of NAC, in combination with Praziquantel (PZQ) or not. Three groups of mice were formed to evaluate the effects of NAC during infection in the acute, intermediate, and chronic phases. Each group was further subdivided into four subgroups: NAC, PZQ, NAC + PZQ and control (without treatment). Oral administration of NAC (200 mg/kg/day) was carried out on the first day after infection for the acute phase and on the 45th for the intermediate and chronic phases for 59 and 45, 75 days, respectively. PZQ (100 mg/kg/day), was given orally by gavage from the 45th to 49th day after infection. Histopathological analysis of liver tissue provided evidence that combined NAC + PZQ treatment reduced the development of granulomas observed in the chronic phase. Animals treated with NAC and/or PZQ showed a reduction in the size of granulomas and all those treated with NAC exhibited a lower degree of fibrosis. In all groups, NAC decreased the synthesis of interferon-γ and nitric oxide, while increasing the levels of interleukin-10, but it did not influence the production of interleukin-4. On the whole, NAC treatment induced an immunomodulatory effect and reduced liver damage during the granulomatous inflammation in S. mansoni-infected mice.

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Effects of N-Acetylcysteine in hepatic ischemia-reperfusion injury during hemorrhagic shock

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Montero

Figueiredo

et al. 2004

Transplantation Proceedings

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Estudo da preservação do fígado utilizando-se um anti-oxidante: N- Acetilcisteína

Cited by 3 publications

References 0 publications

Efeito do óleo de copaíba nas aminotransferases de ratos submetidos à isquemia e reperfusão hepática com e sem pré-condicionamento isquêmico

Efeito do óleo de copaíba nas aminotransferases de ratos submetidos à isquemia e reperfusão hepática com e sem pré-condicionamento isquêmico

Immunohistopathological changes in murine Schistosomiasis mansoni under the influence of N-acetyl-L-cysteine

Effects of N-Acetylcysteine in hepatic ischemia-reperfusion injury during hemorrhagic shock

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