Effects of N-Acetylcysteine in hepatic ischemia-reperfusion injury during hemorrhagic shock

Portella, A; Montero, Edna Frasson de Souza; Figueiredo, Luiz Francisco Poli de; Bueno, Alberto; Thurow, A.A; Rodrigues, Fernanda Guedes

doi:10.1016/j.transproceed.2004.03.047

Cited by 21 publications

(15 citation statements)

References 16 publications

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“…27,28 NAC also promotes vasodilatation and improves blood flow in microcirculation. 29,30 The lower morphological damage in PTX-treated kidneys suggests a reduction in oxidative stress in this group. PTX, a xanthine derivative, which is a well-known suppressor of TNF-α production from inflammatory cells, has also been shown to inhibit the growth of hepatic stellate cells and inhibit collagen synthesis in these cells.…”

Section: Discussionmentioning

confidence: 91%

Pretreatment with Pentoxifylline andN-Acetylcysteine in Liver Ischemia Reperfusion-Induced Renal Injury

et al. 2012

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Section: Discussionmentioning

confidence: 91%

Pretreatment with Pentoxifylline andN-Acetylcysteine in Liver Ischemia Reperfusion-Induced Renal Injury

et al. 2012

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“…Plasmatic AST activity was evaluated, in 100 l of plasma, using a spectrophotometric assay at ϭ 340 nm (31). After 10-min incubation at room temperature, the absorbance was measured using a U2000 Hitachi spectrophotometer.…”

Section: Methodsmentioning

confidence: 99%

Beneficial effects of rutin andl-arginine coadministration in a rat model of liver ischemia-reperfusion injury

Acquaviva¹,

Lanteri²,

G³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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following liver ischemia results in oxidative stress leading to liver injury. The aim of this study was to investigate the combined effects of two antioxidant agents, rutin and L-arginine, in rat liver ischemia-reperfusion (I/R). Male Wistar rats were divided into five groups: 1) sham operated, 2) I/R, 3) I/R ϩ rutin, 4) I/R ϩ L-arginine, and 5) I/R ϩ rutin ϩ L-arginine. Plasmatic and hepatic levels of alanine transaminase (ALT), aspartate transaminase (AST), lipid peroxides (LOOH), and thiol groups (RSH) were examined, as well as DNA fragmentation and liver histopathology. Furthermore, to elucidate the pathophysiological processes involved in the antioxidant mechanism(s) of rutin and L-arginine, we assessed the expression of inducible (iNOS) and endothelial nitric oxide synthase (eNOS) isoforms and heme oxygenase-1 (HO-1), both playing key roles in the biochemical cascade of liver injury. Significant increase in plasmatic ALT and AST activities were observed in untreated I/R rats compared with sham-operated animals, whereas treatment with rutin or L-arginine in I/R rats reduced hepatic damage. Interestingly, combined therapy with rutin and Larginine resulted in a further reduction of plasmatic ALT and AST activities compared with rutin or L-arginine alone. These results were further confirmed by the analysis of DNA fragmentation, LOOH,

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“…Plasmatic ALT activity was evaluated in 100 ll of plasma, using a spectrophotometric method 15 at k = 340 nm. After 10-min incubation at room temperature, absorbance was measured using a U2000 Hitachi spectrophotometer.…”

Section: Determination Of Alt Activitymentioning

confidence: 99%

Heme oxygenase 1 expression in postischemic reperfusion liver damage: effect of L‐Arginine

et al. 2006

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Ischemia/reperfusion (I/R) injury is a multifactorial process that affects liver function after transplantation and resectional surgery. Alterations in hepatic microcirculation and decreased hepatic flow can cause local hypoxia and consequently liver damage, which is worsened by reperfusion. The aim of this study was to evaluate if treatment with L-arginine improved hepatic function in rats with I/R injury. Animals were treated with L-arginine, ischemized for 30 min, and reperfused for 3 h. Plasmatic levels of GOT, GPT, lipid hydroperoxides (LOOH), and total thiol groups (RSH) were evaluated. In addition, we analyzed hepatic LOOH and RSH levels, DNA fragmentation, heme oxygenase 1 (HO-1) expression, and histological modifications. Our results demonstrate a significant improvement in hepatic function of I/R rats compared to the control group. Treatment with L-arginine increased the expression of HO-1. These data suggest that L-arginine could be useful in preventing oxidative damage during hepatic surgery.

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Effects of N-Acetylcysteine in hepatic ischemia-reperfusion injury during hemorrhagic shock

Cited by 21 publications

References 16 publications

Pretreatment with Pentoxifylline andN-Acetylcysteine in Liver Ischemia Reperfusion-Induced Renal Injury

Pretreatment with Pentoxifylline andN-Acetylcysteine in Liver Ischemia Reperfusion-Induced Renal Injury

Beneficial effects of rutin andl-arginine coadministration in a rat model of liver ischemia-reperfusion injury

Heme oxygenase 1 expression in postischemic reperfusion liver damage: effect of L‐Arginine

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