Beneficial effects of rutin and<scp>l</scp>-arginine coadministration in a rat model of liver ischemia-reperfusion injury

Acquaviva, Rosaria; Lanteri, Raffaele; G, Li Destri; Caltabiano, Rosario; Vanella, Luca; Lanzafame, Salvatore; Cataldo, Antonio Di; Volti, Giovanni Li; Giacomo, Claudia Di

doi:10.1152/ajpgi.90609.2008

Cited by 51 publications

(45 citation statements)

References 44 publications

(51 reference statements)

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“…In this study, a significant protective impact of Larginine supplementation on muscle tissue in experimental ischemia-reperfusion syndrome was demonstrated, in agreement with previous reports by Acquaviva et al [2]. Surprisingly, at the same time we did not observe a direct significant protective effect of L-arginine against I/R injury on rat hepatocytes.…”

Section: Discussionsupporting

confidence: 93%

The influence of short-term l-arginine supplementation on rats’ muscular and hepatic cells in ischemia–reperfusion syndrome

et al. 2011

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Due to the complex mechanisms of L-arginine activity, it is difficult to determine the clinical significance of supplementation with this amino acid. The objective of this study was to determine the influence of short-term supplementation with L-arginine in stress conditions, induced by ischemia-reperfusion syndrome, by assessing the damage to muscular and hepatic cells on the basis of creatine kinase (CK), alanine aminotransferase (ALAT) and aspartic aminotransferase (AspAT) activity in blood and the level of oxygen free radicals in analyzed tissues of rats. We observed that induced ischemia of hind limb caused an increase in CK, ALAT and AspAT activity and an increase in the level of free radicals in liver, but not in skeletal muscle. Supplementation with L-arginine led to a reduction in serum activity of CK and AspAT and reduction of the level of free radicals in analysed tissues. Simultaneous supplementation with L -arginine AND L-NAME resulted in a reversal of changes induced by L-arginine supplementation in the case of AspAT and free radicals in skeletal muscle. The results indicate that under conditions of ischemia-reperfusion, short-term administration of L-arginine has a protective effect on skeletal muscle manifesting itself by reduction of CK in the serum and reduction of free radicals level in THIS tissue.

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Section: Discussionsupporting

confidence: 93%

The influence of short-term l-arginine supplementation on rats’ muscular and hepatic cells in ischemia–reperfusion syndrome

et al. 2011

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“…This finding is in harmony with the study by Acquaviva et al (2009) that found that treatment with rutin in rats subjected to I/R injury produced a significant reduction of plasma ALT, AST activities and lipid peroxides level. Rutin is an efficient antioxidant, free radical scavenger and has been shown to quench the hydroxyl radical, superoxide anion radical, and peroxynitrite anion (Patil et al, 2013).…”

Section: Discussionsupporting

confidence: 90%

The protective effect of Catechin and Rutin on cigarette smoke extract-induced injury in irradiated rats

et al. 2017

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T HE present study was designed to investigate the possible protective effects of catechin and rutin and their possible mechanisms of action in guarding against the oxidative stress and inflammation induced by ionizing radiation and/ or cigarette smoke extract in rats. Exposure of rats to acute doses of γ-radiation or administration of cigarette smoke extract (CSE) in this study were found to exert an oxidative stress due to generation of ROS, which are characterized by elevation in MDA and nitric oxide levels and depletion in reduced glutathione, as well as elevation in MPO activity and level of TNF-α. The results also showed that activities of ALT, AST, ALP, and LDH were increased. Damaging effects were significantly increased in animals exposed to gamma radiation combined with administration of cigarette smoke extract in comparison to either irradiation or administration of cigarette smoke extract. Pretreatment with catechin or rutin largely protected against the change in all the measured parameters. Conclusion: Catechin and rutin might have the potential to modulate the damage induced by radiation exposure in cigarette smoke-treated animals

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“…Interestingly, the induction of HO-1 was found in quercetin-treated but not in rutin-treated rat glioma C6 cells [44] and in the hydrogen peroxide-induced apoptosis of RAW264.7 macrophages [45] . However, rutin acted as a strong HO-1 inducer in a rat model of liver ischemia-reperfusion injury [46] , suggesting a cell typedependent activation of this enzyme. Additionally, the nuclear translocation of HO-1 could be involved in the regulation of genes responsible for cytoprotection against oxidative stress [47] .…”

Section: Discussionmentioning

confidence: 94%

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

et al. 2012

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Aim: To investigate the mechanisms underlying the protective effects of quercetin-rutinoside (rutin) and its aglycone quercetin against CCl 4 -induced liver damage in mice. Methods: BALB/cN mice were intraperitoneally administered rutin (10, 50, and 150 mg/kg) or quercetin (50 mg/kg) once daily for 5 consecutive days, followed by the intraperitoneal injection of CCl 4 in olive oil (2 mL/kg, 10% v/v). The animals were sacrificed 24 h later. Blood was collected for measuring the activities of ALT and AST, and the liver was excised for assessing Cu/Zn superoxide dismutase (SOD) activity, GSH and protein concentrations and also for immunoblotting. Portions of the livers were used for histology and immunohistochemistry. Results: Pretreatment with rutin and, to a lesser extent, with quercetin significantly reduced the activity of plasma transaminases and improved the histological signs of acute liver damage in CCl 4 -intoxicated mice. Quercetin prevented the decrease in Cu/Zn SOD activity in CCl 4 -intoxicated mice more potently than rutin. However, it was less effective in the suppression of nitrotyrosine formation. Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl 4 -induced activation of nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α) and cyclooxygenase (COX-2). The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin. Treatment with both flavonoids significantly increased NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO-1) expression in injured livers, although quercetin was less effective than rutin at an equivalent dose. Quercetin more potently suppressed the expression of transforming growth factor-β1 (TGF-β1) than rutin. Conclusion: Rutin exerts stronger protection against nitrosative stress and hepatocellular damage but has weaker antioxidant and antiinflammatory activities and antifibrotic potential than quercetin, which may be attributed to the presence of a rutinoside moiety in position 3 of the C ring.

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Beneficial effects of rutin andl-arginine coadministration in a rat model of liver ischemia-reperfusion injury

Cited by 51 publications

References 44 publications

The influence of short-term l-arginine supplementation on rats’ muscular and hepatic cells in ischemia–reperfusion syndrome

The influence of short-term l-arginine supplementation on rats’ muscular and hepatic cells in ischemia–reperfusion syndrome

The protective effect of Catechin and Rutin on cigarette smoke extract-induced injury in irradiated rats

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

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