Estudio de la vulnerabilidad a reentradas a través de modelos matemáticos y simulación de la aurícula humana

Villa, Raúl; Alberto, Carlos

doi:10.4995/thesis/10251/9104

Cited by 3 publications

(2 citation statements)

References 203 publications

(379 reference statements)

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“…This model has been the basis of more recently developed models. [147][148][149] In 2010 Ruiz-Villa 147 and Tobón 150 developed, in this research group, an anatomically realistic 3D atrial model based on the atrial surfaces of the Harrild and Henriquez model. This new model improved the anatomy and the electrophysiology proposed by Harrild and Henriquez and was one of the first models in including realistic fiber orientation.…”

Section: D Atrial Modelsmentioning

confidence: 99%

Mapping of the electrical activity of human atria. Multiscale modelling and simulations

Martinez-Mateu¹

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Atrial fibrillation is one of the most common cardiac arrhythmias seen in clinical practice. Therefore, it is of vital importance to develop new technologies aimed at diagnosing and terminating this kind of arrhythmia, to improve the quality of life of patients and to reduce costs to national health systems. In the last years, new atrial mapping techniques based on multi-electrode systems are increasingly being used to map the atrial electrical activity in humans and localise and target atrial fibrillation drivers in the form of focal sources or rotors. However, significant concerns remain about their accuracy and experimental approaches to analyse them are limited due to their invasive character. Therefore, computer simulations are a helpful tool to overcome these limitations since they can reproduce with fidelity experimental observations, permit to split the problem to treat into more simple substudies, and allow the possibility of performing preliminary investigations impossible to carry out in the clinical practice. This PhD thesis is focused on the analysis for accuracy of the multielectrode mapping systems through computational models and simulations. For this purpose, we developed realistic multiscale models in order to simulate atrial electrical reentrant activity, first in a sheet of atrial tissue and, then, in the whole atria. Then, we analysed the effects of the multi-electrode geometrical configurations on the accuracy of localizing rotors, by using multi-electrode arrays with equidistant inter-electrode distances, as well as multi-electrode basket catheters with non-equidistant inter-electrode distances. After computing the intracavitary unipolar electrograms, we performed phase maps, phase singularity detections to track rotors, and dominant frequency maps. We finally found out that the accuracy of multi-electrode mapping systems depends on their position inside the atrial cavity, the electrodeto-tissue distance, the inter-electrode distance, and the contribution of far field sources. Furthermore, as a consequence of these factors, false rotors might appear and could contribute to failure of atrial fibrillation ablation procedures. xii RESUM llunyà. A més, com a conseqüència d'aquests factors, es va observar l'aparició de rotors falsos que podrien contribuir al fracàs de l'ablació de la fibril•lació auricular.

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Section: D Atrial Modelsmentioning

confidence: 99%

Mapping of the electrical activity of human atria. Multiscale modelling and simulations

Martinez-Mateu¹

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“…The dimensions of these regions and anatomical structures have been previously collected in two thesis carried out within our research group (Ruiz-Villa 2010;Tobón 2010) and Table 2.1 shows the most relevant sizes.…”

Section: Atrial Anatomymentioning

confidence: 99%

Three-dimensional Multiscale Modelling and Simulation of Atria and Torso Electrophysiology

Albero¹

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Propagación de onda en un tejido cardiaco 3D usando dos modelos auriculares

Castaño

Ruíz

Castillo

et al. 2013

Revista Colombiana de Cardiología

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Estudio de la vulnerabilidad a reentradas a través de modelos matemáticos y simulación de la aurícula humana

Cited by 3 publications

References 203 publications

Mapping of the electrical activity of human atria. Multiscale modelling and simulations

Mapping of the electrical activity of human atria. Multiscale modelling and simulations

Three-dimensional Multiscale Modelling and Simulation of Atria and Torso Electrophysiology

Propagación de onda en un tejido cardiaco 3D usando dos modelos auriculares

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