Estrogen receptors in human breast cancer tissue

Maaß, H.; Engel, B.; Hohmeister, H.; Lehmann, F.; Trams, G.

doi:10.1016/0002-9378(72)90688-6

Cited by 98 publications

(23 citation statements)

References 7 publications

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“…54 No consistent relationship between plasma estradiol and the ER content of breast carcinomas has been reported. [62][63][64][65] There is a blood-tissue gradient of estradiol that varies considerably between individuals, and, in general, plasma estradiol levels do not reflect tissue estradiol levels. 66,67 In postmenopausal women, the levels of estradiol in breast tissue are much greater than plasma levels.…”

Section: Hormone Receptors and Breast Cancer Proliferationmentioning

confidence: 99%

Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre‐ and postmenopausal women

Talley

Grizzle

Waterbor

et al. 2001

Intl Journal of Cancer

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Breast cancers in younger, premenopausal women are more likely to exhibit an adverse prognostic profile (including negative steroid hormone receptors and a high rate of cellular proliferation) and poor outcome than breast cancers in postmenopausal women. It has been hypothesized that this adverse prognostic profile is a result of the higher histologic grade of breast cancers in pre-compared with post-menopausal women. To assess the association of expression of steroid hormone receptors and indicators of proliferation while controlling for histologic grade, we identified 100 infiltrating ductal carcinomas from premenopausal women 45 years of age or younger and 100 from postmenopausal women 65 years of age or older. The carcinomas were selected so that the histologic grades (low versus high) were distributed equally between the 2 groups. Estrogen receptors (ER), progesterone receptors (PR), p27 Kip1 and Ki-67 (to measure rate of proliferation) were assessed by immunohistochemistry and compared between groups. Clinical information and survival data were also analyzed. ER content was lower and proliferation was higher in carcinomas in premenopausal women (p ‫؍‬ 0.048 and p ‫؍‬ 0.005, respectively). By univariate analysis, p27 Kip1 and PR were not different between the groups; however, in multivariate analysis, p27 Kip1 was higher in postmenopausal women, but only in a subgroup with highly proliferative carcinomas. Overall survival was similar in the pre-and postmenopausal women. Furthermore, low p27 Kip1 and African-American ethnicity predicted a poorer overall survival in the premenopausal, but not in the postmenopausal, women in our study. After controlling for histologic grade, a lower expression of ER and a higher proliferative index were detected in breast carcinomas in premenopausal women. Therefore, some prognostic indicators, such as ER and proliferative rate, may be more closely associated with menopausal status than histologic grade. Our data also suggest that some prognostic factors are not equally effective as predictors of survival in pre-and postmenopausal women. Prognosis in women with breast cancer has been reported to differ according to age and menopausal status. Studies examining this issue have varied in design, age categorization and outcome measures. A few large population-based studies and more limited analyses 1-5 have indicated that women under the ages of 30 -40 years have a worse prognosis. Some retrospective studies have attempted to explain the less favorable outcome in younger women and have reported that breast cancers in younger women exhibit more adverse characteristics, including a high clinical stage at diagnosis, high histologic grade, lack of steroid hormone receptors and increased proliferation. 6 -9 Multivariate analyses to assess associations of age and menopausal status with other clinical and pathologic characteristics have not consistently retained either variable as an independent adverse prognosticator, 8 although several multivariate analyses have indicated that young ag...

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Section: Hormone Receptors and Breast Cancer Proliferationmentioning

confidence: 99%

Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre‐ and postmenopausal women

Talley

Grizzle

Waterbor

et al. 2001

Intl Journal of Cancer

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“…Various conditions for incubation with oestrogens or charcoal have been proposed (1)(2)(3)(4)(5)(6)(7)(8)(9)(16)(17)(18)(19) varying from 30 minutes to several hours at temperatures from 4 °C to 30 °C. However, most relevant reports present no data on the time course.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of and Additional Data on an Improved Simple Charcoal Method to Determine Oestrogen Receptors

Korsten¹,

Persijn²

1977

Clinical Chemistry and Laboratory Medicine

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Summary: Additional information and some modifications of an earlier published method ((1972) Z. Klin. Chem. Klin. Biochem., 10, 502-508) for the assay of oestrogen receptor in human breast tumours are presented. The correlation between the results obtained with this method and with the electrophoresis procedure of Wagner ((1972) Hoppe Seyler's Z. Physiol. Chem., 353', 1235-1245) was found to be good. The use of glycerol stabilized calf uterus extract for quality control is proposed. Various factors affecting the assay and the discrimination between receptor positive and receptor negative are critically discussed.

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“…Oestrogen receptor concentration is influenced by menstrual status, tumour cellularity and tumour grade (Steele et al, 1982), and also rises with increasing age (e.g., Clark & McGuire, 1983;Mercer et al, 1983;Daxenbichler et al, 1982). The influence of tissue and plasma levels of oestrogen on ER concentration, however, is as yet less clearly understood: whilst high levels of circulating oestrogen have been found to be associated with low/absent tumour ER in premenopausal women (Maass et al, 1972;Nagai et al, 1979;Hawkins et al, 1979), less is known about this relationship in postmenopausal women.…”

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confidence: 99%