Estrogen-receptor protein in intracranial meningiomas

Donnell, Mark S.; Meyer, Glenn A.; Donegan, William L.

doi:10.3171/jns.1979.50.4.0499

Cited by 208 publications

(66 citation statements)

References 20 publications

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“…In our study of 116 meningiomas, none of them display ER immunoreactivity. On the other hand, we find that the majority of meningiomas is immunoreactive for PR, in agreement with other authors [5][6][7][8]16,17 . The presence of PR and lack of ER has led to believe that these PRs are estrogen independent, unlike PRs present in other hormoneregulated tumors, such as breast and uterus.…”

Section: Discussionsupporting

confidence: 82%

“…Also, it has been observed that these tumors often grow during pregnancy and luteal phase of the menstrual cycle 2 and there is an association between meningiomas and breast cancer and other tumors wich have hormonal dependency 3,4 . Based in these data, there have been many reports which have dealt with the presence of estrogen receptor (ER) and progesterone receptors (PR) in meningiomas [5][6][7][8][9][10][11][12][13][14][15] . In recent years, the development of monoclonal antibodies specific for steroid hormone receptors has permitted the detection of PR and ER direct in tissue.…”

mentioning

confidence: 99%

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Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors

Hilbig

Barbosa-Coutinho

1998

Arq. Neuro-Psiquiatr.

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-The authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic and they used an immunohistochemical technique for estrogen and progesterone receptors attempting to determine if there is any difference between typical and non-typical tumors in relation to hormone receptors. The immunohistochemical technique to estrogen receptors was negative in all meningiomas studied. Progesterone receptors were detected in 58.3% of typical, and in 48.2% of non-typical meningiomas. This difference was not statistically significant. However, individually considering the criteria used for selection of non-typical tumours, those that concurrently displayed brain invasion and increased mitotic activity or necrosis, as well as the summation of those three features, were predominantly negative for progesterone receptors (respectively p=0.038; p=0.001; and p=0.044). The authors conclude that estrogen receptors were not present in meningiomas; that progesterone receptors in isolation are not enough to predict a higher tumoral malignancy but can be useful associated with other histological features.KEY WORDS: meningioma, progesterone receptor, estrogen receptor, immunohistochemistry. Meningiomas e receptores hormonais: estudo imuno-histoquímico em tumores típicos e não típicosRESUMO -Os autores avaliam 116 meningiomas classificados em típicos, atípicos ou anaplásicos usando técnica imuno-histoquímica para receptores de estrógeno (ER) e progesterona (PR) com o objetivo de determinar se existe diferença entre tumores típicos e não típicos em relação aos receptores hormonais. Todos os tumores estudados foram negativos para ER. Os receptores de progesterona foram detectados em 58,3% dos meningiomas típicos e em 48,2% dos tumores não-típicos. Essa diferença não foi estatisticamente significativa. Entretanto, considerando os critérios utilizados para seleção dos não-típicos, os tumores que apresentavam, de forma concomitante, invasão do sistema nervoso central e aumento da taxa mitótica ou necrose, bem como a soma das três características, foram predominantemente negativos para PR (p=0,038; 0,01 e 0,044, respectivamente). Os autores concluem que: ERs não estão presentes em meningiomas; PRs estão presentes na maioria dos meningiomas; a negatividade para PR isoladamente não é suficiente para predizer maior malignidade mas pode ser útil se associada a outras características histológicas. PALAVRAS-CHAVE: meningioma, receptores de progesterona, receptores de estrógeno, imunohistoquímica.Meningiomas are the most common meningeal tumors of the central nervous system. These tumors arise from the arachnoidial layer of meninges and, although they are generally benign, there are many cases showing atypical and anaplastic features 1 . Epidemiological data suggest that female sex hormones may play a role in the growth of meningiomas. They show a higher incidence in

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Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 99%

Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors

Hilbig

Barbosa-Coutinho

1998

Arq. Neuro-Psiquiatr.

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“…It has been suggested that the higher estrogen and progesterone levels in the female might influence the growth of meningiomas. 20,21 The intracranial distribution of the meningiomas in our series agrees with that noted in other large series. 5,[14][15][16][17][18][19] Meningiomas of the base were more predominant in females than were those in the vault.…”

Section: Discussionsupporting

confidence: 82%

Intracranial Meningiomas: Analysis of 53 Consecutive Cases with Special Reference to their Operability and Surgical Outcome

et al. 1990

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Fifty-three cases of intracranial meningiomas were retrospectively analyzed with regard to the age and sex distribution, anatomic location, mode of presentation, surgical management, and outcome. Patient age ranged from 25 to 80 years (average, 47.7 years); overall male to female ratio was 1:1.9. Tumor locations were: 26.4% sphenoidal ridge, 20.8% convexity, 17% sagittal or parasagittal, 13.2% olfactory groove, 11.3% suprasellar, 9.4% infratentorial, and 1.9% multiple. Delayed diagnosis and referral were common and accounted for a higher number of patients with severe neurologic deficit and blindness. Forty-two patients underwent 47 surgical procedures for tumor removal; 38 were first operations and 9 were for recurrences. Tumor removal was total in 61% of the first and 33% of the repeat operations; the highest rates were achieved for lesions in the convexity (100%) and the lowest for basal (29%) meningiomas. Outcome following first surgery was excellent in 37%, good to satisfactory in 39%, and poor in 8% of the cases. There was a total of 6 (16%) postoperative deaths; however, the 30-day postoperative mortality was 5.3%. The recurrence rate was 5.6% after total and 30% after partial resection. Our results emphasize the importance of early diagnosis and treatment of intracranial meningiomas.

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“…Following the first report in 1979, on the putative presence of oestrogen receptors (ER) in human meningiomas (Donnell et al, 1979), several research groups, including our own (Blankenstein et al, 1983;Martuza et al, 1985) have tried to confirm these findings. Using Scatchard plot analysis (Blaauw et al, 1986) or enzyme immunoassay (Blankenstein et al, 1987) the majority of meningiomas were found to be ER negative.…”

mentioning

confidence: 83%

Detection of an oestrogen receptor-like protein in human meningiomas by band shift assay using a synthetic oestrogen responsive element (ERE)

Koehorst

Jacobs²,

Thijssen³

et al. 1993

Br J Cancer

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When a ligand binding or enzyme immunoassay is used, meningiomas are found to be rich in progestin receptors (PR) whereas oestrogen receptors (ER) are virtually undetectable. A protein that can bind to an oestrogen responsive element (ERE) was detected in meningiomas, by using the band-shift assay. The binding of ER to the ERE is inhibited by the anti-ER monoclonal antibody ER-P31, which is directed to the A/B domain of the ER, indicating that the binding protein is an ER-like protein. Images Figure 1 p291-b Figure 2 Figure 3

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Estrogen-receptor protein in intracranial meningiomas

Cited by 208 publications

References 20 publications

Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors

Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors

Intracranial Meningiomas: Analysis of 53 Consecutive Cases with Special Reference to their Operability and Surgical Outcome

Detection of an oestrogen receptor-like protein in human meningiomas by band shift assay using a synthetic oestrogen responsive element (ERE)

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