Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors

Abstract

-The authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic and they used an immunohistochemical technique for estrogen and progesterone receptors attempting to determine if there is any difference between typical and non-typical tumors in relation to hormone receptors. The immunohistochemical technique to estrogen receptors was negative in all meningiomas studied. Progesterone receptors were detected in 58.3% of typical, and in 48.2% of non-typical meningiomas. This difference was not statistically significant. However, individually considering the criteria used for selection of non-typical tumours, those that concurrently displayed brain invasion and increased mitotic activity or necrosis, as well as the summation of those three features, were predominantly negative for progesterone receptors (respectively p=0.038; p=0.001; and p=0.044). The authors conclude that estrogen receptors were not present in meningiomas; that progesterone receptors in isolation are not enough to predict a higher tumoral malignancy but can be useful associated with other histological features.KEY WORDS: meningioma, progesterone receptor, estrogen receptor, immunohistochemistry. Meningiomas e receptores hormonais: estudo imuno-histoquímico em tumores típicos e não típicosRESUMO -Os autores avaliam 116 meningiomas classificados em típicos, atípicos ou anaplásicos usando técnica imuno-histoquímica para receptores de estrógeno (ER) e progesterona (PR) com o objetivo de determinar se existe diferença entre tumores típicos e não típicos em relação aos receptores hormonais. Todos os tumores estudados foram negativos para ER. Os receptores de progesterona foram detectados em 58,3% dos meningiomas típicos e em 48,2% dos tumores não-típicos. Essa diferença não foi estatisticamente significativa. Entretanto, considerando os critérios utilizados para seleção dos não-típicos, os tumores que apresentavam, de forma concomitante, invasão do sistema nervoso central e aumento da taxa mitótica ou necrose, bem como a soma das três características, foram predominantemente negativos para PR (p=0,038; 0,01 e 0,044, respectivamente). Os autores concluem que: ERs não estão presentes em meningiomas; PRs estão presentes na maioria dos meningiomas; a negatividade para PR isoladamente não é suficiente para predizer maior malignidade mas pode ser útil se associada a outras características histológicas. PALAVRAS-CHAVE: meningioma, receptores de progesterona, receptores de estrógeno, imunohistoquímica.Meningiomas are the most common meningeal tumors of the central nervous system. These tumors arise from the arachnoidial layer of meninges and, although they are generally benign, there are many cases showing atypical and anaplastic features 1 . Epidemiological data suggest that female sex hormones may play a role in the growth of meningiomas. They show a higher incidence in

Immunohistochemical expression of aromatase and estrogen, androgen and progesterone receptors in normal and neoplastic human meningeal cells

“…In the meningiomas under study, the frequency of PR immunopositivity (60.3%) was consistent with previous reports of rates ranging between 60% and 100% 16,34,35 . The ER immunoexpression (24.6%) found in the present study was in agreement with the literature that reports positivities between 0–68%, 35–38 whereas AR expression (18.3%) was lower than that found in two other published studies, which showed frequency rates of 39% and 51% 39,40 .…”

Rhabdoid Meningioma: Clinical Features and MR Imaging Findings in 15 Patients

“…16 Actually, progesterone receptor positivity has been reported to negatively correlate with tumor grade by many authors. [16][17][18][19] In other words, there is a reduction of progesterone receptors from WHO grade I to grade II and a progesterone receptor negativity in WHO grade III tumors. [16][17][18][19] The reason why RM presents similarly to benign meningioma is not clear.…”

“…[16][17][18][19] In other words, there is a reduction of progesterone receptors from WHO grade I to grade II and a progesterone receptor negativity in WHO grade III tumors. [16][17][18][19] The reason why RM presents similarly to benign meningioma is not clear. However, this may be because of the fact that the rhabdoid morphology can only present in a part of the tumor, though most RMs have high A B C Fig 1. A 64-year-old woman presenting with memory disturbances.…”

The Impact of Gonadal Hormones on the Expression of Human Neurological Disorders

“…There is also clinical and radiological evidence for the rapid growth of meningiomas during pregnancy, followed by their spontaneous regression postpartum [109]. Progesterone receptor-negative meningiomas tend to display greater mitotic indices and necrosis [110], a higher propensity for brain invasiveness and shorter disease-free intervals [111]. The antiprogestin agent RU486 has been reported to stabilize growth or induce regression of meningiomas.…”