Rhabdoid Meningioma: Clinical Features and MR Imaging Findings in 15 Patients

Kim, E.Y.; Weon, Young Cheol; Kim, S.T.; Kim, H.-J.; Byun, Hong Sik; Lee, J.-I.; Kim, J.H.

doi:10.3174/ajnr.a0601

Cited by 41 publications

(28 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diagnosis of RM was strictly based on previously published criteria [1][2][3]. At diagnosis, the 59-year-old male patient had a mass in the floor of the right middle cranial fossa.…”

Section: Patient and Samplementioning

confidence: 99%

See 1 more Smart Citation

Identification of CD105 (endoglin)-positive stem-like cells in rhabdoid meningioma

Wang

Mao

et al. 2011

J Neurooncol

View full text Add to dashboard Cite

To investigate the tumor-initiating cells (TICs) in rhabdoid meningioma (RM), a population of CD105-positive cells isolated from a fresh RM surgical sample was analyzed for proliferative activity, self-renewal ability, tumorigenic ability, multilineage differentiation potential, as well as chromosomal aberrations. The results showed that isolated CD105-positive cells could be maintained for more than 50 generations in vitro. These cells exhibited increased proliferative activity and single-cell tumor sphere-formation ability compared with CD105-negative cells. In vivo experiments showed that CD105-positive cells possessed much greater potential to reconstitute the original human RM in nude mice as compared with CD105-negative cells. Phenotypically, CD105-positive cells shared some surface markers with mesenchymal progenitor cells (MPCs), but karyotype analysis showed chromosomal abnormalities characteristic of malignant meningioma, thus distinguishing them from supportive stroma-derived MPCs. In addition, in contrast to CD105-negative cells, CD105-positive cells could differentiate into adipocytes and osteocytes in response to specific induction agents. Finally, CD105-positive cells with stem-like features were also isolated from xenograft tumors. In conclusion, a population of CD105-positive TICs with some traits of MPCs was identified in RM and might provide a promising therapeutic target in management of malignant meningioma.

show abstract

“…The diagnosis of RM was strictly based on previously published criteria [1][2][3]. At diagnosis, the 59-year-old male patient had a mass in the floor of the right middle cranial fossa.…”

Section: Patient and Samplementioning

confidence: 99%

“…Despite radical surgical excision and adjuvant radio-and chemotherapy, RM usually exhibits early recurrence, metastasis, and poor prognosis. Previous reports have mainly focused on clinical and histological features of RM, but rarely on its oncogenesis, particularly the tumor-initiating cells (TICs) [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Identification of CD105 (endoglin)-positive stem-like cells in rhabdoid meningioma

Wang

Mao

et al. 2011

J Neurooncol

View full text Add to dashboard Cite

show abstract

“…To the best of our knowledge, 50 cases of RM, including three case series, have been published in the English-language literature. 2,3,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Rhabdoid features usually emerge as a focal change, in either benign or malignant meningiomas of other histological subtypes. 2,3 Pure variants of such tumors are very uncommon, but rhabdoid components tend to be more prominent in recurrent tumors.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic analysis of rhabdoid meningioma

Lin

Wang

et al. 2010

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

“…Generally, the prognosis is poor, and many case reports are available on pediatric patients in the literature. On CT and MRI, the tumor demonstrates severe peritumoral edema in 75 %, cyst formation in 38 %, and mixed bone destruction and hyperostosis in 33 % of the cases [27].…”

Section: Other Histological Variantsmentioning

confidence: 99%