Detection of an oestrogen receptor-like protein in human meningiomas by band shift assay using a synthetic oestrogen responsive element (ERE)

Koehorst, S. G. A.; Jacobs, Heinz; Thijssen, J. H. H.; Blankenstein, M.A.

doi:10.1038/bjc.1993.330

Cited by 19 publications

(3 citation statements)

References 17 publications

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“…The morbidity and mortality of benign forms of meningiomas can be influenced by other factors, mostly the tumour location and the radicality of resection, age and comorbidities [ 8 , 15 , 16 ]. Some authors have proven specific female-associated factors that increase the incidence of meningiomas in female population, which we confirmed also in our cohort [ 17 , 18 ]. Also, several genetic changes could play an important role in meningioma pathogenesis [ 19 ].…”

Section: Discussionsupporting

confidence: 91%

Neurosurgical treatment and outcome patterns in patients with meningioma in South Moravian region—a population-based study

Duba,

Mrlian,

Rošková

et al. 2023

Neurol Sci

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Introduction Meningiomas are usually slow-growing tumours, constituting about one third of all primary intracranial tumours. They occur more frequently in women. Clinical manifestation of meningiomas depends on their location, tumour size and growth rate. In most cases, surgical treatment is the procedure of choice. The success of this treatment is, however, associated with the radicality of the resection. Radiotherapy represents an additional or alternative treatment modality. Gamma knife surgery is another notable treatment method, especially in small and/or slow-growing tumours in eloquent areas or in elderly patients. Material and methods Authors describe their experience with the diagnosis, treatment and outcome of the patients with meningioma (n = 857). Furthermore, they also assess the postoperative morbidity/mortality and recurrence rate. Results and conclusions In view of the benign histology of meningiomas, the success of the treatment largely depends (besides the tumour grading) on the radicality of the resection. The emphasis is also put on appropriate follow-up of the patients. In certain patients, the watch and wait strategy should be also considered as a suitable treatment method.

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Section: Discussionsupporting

confidence: 91%

Neurosurgical treatment and outcome patterns in patients with meningioma in South Moravian region—a population-based study

Duba,

Mrlian,

Rošková

et al. 2023

Neurol Sci

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“…22 Another indirect argument for a biological role of variant ER transcripts is the correlation between their demonstration in tissues that are ER negative by binding assay and the presence of products of estrogen-responsive genes such as progesterone receptors 16,23 or pS2. 24 The presence of proteins capable of binding specifically to estrogen-responsive elements was shown by gel-mobility shift assay in certain ER-negative breast cancers 25 and in meningiomas 26 ; in the latter, the protein, different from the wild type ER, was recognized by antibodies specific for a region different from the hormone-binding domain of the receptor. A surprising correspondence with the events we have shown in humans has been shown in rats treated with peroxisome proliferators 27 : in this experimental model, which closely resembles human carcinogenesis, there FIG.…”

Section: Discussionmentioning

confidence: 99%

Variant liver estrogen receptor transcripts already occur at an early stage of chronic liver disease

et al. 1998

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Variant estrogen receptors may be found in hepatocellular carcinoma and may influence its natural history. Because it is not known whether their occurrence is an early or a late event during the course of chronic liver disease or whether they cluster in some subgroups of patients, we investigated a series of patients in different stages of chronic liver disease. One hundred eleven consecutive patients were studied for variant estrogen receptor transcripts by reversetranscription polymerase chain reaction of RNA extracted from liver biopsy specimens. In chronic active hepatitis, variant estrogen receptor transcripts were coexpressed with wild-type significantly more often in men than in women (P ‫؍‬ .029) and in hepatitis B surface antigen (HBsAg)-positive subjects than in subjects positive for antibody to hepatitis C virus (P ‫؍‬ .0006). In hepatocellular carcinoma, again in men (P ‫؍‬ .004) and in HBsAg-positive patients (P ‫؍‬ .0015), the variant estrogen receptor transcript was overexpressed or remained the only one expressed. Patients with liver cell dysplasia presented with the same estrogen receptor pattern than patients with hepatocellular carcinoma. This further reinforces the significance of liver cell dysplasia as a preneoplastic condition. The significantly higher occurrence of variant estrogen receptor in men (especially in HBsAg-positive men) already at an early stage of disease, like chronic active hepatitis, suggests that the alteration of estrogen receptors, favoring uncontrolled proliferation and development of hyperplasia, might constitute a prominent mechanism facilitating neoplastic transformation especially in men. (HEPATOLOGY 1998;27:983-988.)

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“…13 Progesterone receptors (PR) are expressed in 40-100% of meningiomas, are localized to the nuclei and are transcriptionally active. 13 Progesterone receptors (PR) are expressed in 40-100% of meningiomas, are localized to the nuclei and are transcriptionally active.…”

Section: Molecular Biologymentioning

confidence: 99%

Atypical and Malignant Meningiomas

Alexiou¹,

Kaba

Kyritsis³

2012

Textbook of Uncommon Cancer

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Detection of an oestrogen receptor-like protein in human meningiomas by band shift assay using a synthetic oestrogen responsive element (ERE)

Cited by 19 publications

References 17 publications

Neurosurgical treatment and outcome patterns in patients with meningioma in South Moravian region—a population-based study

Neurosurgical treatment and outcome patterns in patients with meningioma in South Moravian region—a population-based study

Variant liver estrogen receptor transcripts already occur at an early stage of chronic liver disease

Atypical and Malignant Meningiomas

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