Estrogen receptor gene is associated with dental fluorosis in Brazilian children

Dalledone, Mariana; Cunha, Arthur S; Ramazzotto, Lucas Alexandre; Pecharki, Giovana Daniela; Filho, Paulo Nelson; Scariot, Rafaela; Trevilatto, Paula Cristina; Vieira, Alexandre R.; Küchler, Érika Calvano; Brancher, João Armando

doi:10.1007/s00784-018-2778-2

Cited by 17 publications

(13 citation statements)

References 33 publications

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“…Additionally, the importance of ERs on cortical and trabecular bone, and also in different bone cell types have been widely explored (42). Although the studied genetic polymorphism rs2234693 and rs9340799 in ESR1 and rs1256049 and rs4986938 were not associated with PAP in the present study, they were previously associated with many different bone conditions (28,43) and oral conditions (43)(44)(45). The genetic polymorphisms rs2234693 and rs9340799 in ESR1 have been largely studied.…”

Section: Discussionmentioning

confidence: 62%

Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

et al. 2020

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This study evaluated the association between polymorphisms in genes encoding estrogen receptors 1 (ESR1) and 2 (ESR2), vitamin D receptor (VDR) and in microRNA17 (which binds to ESR1 and VDR) with persistent apical periodontitis (PAP) after the endodontic treatment. We included 162 patients who completed endodontic treatment at least one year ago and presented apical periodontitis at the beginning of the root canal therapy. Clinical and radiographic exams were performed to evaluate the presence of PAP or healthy periradicular tissues (healed). Saliva samples were collected as a genomic DNA. The genotyping of ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938), VDR (rs739837 and rs2228570) and miRNA17 (rs4284505) were performed by real-time PCR. Chi-square test was used to the distribution of genotype and allele frequencies. Haplotype analysis was also performed. Eighty-nine patients were included in the “healed” group and 73 in the “PAP” group. No association was found between the allelic and genotypic polymorphisms studied and PAP (p>0.05). Haplotype analysis also did not demonstrated an association (p>0.05). In conclusion, the genetic polymorphisms in ESR1, ESR2, VDR and miRNA17 are not associated with PAP.

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Section: Discussionmentioning

confidence: 62%

Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

et al. 2020

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“…For this cross-sectional study, children aged between 10 and 14 years old (mean ± SD ¼ 12.0 ± 0.47) were recruited at public and private schools of Curitiba, Paran a, Brazil, a city with fluoridation of public water supplies. The publication of the government control of the public water measurements reported that in Curitiba the fluoride level ranged from 0.72 to 0.77 parts per million of fluoride (ppm F), in accordance with Paran a State regulation for water fluoridation and the prevalence of DF in this population was previously reported as 27.3% [11]. Children were not included if, using orthodontic appliances, syndromic or presented any other enamel alteration.…”

Section: Studied Populationmentioning

confidence: 80%

“…In the present study, we decide to evaluate a miR-SNP, which may play functional roles through affecting the transcription of the target gene, altering pri-miRNA/pre-miRNA processing, or exerting effects on miRNA-mRNA interactions [26]. The target gene selected here was ESR1, which was previously associated with DF in a Chinese population [5] and in our population [11], both populations have a high prevalence of DF. Curitiba, the studied city here, was one of the first Brazilian cities to promote the fluoridation of water supply [27].…”

Section: Discussionmentioning

confidence: 99%

“…Based on the previous studies associating ESR1 with DF [5,11], a search was performed in order to identify miRNAs that potentially bind to the mRNA of the ESR1. The search and selection of the miRNA was performed through the miRanda software [17], which was used to scan miRNAs-ESR1 mRNA interactions.…”

Section: Mir-snp Selection and Laboratory Analysismentioning

confidence: 99%

“…Despite, the pathogenesis of DF is intimately linked to the exposure to fluoride, which is considered the main environmental factor. Some studies have shown that a significant association between DF susceptibility and various single nucleotide polymorphisms (SNP) exist in genes expressed during enamel development [4][5][6][7][8][9][10], including the SNPs rs1256049, rs2234693 [5] and rs12154178 [11] in Oestrogen Receptor Alpha (ERa). ERa is codified by Oestrogen Receptor-1 (ESR1) gene, which is located on the sixth (6q25) chromosome [12].…”

Section: Introductionmentioning

confidence: 99%

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Single nucleotide polymorphism rs4284505 in microRNA17 and risk of dental fluorosis

Abbasoğlu

Dalledone

Wambier

et al. 2020

Acta Odontologica Scandinavica

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Objectives: The aim of this study is to evaluate the association between the single nucleotide polymorphism (SNP) rs4284505 within the gene that codifies microRNA17 (miRNA17) and dental fluorosis (DF) in a group of children. Methods: Children living in a city with fluoridation of public water supplies were included. DF was assessed in erupted permanent teeth by Dean's modified index. The miR-SNP rs4284505 was selected in miRNA17 and genotyping was carried out by real-time PCR. Genotype and allelic distributions between DF and control, and between DF phenotypes (mild, moderate and severe) and control were analysed. Results: Among a total of 527 children enrolled for the study, 383 were DF free and 144 presented DF. In the dominant model analysis (AA þ AG vs. GG) the miR-SNP rs4284505 was associated with moderate DF, with carriers of the GG genotype having an increased risk of more than two times for DF (p ¼ 0.031; Odds Ratio ¼ 2.26, Confidence Interval 95%¼ 1.04-4.73). Allelic distribution showed borderline statistical significance for moderate DF with the carriers of G allele having an increased risk for DF (p ¼ .050; Odds Ratio ¼ 1.75, Confidence Interval 95%¼ 1.00-3.12). Conclusion: The miR-SNP rs4284505 in miRNA17 was associated with an increased risk of DF.

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Possible Association Between Polymorphisms in ESR1, COL1A2, BGLAP, SPARC, VDR, and MMP2 Genes and Dental Fluorosis in a Population from an Endemic Region of West Bengal

Chakraborty

Pramanik

Datta

et al. 2022

Biol Trace Elem Res

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Estrogen receptor gene is associated with dental fluorosis in Brazilian children

Cited by 17 publications

References 33 publications

Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

Single nucleotide polymorphism rs4284505 in microRNA17 and risk of dental fluorosis

Possible Association Between Polymorphisms in ESR1, COL1A2, BGLAP, SPARC, VDR, and MMP2 Genes and Dental Fluorosis in a Population from an Endemic Region of West Bengal

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