Possible Association Between Polymorphisms in ESR1, COL1A2, BGLAP, SPARC, VDR, and MMP2 Genes and Dental Fluorosis in a Population from an Endemic Region of West Bengal

Chakraborty, Arijit; Pramanik, Sreemanta; Datta, Kallol; Goswami, Rakesh; Saha, Depanwita; Majumdar, Kunal Kanti; Sikdar, Nilabja

doi:10.1007/s12011-021-03072-8

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…In addition, Rahila et al (2019) reported that this polymorphism was associated with the severity of the disease. On the other hand, Jarquín-Yáñez et al (2018) observed that the C allele of rs412777 increased the risk of the more severe levels of DF, unlike Escobar-García et al (2016), Saha et al (2021), and Chakraborty et al (2022), who did not indicate associations with the same SNP [ 18 , 23 , 26 , 29 , 33 , 35 ].…”

Section: Discussionmentioning

confidence: 97%

“…In contrast, Wang et al (2010) and Dalledone et al (2019) agreed on the absence of association. Ending with estrogen receptors, Dalledone et al (2019) studied six polymorphisms of the Estrogen-Related Receptor Beta (ESRβ) without observing associations with DF [ 20 , 21 , 27 , 33 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…D4: Bias in measurement of the outcome. D5: Bias in the selection of the report result [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Figurementioning

confidence: 99%

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Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review

González-Casamada

Nevárez-Rascón

et al. 2022

Dentistry Journal

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Genetic factors contribute to susceptibility and resistance to fluoride exposure. The aim of this systematic review was to identify alleles/genotypes of single nucleotide polymorphisms (SNPs) associated with dental fluorosis (DF) and to identify them as protective or risk factors. PubMed, ScienceDirect, Cochrane Library, Scopus and Web of Science were searched for articles; the last search was performed in August 2022. Human studies that analyzed the relationship between SNPs and DF published in English were included; systematic reviews and meta-analyses were excluded. Methodological quality was graded using the Joanna Briggs Institute checklist and risk of bias was assessed using the Cochrane Collaboration’s tool. Eighteen articles were included, 44% of which showed high methodological quality and data from 5,625 participants aged 6 to 75 years were analyzed. The SNPs COL1A2, ESR2, DLX1, DLX2, AMBN, TUFT1, TFIP11, miRNA17, and SOD2 were considered risk factors, and ESR1, MMP20, and ENAM were considered protective factors. In conclusion, there are alleles and genotypes of different single nucleotide polymorphisms involved in increasing or decreasing the risk of developing dental fluorosis.

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