1965
DOI: 10.1002/jcp.1030660410
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Estrogen control of the synthesis of RNA and protein in the uterus

Abstract: Estrogen action in the rat uterus can be arbitrarily considered as occurring in three steps. The first step is the interaction of the estrogen with the target tissue. This appears to be of stereospecific interaction with a receptor that is sensitive to proteinases and extremes of pH and insensitive to ribonuclease and deoxyribonuclease. The second step involves a change in the biological activity of this receptor protein due to the interaction with estrogen, a mechanism about which we have no definitive inform… Show more

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Cited by 110 publications
(21 citation statements)
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“…The analysis of this newly synthesized RNA revealed the increased synthesis of DNA-like RNA, ribosomal RNA, and transfer RNA . This mode of increase has been observed in other hormone dependent organs such as seminal vesicles, Greenman et al, 1965) and uterus (Gorski et al, 1965). According to Drews and Brawerman (1967), the same results were observed in cortisol-stimulated liver nuclei.…”
Section: Synopsissupporting
confidence: 74%
“…The analysis of this newly synthesized RNA revealed the increased synthesis of DNA-like RNA, ribosomal RNA, and transfer RNA . This mode of increase has been observed in other hormone dependent organs such as seminal vesicles, Greenman et al, 1965) and uterus (Gorski et al, 1965). According to Drews and Brawerman (1967), the same results were observed in cortisol-stimulated liver nuclei.…”
Section: Synopsissupporting
confidence: 74%
“…The administration of inhibitors of protein synthesis, such as puromycin or cycloheximide, just before or even immediately after oestradiol injection suppresses the increased RNA synthesis by low salt RNA polymerase activity [12] . It thus appears that one of the earliest effects of oestradiol is to induce a "first-stage" protein synthesis, sufficiently slight to pass easily undetected by conventional techniques during the "lag period" of the first hour, but of crucial importance *Postal address: Lab Hormones, F 94 BicBtre, France.…”
Section: Introductionmentioning
confidence: 99%
“…Steroids could act either on nuclear transcription of the genetic message, at cytoplasmic sites to regulate translational expression of existing message into protein end products, or both. Present model systems such as the estrogen stimulation of the immature rat uterus (6), the androgen growthpromoting activity for male accessory sex glands (7), and glucocorticoid effects on rat liver (8,9) have firmly established the role of steroids in initiating and controlling protein synthesis. However, the actual step in protein synthesis that is, primarily influenced is unclear because of the "mass" stimulation of synthesis of many proteins,.…”
Section: Introductionmentioning
confidence: 99%