1972
DOI: 10.1016/0014-5793(72)80228-x
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Inhibition by α‐amanitin of the oestradiol‐induced increase in α‐amanitin insensitive RNA polymerase in immature rat uterus

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Cited by 30 publications
(4 citation statements)
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References 17 publications
(9 reference statements)
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“…This early stimulation of putative mRNA synthesis (Knowler and Smellie, 1971;Glasser et al, 1972;Borthwick and Smellie, 1975) may be involved in the subsequent synthesis of uterine proteins involved in the later increase of both polymerases and, in turn, other proliferative changes which characterize the uterotrophic action of estrogen. A similar suggestion was made by Raynaud-Jammet et al (1972) who found an RNA product whose synthesis, which was sensitive to aamanitin, appeared necessary for the increase in RNA polymerase I activity which followed estradiol administration. Our present results would indicate, however, that the action of estrogen on RNA synthesis may be more complex and difficult to interpret than simply relating an early effect in RNA polymerase II activity to the synthesis of a product that modulates the later increases in the activities of the polymerases.…”
Section: Discussionsupporting
confidence: 73%
“…This early stimulation of putative mRNA synthesis (Knowler and Smellie, 1971;Glasser et al, 1972;Borthwick and Smellie, 1975) may be involved in the subsequent synthesis of uterine proteins involved in the later increase of both polymerases and, in turn, other proliferative changes which characterize the uterotrophic action of estrogen. A similar suggestion was made by Raynaud-Jammet et al (1972) who found an RNA product whose synthesis, which was sensitive to aamanitin, appeared necessary for the increase in RNA polymerase I activity which followed estradiol administration. Our present results would indicate, however, that the action of estrogen on RNA synthesis may be more complex and difficult to interpret than simply relating an early effect in RNA polymerase II activity to the synthesis of a product that modulates the later increases in the activities of the polymerases.…”
Section: Discussionsupporting
confidence: 73%
“…Evidence is now accumulating that growth-stimulating hormones do produce increased activity of the nucleolar polymerase I in the responsive tissue (Smuckler & Tata, 1971;Yu & Feigelson, 1971;Sadjel & Jacob, 1971;Mainwaring et al, 1971). These observations are consistent with the demonstration that the nucleolar polymerase is a metabolically labile species that is turned over with considerable rapidity (Yu & Feigelson, 1972;Raynaud-Jammet et al, 1972), making it ideally suited for such a regulatory role. Generalizing from our own findings and those of others (Smuckler & Tata, 1971;Chesterton et al, 1972), the amount of the nucleoplasmic enzyme may be more constant in a given cell with control of nucleoplasmic RNA synthesis being exerted at other levels of organization.…”
Section: Discussionsupporting
confidence: 88%
“…More recent studies on the RNA polymerases of eukaryotic cells have revealed the presence of at least two classes of enzyme, RNA polymerase A and RNA polymerase B (Chambon et al, 1970;Roeder & Rutter, 1970;Chesterton & Butterworth, 1971;Chesterton et al, 1972). Previous measurements of the RNA polymerase activities of nuclei from the uteri of immature or ovariectomized rats have shown that oestradiol causes an increase in the endogenous RNA polymerase A activity 1-2h after hormone treatment although no changes were detected in the activity of RNA polymerase B during the first 12h (Barry & Gorski, 1971;Raynaud-Jammet et al, 1972).…”
Section: Vol 147mentioning
confidence: 99%