Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin

Hall, Glenda K.; Phillips, Tania J.

doi:10.1016/j.jaad.2004.08.039

Cited by 266 publications

(216 citation statements)

References 98 publications

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“…It is previously implicated that estrogen plays an important role in the pathogenesis of pigmentation and skin aging (Krause, 2006;Hall and Phillips, 2005;Verdier-Sevrain et al, 2006), and our data seems to support this viewpoint.…”

Section: Discussionsupporting

confidence: 86%

Survey on skin aging status and related influential factors in Southeast China

Wang

Fang

Zhu

2009

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To investigate cutaneous aging patterns of residents in Hangzhou, Zhejiang, China, and their contributing factors. Methods: Eight hundred and forty-eight Hangzhou residents received the survey between March 2004 and September 2004. Results: Facial wrinkling first occurred at 21 years of age and skin elasticity began to lose at 22 years of age. In middle-aged and old people, facial wrinkling and looseness escalated with the increase of ultraviolet (UV)-exposure time, indicating the accelerating effect of a higher accumulative dose of UV radiation on skin aging. Only Fitzpatrick types II, III and IV were found in the skin phototypes of residents in Hangzhou area, and Fitzpatrick type II seemed to be much more subject to severe wrinkling, elasticity destruction and skin tumors than types III and IV. The oily skin was more protected against wrinkling and facial looseness than dry skin. However, as to concomitant cutaneous diseases, no difference was found among different skin types. Conclusion: Age, solar-exposure time, Fitzpatrick type and skin type are the associated forces in promoting skin aging, and emotional factor seems to be another independent risk factor. The age of 49 years and 2 h/d of solar-exposure time seem to be the turning points responsible for dramatic changes of cutaneous appearance in the process of skin aging in Southeast China.

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Section: Discussionsupporting

confidence: 86%

Survey on skin aging status and related influential factors in Southeast China

Wang

Fang

Zhu

2009

J. Zhejiang Univ. Sci. B

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“…Reduced estrogen levels in post-menopausal women contributes to wrinkling, dryness, atrophy, laxity, poor wound healing, and vulvar atrophy, 111 and loss of collagen appears to bemore closely related to postmenopausal age than chronologic age. 112, 113 Estrogen therapy (HRT) may prevent collagen loss and can stimulate synthesis of collagen in those that have lower initial collagen levels.…”

Section: Womenmentioning

confidence: 99%

Introduction to skin aging

Tobin

2017

Journal of Tissue Viability

400

332

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“…21 We investigated whether and how this contributes to delayed repair in estrogen-treated mice. Chronic estrogen treatment did not greatly influence epidermal thickness in the MF1 mice used in this study (Table 4).…”

Section: Skin Architecture In Estrogen-treated Micementioning

confidence: 99%

17β-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α

Gilliver

Emmerson

Campbell

et al. 2010

The American Journal of Pathology

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Although estrogens have long been known to accelerate healing in females, their roles in males remain to be established. To address this, we have investigated the influence of 17␤-estradiol on acute wound repair in castrated male mice. We report that sustained exposure to estrogen markedly delays wound re-epithelialization. Our use of hairless mice revealed this response to be largely independent of hair follicle cycling, whereas other studies demonstrated that estrogen minimally influences wound inflammation in males. Additionally , we report reduced collagen accumulation and increased gelatinase activities in the wounds of estrogen-treated mice. Increased wound matrix metalloproteinase (MMP)-2 activity in these animals may i) contribute to their inability to heal skin wounds optimally and ii) stem , at least in part , from effects on the overall levels and spatial distribution of membrane-type 1-MMP and tissue inhibitor of MMP (TIMP)-3 , which respectively facilitate and prevent MMP-2 activation. Using mice rendered null for either the ␣ or ␤ isoform of the estrogen receptor , we identified estrogen receptor-␣ as the likely effector of estrogen's inhibitory effects on healing.

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Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin

Cited by 266 publications

References 98 publications

Survey on skin aging status and related influential factors in Southeast China

Survey on skin aging status and related influential factors in Southeast China

Introduction to skin aging

17β-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α

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