Estrogen and Progesterone Binding Proteins in Normal Human Myometrium and Leiomyoma Tissue

Pollow, K.; Geilfuss, J; Boquoi, E; Pollow, Barbara

doi:10.1515/cclm.1978.16.9.503

Cited by 31 publications

(20 citation statements)

References 27 publications

(24 reference statements)

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“…A possible explana tion was suggested by Pollow et al [6] who found that the activity of (3-hydroxysteroid dehydrogenase, which converts 17 p-estradiol to estrone, a much less potent estrogen, is lower in myomas than in surrounding muscle. These authors also found a higher estradiol-binding capacity and a lower concentration of progesterone receptors in myoma, as compared to normal myometrium [7], These findings could well explain increased estrogen effect on myomas even when the prevailing hormonal environment is low in estrogens.…”

Section: Discussionmentioning

confidence: 75%

Glycogen Metabolism of Normal Human Myometrium and Leiomyoma – Possible Hormonal Control

Milwidsky¹,

Gutman²

1983

Gynecol Obstet Invest

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Glycogen concentration and the activities of enzymes of glycogen metabolism in myometrium of pre- and postmenopausal and pregnant women and in myomas were determined. Glycogen concentration in muscle from nonpregnant women was about 3 mg/g and rose to 13 mg/g in tissues obtained during cesarean sections. The activities of glycogen synthase phosphatase and phosphorylase were also markedly higher in myometrium of pregnant women. In 5 out of 8 myomas glycogen concentration and enzyme activities were similar to those found at the end of pregnancy. These observations suggest that glycogen metabolism of the myometrium is under the control of hormones and that the local hormonal environment of myomas may be different from that of the surrounding tissue.

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Section: Discussionmentioning

confidence: 75%

Glycogen Metabolism of Normal Human Myometrium and Leiomyoma – Possible Hormonal Control

Milwidsky¹,

Gutman²

1983

Gynecol Obstet Invest

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“…it was inferred that the receptors were biochemically similar in both tissues. Work by Pollow et al 17 on sedimentation patterns as well as elution profiles in agarose , showing that the properties of the receptors in leiomyoma and myometrium are similar. supports this conclusion.…”

Section: Discussionmentioning

confidence: 99%

Oestrogen and Progesterone Receptor Concentrations in Leiomyoma and Normal Myometrium

et al. 1987

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SUMMARY. The content of cytoplasmic 17~oestradiol and progesterone receptors in human uterine leiomyoma and normal myometrium in the Negroid population was determined. Eighteen women of reproductive age. at various stages of the menstrual cycle. were included in the study. The serum oestrogen and progesterone concentrations were also measured. This is the first report in the literature in which oestrogen and progesterone receptors in leiomyoma are significantly higher than in normal myometrium (P=().()002). The steroid dependence of the growth of leiomyomas may be related to the steroid receptor level. The presence of persistently high concentrations of oestrogen and progesterone receptors in leiomyoma should be helpful in the treatment of this benign tumour.Leiomyoma of the uterus is the most common solid pelvic benign tumour in the female and occurs in nearly 20'Yo of all women during reproductive life.' The tumour increases in size during pregnancy or in response to exogenous oestro~en and regresses following menopause. -I For unknown reasons the incidence is much higher in the Negroid population than in Caucasians. I. 5. h Sufficient data are not available at present to suggest any conclusion regarding the aetiology of uterine leiomyomas. Nevertheless. it seems that leiomyomas arise from a single neoplastic parent cell derived from the smooth muscle elements of the myometrium and the growth of cells is influenced by various factors in the cellular environment. including the effect of steroid borrnones.""The concentration of oestrogen and progesterone receptors in human uterine leiomyoma and normal myometrium were measured in an attempt to clarify the relation of receptors to tumour growth in the Negroid population. We have also studied the concentrations of serum 17~oestradiol and progesterone with respect to steroid receptor concentrations in leiomyoma and normal myometrium at different phases of the menstrual cycle. Materials and methods PATIENTSEighteen women were included in the study. Each of these women had a hysterectomy for leiomyoma at Baragwanath Hospital. Criteria for patient selection included reproductive age, history of regular menstrual cycles and no history of exogenous hormone usage.The menstrual cycle dating was done by last menstrual period. by histologic evaluation of the endometrial specimen and serum progesterone levels. On the day of the operation a venous blood sample was obtained, allowed to clot and centrifuged. Serum was separated and frozen at -20°C. REAGENTSThe radioligands (2. 4, 6, 7 3H(N)) 17~oestra-diol, specific activity 95 Ci/rnmol. and 171~ methyl-3(lI)prornogesterone .263

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“…In the majority of the studies reviewed, the concentrations of both the ERs and PRs were greater in leiomyomata than the myometrium Brandon et al 1993Brandon et al , 1995Buchi and Keller 1983;Eiletz et al 1980;Englund et al 1998;Kawaguchi et al 1991;Lessl et al 1997;Marugo et al 1989;Nisolle et al 1999;Otsuka et al 1989;Pollow et al 1978a;Puukka et al 1976;Rein et al 1990c;Sadan et al 1987;Soules and McCarty 1982;Tamaya et al 1979Tamaya et al , 1985Vij et al 1990;Viville et al 1997;Vollenhoven et al 1994;Wilson et al 1980). In addition, Sadan et al found the ER and PR to be elevated in fibroids during all phases of the menstrual cycle when compared with matched myometria (Sadan et al 1987).…”

Section: Laboratory Studiesmentioning

confidence: 98%

Etiology and pathogenesis of uterine leiomyomas: a review.

Flake

Andersen

Dixon

2003

Environ Health Perspect

494

392

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Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become symptomatic in one-third of these women. They are the most frequent indication for hysterectomy in the United States. Although the initiator or initiators of fibroids are unknown, several predisposing factors have been identified, including age (late reproductive years), African-American ethnicity, nulliparity, and obesity. Nonrandom cytogenetic abnormalities have been found in about 40% of tumors examined. Estrogen and progesterone are recognized as promoters of tumor growth, and the potential role of environmental estrogens has only recently been explored. Growth factors with mitogenic activity, such as transforming growth factor-β 3, basic fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion. These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review.

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Estrogen and Progesterone Binding Proteins in Normal Human Myometrium and Leiomyoma Tissue

Cited by 31 publications

References 27 publications

Glycogen Metabolism of Normal Human Myometrium and Leiomyoma – Possible Hormonal Control

Glycogen Metabolism of Normal Human Myometrium and Leiomyoma – Possible Hormonal Control

Oestrogen and Progesterone Receptor Concentrations in Leiomyoma and Normal Myometrium

Etiology and pathogenesis of uterine leiomyomas: a review.

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