SUMMARY. The content of cytoplasmic 17~oestradiol and progesterone receptors in human uterine leiomyoma and normal myometrium in the Negroid population was determined. Eighteen women of reproductive age. at various stages of the menstrual cycle. were included in the study. The serum oestrogen and progesterone concentrations were also measured. This is the first report in the literature in which oestrogen and progesterone receptors in leiomyoma are significantly higher than in normal myometrium (P=().()002). The steroid dependence of the growth of leiomyomas may be related to the steroid receptor level. The presence of persistently high concentrations of oestrogen and progesterone receptors in leiomyoma should be helpful in the treatment of this benign tumour.Leiomyoma of the uterus is the most common solid pelvic benign tumour in the female and occurs in nearly 20'Yo of all women during reproductive life.' The tumour increases in size during pregnancy or in response to exogenous oestro~en and regresses following menopause. -I For unknown reasons the incidence is much higher in the Negroid population than in Caucasians. I. 5. h Sufficient data are not available at present to suggest any conclusion regarding the aetiology of uterine leiomyomas. Nevertheless. it seems that leiomyomas arise from a single neoplastic parent cell derived from the smooth muscle elements of the myometrium and the growth of cells is influenced by various factors in the cellular environment. including the effect of steroid borrnones.""The concentration of oestrogen and progesterone receptors in human uterine leiomyoma and normal myometrium were measured in an attempt to clarify the relation of receptors to tumour growth in the Negroid population. We have also studied the concentrations of serum 17~oestradiol and progesterone with respect to steroid receptor concentrations in leiomyoma and normal myometrium at different phases of the menstrual cycle. Materials and methods PATIENTSEighteen women were included in the study. Each of these women had a hysterectomy for leiomyoma at Baragwanath Hospital. Criteria for patient selection included reproductive age, history of regular menstrual cycles and no history of exogenous hormone usage.The menstrual cycle dating was done by last menstrual period. by histologic evaluation of the endometrial specimen and serum progesterone levels. On the day of the operation a venous blood sample was obtained, allowed to clot and centrifuged. Serum was separated and frozen at -20°C. REAGENTSThe radioligands (2. 4, 6, 7 3H(N)) 17~oestra-diol, specific activity 95 Ci/rnmol. and 171~ methyl-3(lI)prornogesterone .263

The objective of the study was to investigate if a single dose of Hexoprenaline administered to patients diagnosed as having fetal distress improves neonatal outcome and whether there are any side effects and complications related to hexoprenaline injection. Patients with fetal distress diagnosed by electronic fetal heart rate monitoring with a gestational age of 35 weeks or more in active labor were eligible. Once the decision to deliver the patient by Cesarean section was made, patients were approached and randomised by sealed opaque envelopes to hexoprenaline or control groups. Ten micrograms of hexoprenaline were administered intravenously to study patients. Main outcomes were cord blood gas values, Apgar scores, the need for resuscitation and admission to intensive care. There were no statistically significant differences in the main outcome measures between the two groups. Fewer babies in the hexoprenaline group had a pH of < 7.2 and a base excess of < -10, but this was not statistically significant. The fetal heart rate pattern was improved in significantly more patients after hexoprenaline administration than controls. In conclusion, despite the statistically significant improvement in fetal heart rate tracings, Apgar scores and blood gas values showed only a trend towards improvement in the hexoprenaline group.

Background: In the presence of both HIV infection and cervical intraepithelial neoplasia (CIN), the risk of cancer development despite treatment may be greater. We investigated clinical predictors of persistent cytological abnormalities in women who had had a large loop excision of the transformation zone (LLETZ).

There was no difference in the up- or downgrading of cervical dysplasia between the 2 referral groups.