Estrogen and/or Calcium Plus Vitamin D Increase Mandibular Bone Mass

Hildebolt, Charles F.; Pilgram, Thomas K.; Dotson, Mary; Armamento-Villareal, Reina; Hauser, J.; Cohen, S.; Civitelli, Roberto

doi:10.1902/jop.2004.75.6.811

Cited by 40 publications

(32 citation statements)

References 28 publications

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“…Although the beneficial effects of calcium and vitamin D supplementation on bone health have been well recognized, 27–29 their potential role in periodontal disease has not been fully determined. A number of studies 30–37 suggested that vitamin D and/or calcium intake results in reduced alveolar bone loss, gingival inflammation, and/or attachment loss. Most relevant are data on subjects (∼12,000) enrolled in the Third National Health and Nutrition Examination Survey (NHANES III), suggesting that lower dietary intake of calcium increased attachment loss in a dose‐dependent fashion 38 .…”

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confidence: 99%

Cross‐Sectional Study of Vitamin D and Calcium Supplementation Effects on Chronic Periodontitis

Miley

Garcia

Hildebolt

et al. 2009

Journal of Periodontology

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136

115

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Background Low dietary intakes of vitamin D and calcium hasten bone loss and osteoporosis. Because vitamin D metabolites may also alter the inflammatory response and have anti-microbial effects, we studied whether use of vitamin D and calcium supplements affects periodontal disease status. Methods A cohort of 51 subjects receiving periodontal maintenance therapy was recruited from 2 dental clinics. Of these, 23 were taking vitamin D (≥400 international units/day) and calcium (≥1000mg/day) supplementation, and 28 were not taking such supplementation. All subjects had ≥2 interproximal sites with ≥3 mm clinical attachment loss. Daily calcium and vitamin D intakes (from food and supplements) were estimated by nutritional analysis. The following clinical parameters of periodontal disease were recorded for the mandibular posterior teeth: gingival index, probing depth, cementoenamel junction-gingival margin distance (attachment loss), bleeding upon probing, and furcation involvement. Posterior photostimulable-phosphor bitewing radiographs were taken to determine cementoenamel-junction-alveolar-crest distances (alveolar crest height loss). Data were analyzed with a repeated-measures, multivariate analysis of variance. Results Relative to subjects who did not take vitamin D and calcium supplementation, supplement takers had shallower probing depths, fewer bleeding sites, lower gingival index values, fewer furcation involvements, less attachment loss and less alveolar crest height loss. The repeated-measures analysis indicated that collectively these differences for clinical parameters were borderline significant (P=0.08). Conclusion In these subjects receiving periodontal maintenance therapy, there was a trend for better periodontal health with intake of vitamin D and calcium supplementation. More expanded longitudinal studies are required to determine the potential of this relationship.

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mentioning

confidence: 99%

Cross‐Sectional Study of Vitamin D and Calcium Supplementation Effects on Chronic Periodontitis

Miley

Garcia

Hildebolt

et al. 2009

Journal of Periodontology

Self Cite

136

115

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“…30) Although the effect of a calcium supplement on reducing bone loss was less than that of an estrogen treatment, 31) clinical studies have indicated that it was more effective than 1-hydroxyvitamin D 3 in preventing loss of BMD among elderly women over a four-year period. 32) Current research has revealed that hormone replacement therapy (HRT), accompanied by a calcium supplement 33) and monofluorophosphates or 1-hydroxyvitamin D 3 , can help increase BMD among postmenopausal women. 34) A supplement of calcium or of calcium and vitamin D is generally prescribed to osteoporotic patients undergoing treatment with alendronate, 35) clodronate, 36) ipriflavone, [37][38][39] calcitriol 40) and disodium palmidronate.…”

Section: Discussionmentioning

confidence: 99%

Calcium from LactoCalcium^TMMilk Mineral after Digestion with Pepsin Stimulates Mineralized Bone Nodule Formation in Human Osteoblast-Like SaOS-2 Cellsin Vitroand May Be Rendered Bioavailablein Vivo

Rao¹,

Khan²,

Gluck³

2007

Bioscience, Biotechnology, and Biochemistry

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“…Estudos mostraram que a DOM está fortemente correlacionada com o número de dentes remanescentes em mulheres na pós-menopausa e sugerem que a perda óssea sistêmica contribui para a perda dos dentes [16][17][18][19] . Porém, um estudo seccional não encontrou diferença significativa quando utilizados os parâmetros clínicos periodontais em 292 mulheres osteopênicas 20 no qual foram encontrados média de dentes presentes de 17,2±7 e PIC no valor de 2,8±0,9 mm.…”

Section: Densitometria óSsea Mineralunclassified

“…No entanto, analisando os grupos de mulheres estrógeno suficientes e deficientes, os parâmetros periodontais não mostraram tal associação, como apresentado em estudos semelhantes 13,16,21 . Estes estudos concluíram que a osteopenia na pós-menopausa constitui fator de risco para a doença periodontal.…”

Section: Densitometria óSsea Mineralunclassified

Menopausa: fator de risco para doença periodontal?

Pallos

Ceschin²,

Victor

et al. 2006

Rev. Bras. Ginecol. Obstet.

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Objetivo: verificar se existe relação entre os parâmetros periodontais e os níveis de estrógeno e densitometria óssea mineral (DOM). Métodos: foram avaliadas 46 mulheres na pós-menopausa entre 44 e 68 anos de idade (52,2±4,8) e 15 mulheres como grupo controle entre 35 e 54 anos de idade (44,7±7,5). Parâmetros periodontais como profundidade à sondagem (PS), perda de inserção clínica (PIC) e dentes ausentes (DA) foram comparados com os níveis de estrógeno (suficiente e deficiente) e DOM em normais, osteopênicas e osteoporóticas. Os dados foram comparados pela diferença das médias entre os grupos e analisados pelo teste de Aspin-Welch. Resultados: as médias dos parâmetros de PS, PIC e DA, quando associados ao grau da DOM em normais (2,1±0,5; 2,9±1,4 e 10,6±5,0), osteopênicas (2,3±0,7; 3,0±1,1 e 12,8±5,1) e osteoporóticas (2,4±0,6; 2,7±0,9 e 14,3±5,7), não mostraram diferenças significativas (p>0,05). Foi encontrada diferença significante entre o grupo controle e nas mulheres menopausadas para PIC e DA. Quando comparados com os níveis de estrógeno os resultados demonstraram igualdade para os parâmetros periodontais. Conclusões: apesar de alguns estudos demonstrarem correlação positiva da doença periodontal com osteoporose e com os níveis de estrogênio, na população de mulheres menopausadas estes dados não foram confirmados neste estudo. PALAVRAS-CHAVE:Periodontite; Menopausa; Densitometria; Estrógeno ABSTRACT Purpose: to verify if there is a relationship between the clinical periodontal parameters and estrogen levels and bone mineral density (BMD). Methods: forty-six post-menopausal women aged 44 to 68 years (52.2±4.8) and 15 women aged 35 to 54 years (44.7±7.5) were evaluated. Periodontal parameters like probing depth (PD), clinical attachment loss (CAL), and missing teeth (MT) were compared with estrogen levels (sufficient and insufficient) and BMD (normal, osteopenic and osteoporotic). Data of the mean difference between the groups were compared by the Aspin-Welch test. Results: the means of PD, CAL and MT, when associated with the normal (2.1±0.5; 2.9±1.4 and 10.6±5.0), osteopenic (2.3±0.7; 3.0±1.1 and 12.8±5.1) and osteoporotic BMD (2.4±0.6; 2.7±0.9 and 14.3±5.7), did not show statistical difference (p>0.05). A significant difference was found between the control group and postmenopausal women for CAL and MT. When compared with the estrogen levels the results did not show a difference regarding the periodontal parameters. Conclusion: although some studies showed a positive correlation with osteoporosis and estrogen level, in this population of menopausal women these findings were not confirmed.

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Estrogen and/or Calcium Plus Vitamin D Increase Mandibular Bone Mass

Cited by 40 publications

References 28 publications

Cross‐Sectional Study of Vitamin D and Calcium Supplementation Effects on Chronic Periodontitis

Cross‐Sectional Study of Vitamin D and Calcium Supplementation Effects on Chronic Periodontitis

Calcium from LactoCalcium^TMMilk Mineral after Digestion with Pepsin Stimulates Mineralized Bone Nodule Formation in Human Osteoblast-Like SaOS-2 Cellsin Vitroand May Be Rendered Bioavailablein Vivo

Menopausa: fator de risco para doença periodontal?

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Estrogen and/or Calcium Plus Vitamin D Increase Mandibular Bone Mass

Cited by 40 publications

References 28 publications

Cross‐Sectional Study of Vitamin D and Calcium Supplementation Effects on Chronic Periodontitis

Cross‐Sectional Study of Vitamin D and Calcium Supplementation Effects on Chronic Periodontitis

Calcium from LactoCalciumTMMilk Mineral after Digestion with Pepsin Stimulates Mineralized Bone Nodule Formation in Human Osteoblast-Like SaOS-2 Cellsin Vitroand May Be Rendered Bioavailablein Vivo

Menopausa: fator de risco para doença periodontal?

Contact Info

Product

Resources

About

Calcium from LactoCalcium^TMMilk Mineral after Digestion with Pepsin Stimulates Mineralized Bone Nodule Formation in Human Osteoblast-Like SaOS-2 Cellsin Vitroand May Be Rendered Bioavailablein Vivo