Estimation of the prevalence and distribution of HPV genotypes and identification of related risk factors among Turkish women

Abstract

Aim of the studyThe present study aims to estimate the prevalence and distribution of HPV genotypes and identify related risk factors among Turkish women.Material and methods11 624 Turkish women attending our gynaecological clinic and expressing a desire for access to cervical cancer screening were assessed during the years 2014–2016. Cervical specimens were collected and transported using the HC2 HPV DNA Collection Device (consisting of a cervical brush and digene Specimen Transport Medium).ResultsAmong these 11 624 individuals, positive HPV test results were obtained for 325 (2.79%), and negative results were observed for 11 299 (97.2%). The vast majority of patients were between the 3rd and 5th decades and the mean age of the patients was 44 ±9.12 (range 27–66). Among the HPV-positive women, 205 were positive for a single HPV type (205/325 = 63.1% of HPV infections; 205/11624 = 1.76% of all samples) and 120 were positive for multiple types (120/325 = 36.9% of HPV infections; 120/11624 = 1.03% of all samples). The four most prevalent high-risk types were HPV 16, 31, 51 and 52, with frequencies of 11.25%, 7.83%, 6.06% and 3.16%, respectively.ConclusionsThere appears to be geographic variation in the distribution of HPV genotypes. In this study, the four most prevalent high-risk types were HPV 16, 31, 51 and 52, with frequencies of 11.25%, 7.83%, 6.06% and 3.16%, respectively.

Human Papilloma Virus Genotype Distribution in Women with Cervical Intraepithelial Neoplasia

“…21 Kulhan et al recently reported that among the 325 HPV-positive women screened, 63.1% were positive for a single HPV type while the remaining 36.9% were positive for multiple and the four most prevalent high-risk types were HPV 16, 31, 51 and 52. 16 In the presented patient group 21.6% of the 189 patients had more than one HPV genotype positivity. A study from USA reported an incidence of 4.6% for ≥ 2 HPV genotype among 74 543 women screened and the authors pointed out the possible importance of interaction between the HPV genotypes.…”

“…A recent study from Turkey reported similar values as a mean age of the patient group with HPV 16 or 31 positivity was reported to be 42.83 ±8.6, while the mean age of the remaining group with other HPV genotypes was 44.71±9.34. 16 In a study from Turkey, Yuce et al screened 890 women and reported that a prevalence of any HPV as 25.7% while high-risk HPV positivity was A study from Denmark reported the prevalence of high-risk HPV positivity as 20.6% among 40 382 women who were screened-with the highest incidence encountered in women of 20-23 years old (46.0%)-while HPV 16 was found to be the most prevalent genotype. CIN III was more frequent when the HPV genotype was present alongside with HPV 16 rather than being a single HPV infection or when it is linked to other high-risk HPV genotypes.…”

“…The histopathological results of the colposcopy-guided biopsies were evaluated according to the presence of oncogenic HPV types (HPV 16 . Twenty-five percent of the patients (n=48) were smokers.…”

The prevalence of hrHPV among the isolated community in the Highland of Bario, Sarawak, East Malaysia

“…If we would have speci ed the age range of the participants according to the national guideline, the hrHPV prevalence would be much lower at 2.67% (2/75) from the age range between 40-59. To date, the lowest published hrHPV prevalence rate is among the Turkish women (2.79%; n=11624) (29). The very low hrHPV prevalence may be contributed by the socio-cultural characteristics and widespread monogamy in Bario's population.…”

Prevalence of Various Sexually Transmitted Pathogens in Infertile Couples and Their Effects on In Vitro Fertilization Success

“…Ülkemizden 11.624 servikovajinal örneğin incelendiği bir çalışmada; HPV prevalansının %2.8 olduğu, pozitif hastaların ise yaklaşık %37'sinin çoklu HPV genotipi ile infekte olduğu bildirilmiştir. Çalışmada en sık HR HPV tiplerinin HPV 16, 31, 51 ve 52 tipleri olduğu bildirilmiştir [15] . Golob ve arkadaşları dış genital bölgede %37.1 ve semende %13.6, Schillaci ve arkadaşları ise semen örneklerinde %7.8 oranında HPV-DNA pozitifliği saptamışlardır [16,17] .…”