Estimation of the Microcirculatory Response to the Effect of Cold Helium Plasma

Мартусевич, А. К.; Krasnova, S.Yu.; Galka, A. G.; Peretyagin, P. V.; Yanin, D. V.; Костров, А. В.

doi:10.1134/s0006350919040110

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…Interestingly, there are relatively few studies to date aimed at assessing the metabolic effects of noble gases. In the literature, it is believed that inert gases [4,[16][17][18], which do not have the ability to react with other compounds, cause only minimal local effects, including only short-term shifts in the functioning of the microcirculatory bed [19]. On the contrary, helium-and argon-induced changes in metabolic processes are described only in isolated studies [16,17,[20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…The experiments carried out to evaluate the systemic effects of inert gases (using the example of helium and argon) allowed us to establish that the gases in question contribute to the formation of a special reaction of oxidative metabolism [13,[16][17][18][20][21][22][23][24][25]. In particular, the use of helium flux is a «milder» agent, only moderately but significantly enhancing free radical oxidation, but to a predominant extent increasing the antioxidant potential [12,13,19,21,24]. This is due to adaptive stimulation of the catalytic activity of the main antioxidant enzymes-catalase and superoxide dismutase; however, their induction does not go beyond physiological limits [13].…”

Section: Discussionmentioning

confidence: 99%

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Some Beneficial Effects of Inert Gases on Blood Oxidative Metabolism: In Vivo Study

Мартусевич

Surovegina

Поповичева

et al. 2022

BioMed Research International

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The aim of the study was to assess the effect of external use of inert gases (helium and argon) on the state of free radical processes in vivo. The experiment was performed on 30 male Wistar stock rats (age-3 months, weight–200-220 g.), randomly distributed into 3 equal groups. The first group of animals was intact ( n = 10 ). The animals of the second and third groups were treated with argon and helium streams, respectively. Our research has allowed us to establish that the studied inert gases have a modulating effect on the state of oxidative metabolism of rat blood, and the nature of this effect is directly determined by the type of gas. The results of this study allowed us to establish the potential antioxidant effect of the helium stream, mainly realized due to the activation of the catalytic properties of the enzymatic link of the antioxidant system of rat blood plasma. At the same time, the revealed features of shifts in oxidative metabolism during treatment with argon flow include not only stimulation of the antioxidant system but also the pronounced induction of free radical oxidation. Thus, the conducted studies made it possible to verify the specificity of the response of the oxidative metabolism of blood plasma to the use of inert gases, depending on their type.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Some Beneficial Effects of Inert Gases on Blood Oxidative Metabolism: In Vivo Study

Мартусевич

Surovegina

Поповичева

et al. 2022

BioMed Research International

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“…They were analyzed when exposed to a cold plasma stream on a section of pre-epilated skin of a laboratory animal (Wistar rats). It was found that the treatment under consideration caused nonspecific (adaptive) shifts in heart rate variability [ 59 ], as well as stimulation of the intensity of blood flow through small-diameter vessels, realized mainly due to the release of NO by the vascular wall [ 60 ]. The conjugacy of the action of cold argon and helium plasma with the modulation of nitric oxide production was previously shown in experimental studies on the model of melanoma [ 61 ] and other pathological processes [ 62 ], as well as in the mechanisms of the pro-regenerative effect of the studied effect [ 63 ].…”

Section: The Authors’ Own Research In the Field Of Studying Local And...mentioning

confidence: 99%

Cold Argon Athmospheric Plasma for Biomedicine: Biological Effects, Applications and Possibilities

et al. 2022

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Currently, plasma medicine is a synthetic direction that unites the efforts of specialists of various profiles. For the successful formation of plasma medicine, it is necessary to solve a large complex of problems, including creating equipment for generating cold plasma, revealing the biological effects of this effect, as well as identifying and justifying the most promising areas of its application. It is known that these biological effects include antibacterial and antiviral activity, the ability to stimulate hemocoagulation, pro-regenerative properties, etc. The possibility of using the factor in tissue engineering and implantology is also shown. Based on this, the purpose of this review was to form a unified understanding of the biological effects and biomedical applications of argon cold plasma. The review shows that cold plasma, like any other physical and chemical factors, has dose dependence, and the variable parameter in this case is the exposure of its application. One of the significant characteristics determining the specificity of the cold plasma effect is the carrier gas selection. This gas carrier is not just an ionized medium but modulates the response of biosystems to it. Finally, the perception of cold plasma by cellular structures can be carried out by activating a special molecular biosensor, the functioning of which significantly depends on the parameters of the medium (in the field of plasma generation and the cell itself). Further research in this area can open up new prospects for the effective use of cold plasma.

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“…To date, it has been convincingly shown that cold plasma is a universal bioregulator with a wide range of biological effects [1][2][3]. Among them, in particular, are antibacterial1, [4][5][6], antiviral and fungicidal action [7][8][9], the ability to activate hemocoagulation [10], a positive effect on regenerative processes [5,11,12], etc. On this basis, it is assumed that the cold plasma of atmospheric pressure can be used as a basis for the creation of innovative biomedical and veterinary technologies, as well as biotechnologies (for example, to increase the yield of some crops, combat plant diseases, etc.…”

Section: Introductionmentioning

confidence: 99%

Microwave study of the effect of cold argon plasma on functional state of rat’s skin

Martusevich,

Nazarov,

Surovegina

et al. 2024

BIO Web Conf.

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The purpose of this study was a comparative study of the dielectric parameters of rat skin when treated with argon and argon cold plasma. The experiment was performed on 40 male Wistar rats divided into 4 equal groups. The first group of animals (n=10) was a control (intact). The rats of the remaining groups (n=10 in each) were treated daily with a pre-epilated area of the skin of the back (area = 1x1 cm). The duration of the course for all experienced groups is 10 procedures. Animals of the second group were treated with a non–ionized argon stream (the duration of one procedure was 1 minute), rats of the third and fourth groups were treated with argon cold plasma (1 and 2 minutes, respectively). Cold plasma generation was performed using a device using the principle of microwave ionization of a gas stream. Argon of high purity (99.99%) was used as the latter. The dielectric parameters of the skin of animals in the treated area (in control group rats – at a similar point in the back) were evaluated upon completion of a full course of exposure. For this purpose, a specialized software and hardware complex was used, providing near-field resonant microwave probing of biological tissues. It was found that the course treatment of the skin of the back of rats with gas streams with different ionization causes the formation of a specific functional-metabolic and morpho-structural response. Its character is determined by the parameters of the gas flow used: non-ionized argon significantly reduces the dielectric parameters (permeability and conductivity), and the result of the action of cold argon plasma depends on the exposure. During one-minute treatment, tissue permeability was observed to remain intact with a moderate decrease in conductivity. In the case of an increase in the exposure time to 2 minutes, the dielectric constant increased, and the conductivity remained unchanged.

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Estimation of the Microcirculatory Response to the Effect of Cold Helium Plasma

Cited by 5 publications

References 14 publications

Some Beneficial Effects of Inert Gases on Blood Oxidative Metabolism: In Vivo Study

Some Beneficial Effects of Inert Gases on Blood Oxidative Metabolism: In Vivo Study

Cold Argon Athmospheric Plasma for Biomedicine: Biological Effects, Applications and Possibilities

Microwave study of the effect of cold argon plasma on functional state of rat’s skin

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