Estimation of genetic parameters for melanoma in the Old Kladruber horse

Vostrý, L.; Hofmanová, B.; Vydrová, Hana Vostrá; Přibyl, J.; Majzlík, I.

doi:10.17221/5134-cjas

Cited by 6 publications

(5 citation statements)

References 16 publications

(19 reference statements)

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“…Solkner et al (2004) reported h 2 of 0.36 for Lipizzan horses over 6 years G = Generale, G-Gss = Generale-Generalissimus, F-Gss = Favory-Generalissimus, F = Favory, S = Sacramoso, R = Rudolfo mean values on the diagonal, differences between lines above the diagonal *significant difference, **highly significant difference Curik et al (2013) stated a narrow sense total heritability h 2 = 0.37. In the threshold model by Vostry et al (2012) low heritability (h 2 = 0.11 ± 0.05) for melanoma in OKH was estimated.…”

Section: Resultsmentioning

confidence: 99%

Characterization of greying, melanoma, and vitiligo quantitative inheritance in Old Kladruber horses

Hofmanová¹,

Vostrý²,

Majzlík³

et al. 2015

Czech J. Anim. Sci.

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ABSTRACT:The paper deals with the greying process, melanoma, and vitiligo depigmentation occurrence in Old Kladruber horses (OKH). The study includes 376 animals of both sexes at the age of 1-25 years. The evaluation was performed repeatedly during 4 consecutive years. The greying status was measured spectrophotometrically on four body parts using L*a*b* colour system. Melanoma and vitiligo were detected visually and by palpation in all the animals and classified using 5 (3) grade scale. The GLM procedure of SAS package was used to examine the influence of the effects of line, age, sex, stud, and year of evaluation. The GLM analysis confirmed a significant impact of age on greying. Parameter L* showed progressive increase until 10 years of age when all horses reached final grey level. Subsequent analyses suggested the influence of sex, i.e. a notably higher level of greying in mares. The incidence of melanoma was confirmed. Melanoma in OKH most frequently occurs on the bottom of the tail or at the anal and perineal area. Probably only benign forms of melanoma have been detected. The global occurrence of melanoma in OKH (ca. 13%) is substantially lower than in Lipizzan and Camargue horses. Overall incidence of melanoma in horses at the age of 15 and older reached 68%. Genetic parameters were estimated for melanoma grade, grey level, and vitiligo. Greying is strictly influenced by age (h 2 = 0.52 ± 0.07). Prevalence of melanoma progresses with age (h 2 = 0.07 ± 0.04). Vitiligos of both facial and anal parts are influenced by the effects studied (h 2 = 0.20 ± 0.05 and 0.34 ± 0.06 for vitiligo A and vitiligo F, respectively).

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Section: Resultsmentioning

confidence: 99%

Characterization of greying, melanoma, and vitiligo quantitative inheritance in Old Kladruber horses

Hofmanová¹,

Vostrý²,

Majzlík³

et al. 2015

Czech J. Anim. Sci.

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“…The heritability estimate from the T-LM model was twice as large as estimates from the other models, and its standard errors also were doubled. Higher heritability estimates from threshold compared to linear models were also reported by Hansen et al (2004); and threshold models have resulted in higher genetic parameter estimates than linear models for body conformation (Vesela et al 2011) and health status traits (Silvestre et al 2007;Vostry et al 2012a, b). However, estimated heritability in the present work may not be a realistic heritability.…”

Section: Resultsmentioning

confidence: 53%

Comparison of models for estimating genetic parameters and predicting breeding values for birth weight and calving ease in Czech Charolais cattle

Vostrý¹,

Veselá²,

Svitáková³

et al. 2014

CZECH J ANIM SCI

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ABSTRACT:The most appropriate model for genetic parameters estimation for calving ease and birth weight in beef cattle was selected. A total of 27 402 field records were available from the Czech Charolais breed. For estimation of genetic parameters for calving ease and body weight, three bivariate models were tested: a linear-linear animal model (L-LM) with calving ease classified into four categories (1 -easy; 2-4 -most difficult), a linear-linear animal model (SC-LM) in which calving ease scores were transformed into Snell scores (Snell 1964) and expressed as percentage of assisted calving (ranging 0-100%), and a bivariate threshold-linear animal model (T-LM) with calving ease classified into four categories (1 -easy, 2-4 -most difficult). All tested models included fixed effects for contemporary group (herd × year × season), age of dam, sex and breed of a calf. Random effects included direct and maternal genetic effects, maternal permanent environmental effect, and residual error. Direct heritability estimates for calving ease and birth weight were, with the use of L-LM, SC-LM, and T-LM, from 0.096 ± 0.013 to 0.226 ± 0.024 and from 0.210 ± 0.024 to 0.225 ± 0.026, respectively. Maternal heritability estimates for calving ease and birth weight were, with the use of L-LM, SC-LM, and T-LM, from 0.060 ± 0.031 to 0.104 ± 0.125 and from 0.074 ± 0.041 to 0.075 ± 0.040, respectively. Genetic correlations of direct calving ease with direct birth weight ranged from 0.46 ± 0.06 to 0.50 ± 0.06 for all tested models; whereas maternal genetic correlations between these two traits ranged from 0.24 ± 0.17 to 0.25 ± 0.53. Correlations between direct and maternal genetic effects within-trait were negative and substantial for all tested models (ranging from -0.574 ± 0.125 to -0.680 ± 0.141 for calving ease and from -0.553 ± 0.122 to -0.558 ± 0.118 for birth weight, respectively), illustrating the importance of including this parameter in calving ease evaluations. Results indicate that any of the tested models could be used to reliably estimate genetic parameters for calving ease for beef cattle in the Czech Republic. However, because of advantages in computation time and practical considerations, genetic analysis using SC-LM (transformed data) is recommended.

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“…In some of the strongly affected animals, the metastases developed; however, clinical examination and other observations suggest that melanomas in these horses are clinically different to those in human patients [136]. In graying white horses from the Old Kladruber strain, melanomas usually naturally occur at the age of 5–6 years, and statistically significant differences between the sire lines indicate a possible influence of heritable factors [137]. The 4.6-kb duplication in the intron of the syntaxin 17 ( STX17 ) gene was found to cause the graying in horses and is associated with a high incidence of melanoma and vitiligo-like skin depigmentation [138].…”

Section: Animal Modelsmentioning

confidence: 99%

Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma

Horák

Palanová

Čížková

et al. 2019

Genes

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National cancer databases document that melanoma is the most aggressive and deadly cutaneous malignancy with worldwide increasing incidence in the Caucasian population. Around 10% of melanomas occur in families. Several germline mutations were identified that might help to indicate individuals at risk for preventive interventions and early disease detection. More than 50% of sporadic melanomas carry mutations in Ras/Raf/mitogen-activated protein kinase (MAPK/MEK) pathway, which may represent aims of novel targeted therapies. Despite advances in targeted therapies and immunotherapies, the outcomes in metastatic tumor are still unsatisfactory. Here, we review animal models that help our understanding of melanoma development and treatment, including non-vertebrate, mouse, swine, and other mammal models, with an emphasis on those with spontaneously developing melanoma. Special attention is paid to the melanoma-bearing Libechov minipig (MeLiM). This original swine model of hereditary metastatic melanoma enables studying biological processes underlying melanoma progression, as well as spontaneous regression. Current histological, immunohistochemical, biochemical, genetic, hematological, immunological, and skin microbiome findings in the MeLiM model are summarized, together with development of new therapeutic approaches based on tumor devitalization. The ongoing study of molecular and immunological base of spontaneous regression in MeLiM model has potential to bring new knowledge of clinical importance.

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Estimation of genetic parameters for melanoma in the Old Kladruber horse

Cited by 6 publications

References 16 publications

Characterization of greying, melanoma, and vitiligo quantitative inheritance in Old Kladruber horses

Characterization of greying, melanoma, and vitiligo quantitative inheritance in Old Kladruber horses

Comparison of models for estimating genetic parameters and predicting breeding values for birth weight and calving ease in Czech Charolais cattle

Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma

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