Characterization of greying, melanoma, and vitiligo quantitative inheritance in Old Kladruber horses

Hofmanová, B.; Vostrý, L.; Majzlík, I.; Vostrá-Vydrová, Hana

doi:10.17221/8524-cjas

Cited by 12 publications

(17 citation statements)

References 23 publications

(45 reference statements)

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“…As previously published [19,24], sex and the interactions of sex with age/ coat colour and geographical area were not significantly associated with melanoma (except the interaction sex and geographical area in S2). In the Camargue breed, a higher prevalence of melanoma was found in geldings compared with mares and stallions, but the differences were not statistically significant [21].…”

Section: Discussionsupporting

confidence: 68%

“…This is the first time that over 10,000 horses have been analysed. Despite the fact that heritability for the grey population was within the range of previous studies for MVS and MS outcomes [7,17,19], it was out of range for non-grey horses. This suggests the most severe forms of these diseases have less heritability, with an increased role of environmental effects, which is not the case in their most benign forms [17,22,26,27].…”

Section: Discussioncontrasting

confidence: 55%

“…described [3,7,17,19,21]. Melanoma can also affect young animals of any coat colour such as melanocytic naevi.…”

Section: Discussionmentioning

confidence: 99%

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Genetic and environmental risk factors for vitiligo and melanoma in Pura Raza Español horses

Sánchez‐Guerrero

Solé

Azor

et al. 2019

Equine Veterinary Journal

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Summary Background Vitiligo and melanoma are relatively common disorders in grey Pura Raza Español horses and other horse breeds with grey‐coloured coats. Objectives To determine the breed prevalence, environmental risks factors and estimate the genetic parameters for vitiligo and melanoma in Pura Raza Español horses. Study design Retrospective cohort study. Methods We analysed data from a large worldwide population of Pura Raza Español horses. The database included the vitiligo and melanoma scores, on either a four‐ or six‐point linear scale, of 11,436 horses. Genetic parameters were estimated using a Bayesian genetic animal model including the four associated environmental risk factors as systematic effects. Inbreeding was used as a covariate, and animal and residual effects were included as random effects. Results Of the horses included in the study, 2.8 and 20.5% showed some traces of vitiligo around the eyes and mouth, respectively, while 1.6% showed varying degrees of melanoma. Age, coat colour and inbreeding were significantly associated with the three outcomes studied. The estimated heritability for the whole population was 0.09 (s.d. +0.019), 0.44 (s.d. +0.031) and 0.13 (s.d. +0.037), for eye vitiligo score, nostril vitiligo score and melanoma scores respectively. The genetic correlations ranged from 0.42 (s.d. +0.084) between eye and nostril vitiligo score to 0.15 (s.d. +0.096) between nostril vitiligo and melanoma. Main limitations Vitiligo scores for the perianal regions were not collected. The veterinarian responsible for each assessment was not recorded. Conclusions Vitiligo and melanoma are prevalent in this population and those environmental risk factors and genetics both have an effect on the clinical expression of the diseases. These findings may help to reduce prevalence through breeding programmes.

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Section: Discussionsupporting

confidence: 68%

Section: Discussioncontrasting

confidence: 55%

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Genetic and environmental risk factors for vitiligo and melanoma in Pura Raza Español horses

Sánchez‐Guerrero

Solé

Azor

et al. 2019

Equine Veterinary Journal

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“…Therefore, an association between the coat colour paint and the presence of FFL cannot be confirmed from the results in the current study. It has been suggested that grey horses may be more prone to show FFL due to the higher risk of melanoma [19], which may cause defecation difficulties, but no such association has been identified in the literature or in this study. Social stress has been suggested to play a role for the presence of FFL, as the majority of FFL-affected horses did not defend their feed against other horses and were judged as low in the hierarchy in a previous study [1].…”

Section: Horsescontrasting

confidence: 64%

Differential Defecation of Solid and Liquid Phases in Horses—A Descriptive Survey

Lindroth

Johansen

Båverud

et al. 2020

Animals

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Free faecal liquid (FFL) is a condition in horses where faeces are voided in one solid and one liquid phase. The liquid phase contaminates the tail, hindlegs and area around the anus of the horse, resulting in management problems and potentially contributing to impaired equine welfare. The underlying causes are not known, but anecdotal suggestions include feeding wrapped forages or other feed- or management-related factors. Individual horse factors may also be associated with the presence of FFL. This study, therefore, aimed to characterize horses showing FFL particularly when fed wrapped forages, and to map the management and feeding strategies of these horses. Data were retrieved by a web-based survey, including 339 horses with FFL. A large variety of different breeds, ages, disciplines, coat colours, housing systems and feeding strategies were represented among the horses in the study, meaning that any type of horse could be affected. Respondents were asked to indicate if their horse had diminished signs of FFL with different changes in forage feeding. Fifty-eight percent (n = 197) of the horse owners reported diminished signs of FFL in their horses when changing from wrapped forages to hay; 46 (n = 156) of the horse owners reported diminished signs of FFL in their horses when changing from wrapped forages to pasture; 17% (n = 58) reported diminished signs of FFL when changing from any type of forage batch to any other forage. This indicated that feeding strategy may be of importance, but cannot solely explain the presence of FFL. The results also showed that the horses in this study had a comparably high incidence of previous colic (23%, n = 78) compared to published data from other horse populations. In conclusion, the results showed that FFL may affect a large variety of horse types and that further studies should include detailed data on individual horse factors including gastrointestinal diseases as well as feeding strategies, in order to increase the chance of finding causes of FFL.

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“…This breed, with unique characteristics and high cultural and historical value (Vostra-Vydrova et al 2016), is an important gene resource of the Czech Republic and the population has been fully closed since 2002 (Hofmanova et al 2015). Since the population of this gene resource breed is small, preservation of breeding material (i.e.…”

mentioning

confidence: 99%

Effect of two freezing extenders on characteristic of fresh and frozen-thawed semen in endangered Old Kladruber stallions - A pilot study

Šichtař¹,

Nehasilová²,

Šimoník³

et al. 2017

CZECH J ANIM SCI

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ABSTRACTŠichtař J., Nehasilová A., Šimoník O., Bubeníčková F. (2017): Effect of two freezing extenders on characteristic of fresh and frozen-thawed semen in endangered Old Kladruber stallions -A pilot study. Czech J. Anim. Sci., 62, 227−233.The aim of the study was to evaluate the effect of two different extenders on sperm characteristic before equilibration and post-thaw in the endangered Old Kladruber stallions. Also, the response of individual stallions to the extenders used was tested. Semen was collected from six stallions every other day within one week. After centrifugation of the collected sperm-rich fraction, the supernatant was removed and sperm pellets were divided to two aliquots; these were diluted either with Gent (Minitube, Germany) or privately manufactured lactose-EDTA-egg yolk extender (Lact). Three cryopreserved insemination doses (IDs) from each extender (Gent and Lact) were prepared for each stallion from one collection (108 samples from six stallions in total). As a parameter of quality, the motility (computer assisted sperm analysis), viability (fluorescence staining), and morphology (eosin/nigrosine staining) were evaluated after dilution with freezing extenders (fresh) and after thawing (frozen-thawed). The different effects of chosen extenders on the quality of fresh semen were only manifested in higher kinematic parameters of sperm when the Lact extender was used. However, in frozen-thawed samples, the Gent extender yielded significantly better results in all of the evaluated parameters. The representation of sperm subpopulation was significantly influenced by extender in fresh as well as frozen-thawed samples; moreover, we found a significant effect of freezing on the distribution of these subpopulations. The response of individual stallions to chosen extenders was evident in the different quality of fresh as well as frozen-thawed IDs; Gent extender yielded better frozen-thawed IDs. Based on our results, among others describing quality parameters of ejaculate in endangered Old Kladruber stallions, we can recommend using Gent extender for the production of frozen-thawed IDs.

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Characterization of greying, melanoma, and vitiligo quantitative inheritance in Old Kladruber horses

Cited by 12 publications

References 23 publications

Genetic and environmental risk factors for vitiligo and melanoma in Pura Raza Español horses

Genetic and environmental risk factors for vitiligo and melanoma in Pura Raza Español horses

Differential Defecation of Solid and Liquid Phases in Horses—A Descriptive Survey

Effect of two freezing extenders on characteristic of fresh and frozen-thawed semen in endangered Old Kladruber stallions - A pilot study

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