Estimation of flock/herd-level true Mycobacterium avium subspecies paratuberculosis prevalence on sheep, beef cattle and deer farms in New Zealand using a novel Bayesian model

Verdugo, Cristóbal; Jones, Geoff; Johnson, W.; Wilson, Peter R.; Stringer, Lesley; Heuer, C

doi:10.1016/j.prevetmed.2014.10.004

Cited by 27 publications

(14 citation statements)

References 33 publications

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“…In this study the term OJD refers to clinical disease, usually resulting in mortality. Map infection is widespread in New Zealand with at least 75% of sheep flocks infected [ 3 ]. About 2–6% of flocks were believed to be clinically affected [ 4 ] and annual incidence of clinical disease within affected flocks was estimated to be about 1% or lower [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Economic Cost of Ovine Johne’s Disease in Clinically Affected New Zealand Flocks and Benefit-Cost of Vaccination

Gautam

Anderson

Ridler

et al. 2018

Veterinary Sciences

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The aims of this study were to estimate the on-fam economic cost of ovine Johne’s disease (OJD) based on collected incidence and mortality data, and the benefit-cost of OJD vaccination in typical OJD affected flocks in New Zealand after having vaccinated for a number of years. Owners of 20 sheep breeding and finishing farms known to be clinically affected by ovine Johne’s disease in New Zealand participated in the study and were monitored for up to two years. Farms were categorized as fine-wool (Merino, Half-Bred, Corriedale, n = 15), and other breeds (Romney, composite breeds, n = 5). Ovine JD was confirmed by gross- and histo-pathology in 358 ewes culled due to chronic progressive wasting. An additional 228 ewes with low body condition score (BCS), but not targeted for culling, were tested with ELISA to estimate the proportion of OJD in ewes in the lower 5% BCS of the flock. Calculations were done separately for fine-wool and other breeds. Based on the data, mortality due to OJD, its associated cost and the benefit-cost of vaccination were evaluated for a hypothetical farm with 2000 ewes by stochastic simulation. Total ewe mortality was similar in fine-wool and other breeds, but the estimated mortality due to OJD was 2.7 times as high in fine-wool (median 1.8%, interquartile range IQR 1.2–2.7%) than other breeds (median 0.69%, IQR 0.3–1.2%), but with large variation between farms. ELISA results demonstrated fine-wool sheep had a higher seroprevalence than other breeds (39%, 95% CI 18–61% vs. 9%, 95% CI 0–22%). Stochastic modelling indicated that the average annual cost of mortality due to OJD in a flock of 2000 ewes was NZD 13,100 (IQR 8900–18,600) in fine-wool and NZD 4300 (IQR 2200–7600) in other breeds. Vaccinating replacement lambs against OJD may be cost-effective in most flocks when the pre-vaccination annual ewe mortality due to OJD is >1%. To make the best-informed decision about vaccination it is therefore essential for farmers to accurately diagnose OJD to establish incidence.

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Section: Introductionmentioning

confidence: 99%

Economic Cost of Ovine Johne’s Disease in Clinically Affected New Zealand Flocks and Benefit-Cost of Vaccination

Gautam

Anderson

Ridler

et al. 2018

Veterinary Sciences

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“…paratuberculosis (Map) that affects ruminants. The disease is the most important infection of domestic ruminants affecting worldwide and responsible for substantial economic losses (Verdugo et al, 2014). The most important factor to achieve the eradication of this chronic disease is the difficult of ante-mortem diagnostic tests to detect animals during its latent period prior to their becoming infectious.…”

Section: Introductionmentioning

confidence: 99%

Detection of Mycobacterium avium subsp. paratuberculosis by several diagnostics techniques in clinical suspected sheep

Coelho

Coelho²,

García‐Díez

et al. 2018

J Hellenic Vet Med Soc

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A total of thirty sheep with clinical symptomatology of paratuberculosis (Johne’s disease) were subjected to four diagnostic techniques: histopathological examination, bacteriological culture (in faeces and tissues), polymerase chain reaction (PCR) (in blood, tissue and faecal samples) and antibody responses (ELISA). Twenty-one (70.0%) animals showed histological lesions. Bacterial culture of both faeces and tissue revealed that 2 (6.7%) and 6 (20.0%) of the 30 sheep were infected, respectively. Mycobacterium avium subsp. 24 paratuberculosis (Map) was identified in 4 animals via PCR of faeces (13.3%), and in 19 (63.3%) by PCR in tissues. PCR in blood revealed 7 (23.3%) infected animals. Three (10.0%) animals showed antibodies against Map. A greater number of positive animals were detected by histopathological examination and PCR in tissues than by culture or ELISA. This study confirmed the clinical findings and results suggest that histopathology, PCR in tissues and in blood can improve the detection of Map in physically suspected animals and should be considered useful tools in the diagnosis of Map in suspected sheep.

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“…In the laboratory, a diagnosis can be made by isolating the agent from feces or necropsy material, by histological study of the lesions, and polymerase chain reaction (PCR) assays. By using the Ziehl-Neelsen staining method (ZN-test), acid-alcohol resistant bacteria are observed in feces smears and at the end portions of the small intestine, however, serum-ELISA has been referred as superior to the ZN-test to confirm the presumptive diagnosis of clinical paratuberculosis in cattle (Weber et al, 2009). Subclinical cases can be diagnosed by isolating the bacteria from the feces, serological tests, or allergy tests (Lilenbaum et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…In this context, the performance of epidemiological studies to investigate infectious agents as well as infection by MAP is important. MAP prevalence estimation is a key element to assess the disease impact, and for the design of control programmes (Verdugo et al, 2014), therefore, the objective of this study was to determine the herd-level and animal-level prevalence of MAP infection using serology in cattle from the State of Paraíba, Northeastern Brazil, as well as to identify risk factors associated with herd-level prevalence.…”

Section: Introductionmentioning

confidence: 99%

Herd-level prevalence and associated risk factors for Mycobacterium avium subsp. paratuberculosis in cattle in the State of Paraíba, Northeastern Brazil

Vilar

Santos

Pimenta

et al. 2015

Preventive Veterinary Medicine

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Estimation of flock/herd-level true Mycobacterium avium subspecies paratuberculosis prevalence on sheep, beef cattle and deer farms in New Zealand using a novel Bayesian model

Cited by 27 publications

References 33 publications

Economic Cost of Ovine Johne’s Disease in Clinically Affected New Zealand Flocks and Benefit-Cost of Vaccination

Economic Cost of Ovine Johne’s Disease in Clinically Affected New Zealand Flocks and Benefit-Cost of Vaccination

Detection of Mycobacterium avium subsp. paratuberculosis by several diagnostics techniques in clinical suspected sheep

Herd-level prevalence and associated risk factors for Mycobacterium avium subsp. paratuberculosis in cattle in the State of Paraíba, Northeastern Brazil

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