Estimation of Cefditoren Pivoxil in Pharmaceutical Oral Solid Dosage form by Spectrophotometry

Niraimathi, V.; Prema, V.; Aruna, Ajithadas; Suresh, A. Jerad

doi:10.18579/jpcrkc/2010/9/2/79486

Cited by 4 publications

(5 citation statements)

References 2 publications

(2 reference statements)

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“…Thus, its pharmaceutical dosage form (Meiact® 200 mg/tablet) was subjected to the analysis of its CTP content by the proposed enhanced AgNP SIA‐CL method. The obtained results were presented in Table and statistically compared by Student's t ‐test and F ‐test with those obtained from the reported spectrophotometric method . The results did not reveal any significant difference between them at 95% confidence level proving similar accuracy and precision.…”

Section: Resultsmentioning

confidence: 93%

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Application of silver nanoparticles to the chemiluminescence determination of cefditoren pivoxil using the luminol–ferricyanide system

2014

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A new simple, accurate and sensitive sequential injection analysis chemiluminescence (CL) detection method for the determination of cefditoren pivoxil (CTP) has been developed. The developed method was based on the enhancement effect of silver nanoparticles on the CL signal arising from a luminol-potassium ferricyanide reaction in the presence of CTP. The optimum conditions relevant to the effect of luminol, potassium ferricyanide and silver nanoparticle concentrations were investigated. The proposed method showed linear relationships between relative CL intensity and the investigated drug concentration at the range 0.001-5000 ng/mL, (r = 0.9998, n = 12) with a detection limit of 0.5 pg/mL and quantification limit of 0.001 ng/mL. The relative standard deviation was 1.6%. The proposed method was employed for the determination of CTP in bulk drug, in its pharmaceutical dosage forms and biological fluids such as human serum and urine. The interference of some common additive compounds such as glucose, lactose, starch, talc and magnesium stearate was investigated. In addition, the interference of some related cephalosporins was tested. No interference was recorded. The obtained sequential injection analysis-CL results were statistically compared with those from a reported method and did not show any significant differences.

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Section: Resultsmentioning

confidence: 93%

“…A literature survey revealed that few analytical methods have been reported including high‐performance liquid chromatography , gas chromatography , high‐performance thin‐layer chromatography , spectrophotometry and potentiometry .…”

Section: Introductionmentioning

confidence: 99%

Application of silver nanoparticles to the chemiluminescence determination of cefditoren pivoxil using the luminol–ferricyanide system

2014

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“…40 The reported melamine content in commercially available milk sample from the state Tamilnadu in India is 0.028−0.071 mg/ kg or in the range of 0.2−0.58 μM. 41 SHPPSI MS provides an easy and direct detection method of melamine in milk samples without having the sample processing step (Figure 6). The experiment was conducted by arbitrarily spiking a 5 nM (or 0.63 ppb) concentration of melamine in a melamine free milk sample, purchased from the local market.…”

Section: Detectionmentioning

confidence: 99%

Sub-Parts-per-Trillion Level Detection of Analytes by Superhydrophobic Preconcentration Paper Spray Ionization Mass Spectrometry (SHPPSI MS)

2019

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A new kind of ambient ionization method named superhydrophobic preconcentration paper spray ionization mass spectrometry (SHPPSI MS) is introduced, where superhydrophobicity and paper spray mass spectrometry (PS MS) are coupled. The SHPPSI MS requires only microliter amounts of analyte solutions, allows easy sampling procedure, and provides high sensitivity for a diverse array of analytes. It can be used to detect food adulteration at extremely low concentrations. The experimental methodology involves modifying one of the surfaces of a triangularly cut filter paper to make it acquire low surface energy by drop casting a green and ecofriendly superhydrophobic coating material over it followed by drying. A micrometer scale defect was made at close proximity to one of the tips of the paper using a pin. Preconcentration of the sample was accomplished by allowing a 10 μL droplet of an aqueous solution of the analyte to stand at the defect followed by drying naturally. The dried paper was used as the substrate for paper spray mass spectrometry by eluting the analyte with a suitable solvent. This novel technique was used to detect melamine in adulterated milk, whose detection at the ppt level in milk normally needs sophisticated instruments, a larger amount of sample, and a complex sampling procedure, including further purification and separation. The SHPPSI MS detects melamine directly from milk at the sub-ppb level by simply putting a microdroplet of adulterated milk at the substrate and eluting the sample with methanol. This paperbased technique can be a promising tool for direct sensing of analytes such as drugs in body fluids, pesticides in water and soil, etc.

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“…Literature includes various methods for determination of CTP either in plasma [2][3][4] or in pharmaceutical dosage forms by various spectrophotometric methods [5][6][7]. Different stability indicating HPLC [8][9][10], UPLC [11] and HPTLC [12] methods were also reported.…”

Section: Introductionmentioning

confidence: 99%

Quality by Design Approach for Establishment of Stability Indicating Method for Determination of Cefditoren Pivoxil

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et al. 2018

J Pharm Anal Insights

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Estimation of Cefditoren Pivoxil in Pharmaceutical Oral Solid Dosage form by Spectrophotometry

Cited by 4 publications

References 2 publications

Application of silver nanoparticles to the chemiluminescence determination of cefditoren pivoxil using the luminol–ferricyanide system

Application of silver nanoparticles to the chemiluminescence determination of cefditoren pivoxil using the luminol–ferricyanide system

Sub-Parts-per-Trillion Level Detection of Analytes by Superhydrophobic Preconcentration Paper Spray Ionization Mass Spectrometry (SHPPSI MS)

Quality by Design Approach for Establishment of Stability Indicating Method for Determination of Cefditoren Pivoxil

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