Application of silver nanoparticles to the chemiluminescence determination of cefditoren pivoxil using the luminol–ferricyanide system

Abstract

A new simple, accurate and sensitive sequential injection analysis chemiluminescence (CL) detection method for the determination of cefditoren pivoxil (CTP) has been developed. The developed method was based on the enhancement effect of silver nanoparticles on the CL signal arising from a luminol-potassium ferricyanide reaction in the presence of CTP. The optimum conditions relevant to the effect of luminol, potassium ferricyanide and silver nanoparticle concentrations were investigated. The proposed method showed linear relationships between relative CL intensity and the investigated drug concentration at the range 0.001-5000 ng/mL, (r = 0.9998, n = 12) with a detection limit of 0.5 pg/mL and quantification limit of 0.001 ng/mL. The relative standard deviation was 1.6%. The proposed method was employed for the determination of CTP in bulk drug, in its pharmaceutical dosage forms and biological fluids such as human serum and urine. The interference of some common additive compounds such as glucose, lactose, starch, talc and magnesium stearate was investigated. In addition, the interference of some related cephalosporins was tested. No interference was recorded. The obtained sequential injection analysis-CL results were statistically compared with those from a reported method and did not show any significant differences.

Rapid and Sensitive Electrochemical Assay of Cefditoren with MWCNT/Chitosan NCs/Fe2O3 as a Nanosensor

“…Several analytical techniques have been performed for the determination of cefditoren, including LC-MS techniques [2], voltammetrics [3], spectrophotometry [4][5][6], chemiluminescence [7], micellar liquid chromatography [8], high-performance liquid chromatography (HPLC) [5,[9][10][11][12][13], Fourier transform infrared spectroscopy [14], potentiometry using ion-selective electrodes [15], and thin-layer chromatography (TLC) [5]. Electrochemical techniques are significant for monitoring and sensing pharmaceuticals because of their specific properties such as a fast response, sensitivity, no pre-treatment, simplicity, low organic solvent consumption, and low cost versus traditional analysis methods [16].…”

Application of a fluorescent biosensor based‐on magneto‐γ‐Fe2O3–methyldopa nanoparticles for adsorption of human serum albumin

“…At present, there are many reports for the determination of biomolecules, such as IgE , myoglobin , dopamine , C‐reactive protein , procaterol hydrochloride , cefditoren pivoxil , nicotinamide by using analytical methods. Quantification of albumin is clinically important, as it has been found to be an effective prognostic indicator.…”