Estimation of antinociceptive and anti-inflammatory activity on Geranium pratense subsp. finitimum and its phenolic compounds

Küpeli, Esra; Tatlı, I. İrem; Akdemir, Zeliha Ş.; Yeşilada, Erdem

doi:10.1016/j.jep.2007.08.005

Cited by 43 publications

(32 citation statements)

References 18 publications

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“…Many others biological activities for these flavonoid glycosides have been described, including antioxidant (compounds 1 and [66,67] amoebicidal, spasmogenic and giardicidal (compound 1), [68] antilipoxygenase (compound 2), [69] analgesic (compound 2), [70] antiviral (compounds 1 [71] and 4 [59] ), anti-inflamatory (compounds 1, 2 and 4), [72] and tissue thromboplastin inhibitory (compounds 1, 3 and 4). [73] DOSY NMR has found many uses in chemical research as can be seen in numerous reports in the literature.…”

Section: Resultsmentioning

confidence: 99%

DOSY NMR applied to analysis of flavonoid glycosides from Bidens sulphurea

Rodrigues¹,

Silva²,

Oliveira³

et al. 2009

Magnetic Reson in Chemistry

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2D DOSY 1H NMR has proved to be a useful technique in the identification of the molecular skeleton of the four major compounds of ethyl acetate extract of aerial parts of Bidens sulphurea (Asteraceae). The combination of this technique with HPLC, mass spectrometry and other NMR techniques enabled the identification of four flavonoid glycosides: quercetin-3-O-beta-D-galactopyranoside, quercetin-3-O-beta-D-glycopyranoside, quercetin-3-O-alpha-L-arabinofuranoside and quercetin-3-O-beta-D-rhamnopyranoside.

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Section: Resultsmentioning

confidence: 99%

DOSY NMR applied to analysis of flavonoid glycosides from Bidens sulphurea

Rodrigues¹,

Silva²,

Oliveira³

et al. 2009

Magnetic Reson in Chemistry

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“…The carrageenan-induced hind paw edema model was used to determine the anti-inflammatory activity 42 . Each group contained a minimum of six animals.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Design and synthesis of stable n-[2-(aryl/heteroaryl substituted)ethyl] propanamide derivatives of (s)-ketoprofen and (s)-ibuprofen as non-ulcerogenic anti-inflammatory and analgesic agents

Berk¹,

Bender²,

Küpeli³

et al. 2016

actapharm

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“…Many classic texts of oriental medicine showed the name of GSL as a medicine for healing of bacteria, intestinal inflammation, dermatitis, diarrhea, and cancer (Guo et al, 1987;Lee et al, 1993;Cho, 2006). Recent studies have reported that a number of phenolic compounds isolated from various Geranium species have antinociceptive and anti-inflammatory effects in inflammatory animal model systems (Küpeli et al, 2007;Pokharel et al, 2007). Among phenolic compounds, 4-hydroxykobusin isolated from Geranium thunbergii inhibits the production of nitric oxide and expression of inducible nitric oxide synthase (iNOS) via transcriptional activations of NF-B and AP-1 in macrophage cells (Pokharel et al, 2007).…”

Section: Introductionmentioning

confidence: 99%