Introduction: Cancer is one of the leading causes of mortality in México and is expected to rise in the next years mostly because of an aging population. Nevertheless, only a few comprehensive studies of cancer mortality have been published recently. Objective: Provide an update of the cancer mortality in México. Material y methods: We analyzed official death certification using data-base from Instituto Nacional Estadística y Geografía (INEGI) and population trends from Consejo Nacional de Población (CONAPO). Results: There were 85,201 deaths from cancer in México in 2015 with an overall estimated rate 70.5/105 (men 70.6/105 and women 70.1/105). From 2010 to 2015, overall cancer mortality estimated rate has increased by 5.4% from 66.6 to 70.5/105. The first five types of cancer cause of death were: prostate 10.9/105, breast 10.1/105, cervical cancer 6.4/105, lung 5.7/105 and liver 5.2/105. Death rates for lung and cervical cancers have decreased since year 2000. Conclusions: Cancer mortality rates are still increasing in México, although, some types of cancer rates are beginning to stabilize. Prostate cancer is the leading cause of cancer death in México.