Establishment of a cut‐point value of serum TNF‐α levels in the metabolic syndrome

Abstract

Cardiovascular diseases and type 2 diabetes are the major causes of mortality in Mexico. Metabolic syndrome (MS) is a cluster of factors that increase the risk to develop such diseases. Previous studies have shown that MS is associated with high tumor necrosis factor (TNF-a) levels. In fact, TNF-a has been proposed to be a useful marker for clinical diagnosis of inflammation at an early stage. Therefore, we analyzed TNF-a concentrations in Mexican individuals with or without MS and related these levels to the associated MS components. Clinical, anthropometric, and biochemical data were analyzed in 41 healthy and 39 MS individuals. Individuals were similarly grouped by age and gender.The serum TNF-a levels measured by a highly sensitive enzyme-linked immunosorbent assay (ELISA) kit were increased significantly in MS subjects compared with healthy individuals (Po0.001). The assay showed 78.1% sensitivity and 61.5% specificity with a cut-point level of 1.36 pg/mL. TNF-a levels higher than the cut-point value were correlated with insulin resistance indices. These findings support the hypothesis that serum TNF-a concentration could be a useful marker for early MS diagnosis. Nevertheless, we suggest the establishment of specific cut-point values in each studied population to evaluate potential clinical applications.

Effect of the Mediterranean Diet With and Without Weight Loss on Markers of Inflammation in Men With Metabolic Syndrome

“…These mechanisms may partly explain the reduced plasma CRP concentrations with MedDiet in the absence of weight loss even when other proinflammatory cytokines are not significantly altered. Although in our study plasma IL-18 concentrations on the control diet were comparable to those obtained in other populations with MetS, plasma IL-6 and TNF-a concentrations were much lower (about 40-50%) and this may also account for the lack of effect of the MedDiet without weight loss on these proinflammatory markers (11,29,30). Finally, we cannot exclude the possibility that the small reduction observed in plasma IL-6, IL-18, and TNF-a would have been significant with a greater number of subjects.…”

Anti‐inflammatory effect of water extracts of Graptopetalum paraguayense supplementation in subjects with metabolic syndrome: a preliminary study

“…MS is considered to be a chronic inflammatory status. Previous studies reported that the subjects with MS have a higher inflammation status and that a higher level of CRP (≥1.0 mg L −1 ), IL‐6 (≥1.5 pg L −1 ), or TNF‐α (≥1.36 pg mL −1 ) may increase the risk of MS . In the present study, in either the placebo or WGP group, subjects with MS had higher levels of inflammatory markers at baseline (Table ).…”

“…7 MS is considered to be a chronic inflammatory status. Previous studies reported that the subjects with MS have a higher inflammation status and that a higher level of CRP (≥1.0 mg L −1 ), IL-6 (≥1.5 pg L −1 ), or TNF-(≥1.36 pg mL −1 ) may increase the risk of MS. 5,23 In the present study, in either the placebo or WGP group, subjects with MS had higher levels of inflammatory markers at baseline ( Table 2). Inhibition of inflammation by antioxidants thus constitutes an important mechanism in MS. Nuclear factor-B (NF-B) is generally considered to be a pro-inflammatory transcription factor and plays a critical role in the development of inflammation.…”

Threshold serum concentrations of tumour necrosis factor alpha (TNFα) as a potential marker of the presence of microangiopathy in children and adolescents with type 1 diabetes mellitus (T1DM)

“…The findings of the study allow us to believe that it is justifiable to monitor serum TNFa concentrations in children and adolescents with T1DM during the course of the disease to predict the occurrence of diabetic microangiopathy. A similar threshold serum value for TNFa in patients with the metabolic syndrome was determined by Gurrola-Diaz et al [50]. The threshold value for serum TNFa was set at the level of 1.36 pg/ml.…”

“…The sensitivity and specificity were 78.1% and 61.5%, respectively. The authors suggest that the measurement of TNFa serum levels may be clinically useful as a prognostic marker while diagnosing the metabolic syndrome [50].…”