Threshold serum concentrations of tumour necrosis factor alpha (TNFα) as a potential marker of the presence of microangiopathy in children and adolescents with type 1 diabetes mellitus (T1DM)

Zorena, Katarzyna; Kula, Marta; Malinowska, Ewa; Raczyńska, Dorota; Myśliwiec, Małgorzata; Raczyńska, Krystyna

doi:10.1016/j.humimm.2012.10.002

Cited by 21 publications

(28 citation statements)

References 48 publications

(72 reference statements)

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“…The groups were not matched for the HLA genotype in those studies, and the investigators in the latter study reported differences in the kidney function between the cases and the controls (31), which could influence the results. Zorena et al (33) discovered that diabetic children and adolescents with signs of microangiopathy had lower sRAGE concentrations than controls, but the results in patients with type 1 diabetes without microangiopathy and controls were similar. Studies in adult populations have more consistently reported higher sRAGE concentrations in diabetic patients than healthy controls (34,35), and recently Lam et al (35) suggested that insulin could affect the sRAGE formation.…”

Section: Discussionmentioning

confidence: 98%

Decrease in Circulating Concentrations of Soluble Receptors for Advanced Glycation End Products at the Time of Seroconversion to Autoantibody Positivity in Children With Prediabetes

et al. 2015

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OBJECTIVEDietary advanced glycation end products (AGEs) and their interactions with the receptor for AGEs (RAGE) may play a role in the pathogenesis of type 1 diabetes. This study set out to assess whether there is any association of circulating concentrations of soluble RAGE (sRAGE), AGEs, and their ratio with the appearance of diabetes-associated autoantibodies in children progressing to clinical diabetes. RESEARCH DESIGN AND METHODSSerum concentrations of sRAGE, N-«(carboxymethyl)lysine (CML) adducts, and the sRAGE/CML ratio were analyzed in children who progressed to type 1 diabetes. The samples were taken at four time points: before seroconversion, at the time of the first autoantibody-positive sample, at the time of the first sample positive for multiple (>2) autoantibodies, and close to the disease diagnosis. Samples of autoantibody-negative controls matched for age, sex, and HLA-conferred diabetes risk were analyzed at corresponding time points. RESULTSThe prediabetic children had higher sRAGE concentrations before seroconversion (P c = 0.03), at the appearance of multiple autoantibodies (P c = 0.008), and close to diagnosis (P c = 0.04). Close to diagnosis, the cases had lower CML concentrations than the controls (P c = 0.004). Prediabetic children had a higher sRAGE/CML ratio than the controls before seroconversion (P c = 0.008) and at diagnosis (P c < 0.001). CONCLUSIONSPrediabetic children have higher concentrations of sRAGE and a higher sRAGE/ CML ratio than healthy controls. Circulating sRAGE concentrations seem to decline with the appearance of diabetes-predictive autoantibodies in children progressing to type 1 diabetes. The higher sRAGE/CML ratio in prediabetic children may reflect a higher AGE scavenger capacity.

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Section: Discussionmentioning

confidence: 98%

Decrease in Circulating Concentrations of Soluble Receptors for Advanced Glycation End Products at the Time of Seroconversion to Autoantibody Positivity in Children With Prediabetes

et al. 2015

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“…Correlations to plasma levels of TNF- α , IL-1 β , IL-8, and CCL2 and vitreous levels of TNF- α , IL-1, IL-6, IL-8, and CCL2 have been found for both NPDR and PDR [37, 38, 83–86]. In children and adolescents with type 1 diabetes, serum TNF- α , vascular endothelial growth factor (VEGF), AGE concentration, and urinary albumin excretion were all predictive of retinal microvascular disease [87]. Similarly Ben-Mahmud et al found a correlation between the levels of plasma TNF- α and the degree of DR in patients with either type 1 and type 2 diabetes [84].…”

Section: Molecular Mechanisms Linking Hyperglycemia and Microglialmentioning

confidence: 99%

The Role of Microglia in Diabetic Retinopathy

Grigsby¹,

Cardona

Pouw

et al. 2014

Journal of Ophthalmology

153

163

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There is growing evidence that chronic inflammation plays a role in both the development and progression of diabetic retinopathy. There is also evidence that molecules produced as a result of hyperglycemia can activate microglia. However the exact contribution of microglia, the resident immune cells of the central nervous system, to retinal tissue damage during diabetes remains unclear. Current data suggest that dysregulated microglial responses are linked to their deleterious effects in several neurological diseases associated with chronic inflammation. As inflammatory cytokines and hyperglycemia disseminate through the diabetic retina, microglia can change to an activated state, increase in number, translocate through the retina, and themselves become the producers of inflammatory and apoptotic molecules or alternatively exert anti-inflammatory effects. In addition, microglial genetic variations may account for some of the individual differences commonly seen in patient's susceptibility to diabetic retinopathy.

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“…Our previous studies and studies by other authors have shown that long-term diabetic complications occur after 5 years of the disease [1, 4, 8]. Therefore for the purpose of analyses the study patients with T1DM were divided into two subgroups: patients with duration of diabetes ≤5 years and those with disease duration >5 years.…”

Section: Discussionmentioning

confidence: 99%

“…Metabolic control of diabetes mellitus is one of the most important factors, but not the only one, that affects the risk of long-term angiopathic complications [4–7]. Several proofs of evidence indicates that the risk of long-term diabetic complications is increased when hyperglycaemia is accompanied by lipid metabolism disorders and high blood pressure values [3, 6, 8].…”

Section: Introductionmentioning

confidence: 99%

No effect of yeast-like fungi on lipid metabolism and vascular endothelial growth factor level in children and adolescents with type 1 diabetes mellitus

et al. 2016

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BackgroundThe objective of the research was to investigate vascular endothelial growth factor (VEGF) levels in the context of lipid metabolism and amount of yeast-like fungi colonizing the digestive tract in children and adolescents with type 1 diabetes mellitus (T1DM).MethodsThe study included 45 children with T1DM and 27 age- and sex-matched healthy control subjects. In the study sample 33 T1DM patients were administered insulin pump therapy and 12 T1DM patients were administered multiple daily injections with insulin pen devices. All T1DM patients were free of micro- and macrovascular complications. In T1DM patients and healthy controls biochemical tests were performed and measurements of yeast-like fungi colonizing the alimentary tract were conducted. Moreover all study subjects had their serum VEGF levels measured with ELISA test.ResultsThe subgroup of children and adolescents with T1DM and yeast-like fungus colony number 10^3 CFU/g was shown statistically significantly lower HbA1c levels, and lower but not statistically significantly total cholesterol, LDL cholesterol and VEGF levels versus T1DM patients with the amount of yeast-like fungi 10^6 CFU/g. Moreover higher HDL levels were observed in this subgroup versus T1DM patients with the amount of yeast-like fungi 10^6 CFU/g although the difference was not statistically significant.ConclusionsOur study has shown no influence of yeast-like fungi on lipid metabolism and VEGF level in children and adolescents with T1DM. Comprehensive treatment of T1DM patients and intensive insulin therapy with help of personal insulin pumps can reduce or prevent the development of long-term diabetic complications. Further studies in this field are needed.

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Threshold serum concentrations of tumour necrosis factor alpha (TNFα) as a potential marker of the presence of microangiopathy in children and adolescents with type 1 diabetes mellitus (T1DM)

Cited by 21 publications

References 48 publications

Decrease in Circulating Concentrations of Soluble Receptors for Advanced Glycation End Products at the Time of Seroconversion to Autoantibody Positivity in Children With Prediabetes

Decrease in Circulating Concentrations of Soluble Receptors for Advanced Glycation End Products at the Time of Seroconversion to Autoantibody Positivity in Children With Prediabetes

The Role of Microglia in Diabetic Retinopathy

No effect of yeast-like fungi on lipid metabolism and vascular endothelial growth factor level in children and adolescents with type 1 diabetes mellitus

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