Establishment and assessment of a rat model of fatigue

Tanaka, Masaaki; Nakamura, Fusao; Mizokawa, Shigekazu; Matsumura, Akira; Nozaki, Satoshi; Watanabe, Yasuyoshi

doi:10.1016/j.neulet.2003.08.051

Cited by 120 publications

(80 citation statements)

References 15 publications

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“…The present study demonstrated an anti-fatigue activity of RRPP in the weight-loaded forced swimming test, and a valid animal model for screening anti-fatigue agents [20]. The length of the swimming time to exhaustion indicated the degree of fatigue.…”

Section: Rrpp Prolonged the Exhaustive Swimming Timesupporting

confidence: 53%

Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae Preparata

Wang¹,

Yu²,

Liu³

et al. 2012

International Journal of Biological Macromolecules

144

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Section: Rrpp Prolonged the Exhaustive Swimming Timesupporting

confidence: 53%

Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae Preparata

Wang¹,

Yu²,

Liu³

et al. 2012

International Journal of Biological Macromolecules

144

View full text Add to dashboard Cite

“…If all these findings are put together, we may conclude that 5-HT reserve in the CA1 region of BDR rats is not adequate to generate a profound increase when stimulated and particular 5-HT receptor subtypes upregulated as a part of an adaptive mechanism. The role of hippocampus in central fatigue was also reported in other models of fatigue like keeping the rats in a wet cage and subjecting the rats to a weight-loaded forced swimming test for evaluation of the extent of fatigue (Tanaka et al, 2003). In this paper, increased 5-HT and dopamine turnover in the hippocampus, hypothalamus and in the striatum were shown, suggesting the involvement of hippocampus and hypothalamus in central fatigue (Tanaka et al, 2003).…”

Section: Discussionsupporting

confidence: 63%

“…The role of hippocampus in central fatigue was also reported in other models of fatigue like keeping the rats in a wet cage and subjecting the rats to a weight-loaded forced swimming test for evaluation of the extent of fatigue (Tanaka et al, 2003). In this paper, increased 5-HT and dopamine turnover in the hippocampus, hypothalamus and in the striatum were shown, suggesting the involvement of hippocampus and hypothalamus in central fatigue (Tanaka et al, 2003). In another microdialysis study, the effects of glucose supplementation before and during exercise on brain glucose and 5-HT were studied in hippocampus of rats, where 5-HT concentration was shown to be a mirror-reflect of cerebral glucose .…”

Section: Discussionmentioning

confidence: 73%

5-hydroxytryptamine release in the anterior hypothalamic and the hippocampal areas of cholestatic rats

et al. 2006

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“…17) In addition, SUN, lactic acid and hepatic glycogen are representative blood biochemical parameters related to fatigue. SUN, the product of energy metabolism when moving, is a sensitive index to evaluate the bearing capability when human bodies suffer from a physical load.…”

Section: Resultsmentioning

confidence: 99%

The Anti-fatigue Effect of 20(R)-Ginsenoside Rg3 in Mice by Intranasally Administration

Tang

Zhang

Gao

et al. 2008

Biological & Pharmaceutical Bulletin

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20(R)-ginsenoside Rg3 (20(R)-Rg3) has shown multiple pharmacological activities and been considered as one of the most promising approaches for fatigue treatment. However, 20(R)-Rg3 has a low bioavailability after oral administration in human due to the first-pass effect. Recently, nasal route has gained increasing interest as it can avoid first-pass effect for its lower enzymatic activity compared with the gastrointestinal tract and liver. In order to provide an animal experimental evidence of 20(R)-Rg3 intranasal administrated preparation, the antifatigue effect of 20(R)-Rg3 after intranasal administration was investigated. Two weeks after 20(R)-ginsenoside Rg3 was administrated intranasally to mice at three different doses, the anti-fatigue effect of 20(R)-Rg3 was evaluated by the weight-loaded swimming test and biochemical parameters related to fatigue, such as serum urea nitrogen (SUN), lactic dehydrogenase (LDH), superoxide dismutase (SOD), malondialdehyde (MDA), blood lactic acid (LA) and hepatic glycogen. The results showed that compared with the negative control group, the intermediate-dose and the high-dose groups significantly prolonged the weight-loaded swimming time (pϽ0.05; pϽ0.01), and also increased the hepatic glycogen levels (pϽ0.05); SUN levels were decreased considerably in three 20(R)-Rg3-treated groups (pϽ0.01). In addition, the low-dose group obviously decreased the content of blood LA (pϽ0.05). However, the levels of LDH, SOD and MDA did not show a significant change. Our results predicted a benefit of 20(R)-Rg3 as an anti-fatigue treatment by intranasal administration. The mechanism was related to the increase of the storage of hepatic glycogen, and the decrease of the accumulation of metabolite such as lactic acid and serum urea nitrogen.

show abstract

Establishment and assessment of a rat model of fatigue

Cited by 120 publications

References 15 publications

Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae Preparata

Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae Preparata

5-hydroxytryptamine release in the anterior hypothalamic and the hippocampal areas of cholestatic rats

The Anti-fatigue Effect of 20(R)-Ginsenoside Rg3 in Mice by Intranasally Administration

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