Essential oils in ocular pathology: an experimental study

Abstract

Introduction: The antimicrobial activity of essential oils (EOs) has been known for ages; in particular, the EOs of Melaleuca alternifolia, Thymus vulgaris, Mentha piperita, and Rosmarinus officinalis have been used for the treatment of fungal and bacterial infections. Methodology: This study focused on the in vitro cytotoxicity to normal human conjunctiva cells and antimicrobial activity of 20 EOs. Results: The oils tested showed no cytotoxic effect at very low concentrations. Rosmarinus officinalis, Melaleuca alternifolia, and Thymus vulgaris L. red thyme geraniol sel oils had good antimicrobial activity against Gram-positive and Gram-negative strains. Conclusions: The results of this study are of great interest and may have a major impact on public health, providing useful tips to optimize the therapeutic use of some natural drugs.

<p>Assessment of Public Awareness, Attitude, and Practice Regarding Antibiotic Resistance in Kemissie Town, Northeast Ethiopia: Community-Based Cross-Sectional Study</p>

“…Concerning the consequences of antibiotic resistance, about 29% of the participants believed they were not cured because of AMR and, hence, 20% of them believed that it is better to shift to other expensive drugs or to natural products available in the local area. The intention of the participants to shift to natural products to treat AMR resistant bacteria can be supported by the findings from the following studies; Essential oils like lavender oil, 27 Rosmarinus officinalis , Melaleuca alternifolia , and Thymus vulgaris , 28 Melaleuca alternifolia , and Thymus vulgaris– red thyme geraniol 29 have been shown to have antibacterial activity against pseudomonas aerogunosa bacteria. A new approach could be using new drugs such as inhibitors of applicable pump.…”

Enhancement of antimicrobial activity of pump inhibitors associating drugs

“…The concentration of each EIs to be used in combination with drugs correspond to ¼ of its MFC or MBC to be devoid antimicrobial activity. Cytotoxicity activity of EIs was assessed on alveolar macrophages [4]. Each experiment was performed in duplicate and repeated three times.…”

Microglial Response to Aspergillus flavus and Candida albicans: Implications in Endophthalmitis

“…Conidia and yeasts have a differential immune response and understanding this and other mechanisms of inflammation will further our ability to initiate strategies of immunomodulation, to minimize the retinal damage associated with endophthalmitis. Thus, this study advances the role using immunomodulators such as natural extracts and essential oils [52][53][54] or phytochemicals in mitigating the impact of inflammatory molecules as some compounds have already been shown to be effective in the treatment of multidrug resistance infections [55]. Similarly, a commercial ophthalmic solution containing PVP-I 0.6% [56] and the more recently approved keratosept, containing hexamidine diisethionate 0.05%, used to aid in a faster re-epithelization, showed rapid antifungal activity against different Candida strains [57], and also represent promising compounds for adjuvant therapy.…”