Essential oils: from prevention to treatment of skin cancer

Pavithra, P; Mehta, Alka; Verma, Rama Shanker

doi:10.1016/j.drudis.2018.11.020

Cited by 33 publications

(18 citation statements)

References 70 publications

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“…Additionally, the study clearly shows that geraniol activates apoptosis in TPA-induced skin cancers, reducing the expression of antiapoptotic Bcl-2 and increasing the expression of proapoptotic Bax protein. [ 79 , 107 , 109 ]…”

Section: Anti-tumor Activity Of Geraniolmentioning

confidence: 99%

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One Hundred Faces of Geraniol

2020

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Geraniol is a monoterpenic alcohol with a pleasant rose-like aroma, known as an important ingredient in many essential oils, and is used commercially as a fragrance compound in cosmetic and household products. However, geraniol has a number of biological activities, such as antioxidant and anti-inflammatory properties. In addition, numerous in vitro and in vivo studies have shown the activity of geraniol against prostate, bowel, liver, kidney and skin cancer. It can induce apoptosis and increase the expression of proapoptotic proteins. The synergy of this with other drugs may further increase the range of chemotherapeutic agents. The antibacterial activity of this compound was also observed on respiratory pathogens, skin and food-derived strains. This review discusses some of the most important uses of geraniol.

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Section: Anti-tumor Activity Of Geraniolmentioning

confidence: 99%

“…Geraniol was also administered to female C57BL mice on a diet (0.65, 6.5 and 65 mmol/kg, respectively) for 14 days before cancer induction and for another 21 days after tumor transplantation. The growth of melanoma was inhibited already at a geraniol dose of 6.5 mmol/kg of food [ 109 , 111 ].…”

Section: Anti-tumor Activity Of Geraniolmentioning

confidence: 99%

One Hundred Faces of Geraniol

2020

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“…Colloids Surf B Biointerfaces 113: 330-7. (2014) Ziani, K., Chang, Y., McLandsborough, L., & McClements, D., In uence of surfactant charge on antimicrobial e cacy of surfactant-stabilized thyme oil nanoemulsions. J Agric Food Chem 59: 6247-55.…”

Section: Con Ict Of Interest Statementmentioning

confidence: 99%

“…In this regard, natural products have been proved as successful resource of potential pharmaceutical agent (Esmail et al 2019). Natural products, especially derived from plants, are found to be effective in cancer chemoprevention and therapy (Pavithra et al 2019) Recently, nanoemulsions (NEs) also have gained a tremendous attention because of their potential in a wide variety of applications including cosmetic, food and pharmaceutical industry applications. NEs are ultra ne oil-in-water suspensions having a droplet size range of 10-600 nm (Solans et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Anticancer activity of food grade nanoemulsions on hepatic cancer cells: a comparative study

Hassan¹,

Khan²

2020

Preprint

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The current study was aimed to prepare stable NEs from plant oils to evaluate their cytotoxic effect on HepG2 cells. Oils form three different samples (flax seeds, cloves and olives) were extracted. NEs from these oils were prepared separately by ultrasonication method. After characterization of stable NEs, they were evaluated for their antioxidant and anticancer activities. Extracted oils and their NEs were applied separately to HepG2 cell line to construct a comparison and MTT assay was used for this purpose. Prepared NEs were found more effective against cancer cell line as compared to their respective oils. MTT assay showed efficacy of NEs in reducing cell viability with IC50 value of 10 µl (flax seed oil), 25 µl (clove oil NE) and 1 µl (olive oil NE), and was safe to normal cells. The results of the current study revealed that NEs prepared from flax seed, clove and olive oil have the potential for further development as anticancer agents.

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“…These compounds have a lipophilic character and low molecular weight, therefore they can penetrate cell membranes, leading to a decrease in ATP production and loss of mitochondrial potential. These changes may lead to cancer cell death [1][2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

An Advanced Mode of Antioxidants Delivery System Effective in the Treatment of ROS and Skin Permeation of The Cosmetic Formulations - The Possible Application of Clove Oil, Eugenol and New Eugenol Derivative

Makuch¹,

Nowak²,

Günther³

et al. 2020

Preprint

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The main focus of this work is to extend the knowledge about the complexity of issues of oxidative stress. Natural compounds play a serious role in multiple aspects of both human, leading to clear health-promoting effects. This work is focused on the potential application cosmetic formulations containing including but not limited to of clove water and isolated clove oils on their aid in the control of the diseases. The aim of our work was to prepare to evaluate cosmetic formulations containing clove oil, eugenol or new eugenol ester derivative (eugenyl dichloroacetate - EDChA) but also cosmetic formulations containing the aqueous phase obtained after separation of essential oil following the clove buds steam distillation. To evaluate the antioxidants transdermal delivery system, in vitro permeation experiments in a Franz diffusion cell were performed using pig skin. The antioxidative capacity of the cosmetic formulations obtained was determined by the DPPH free radical reduction method. In the next stage, the antioxidant activity (DPPH, ABTS, and Folin–Ciocalteu methods) of the fluid that penetrated through pig skin and of the fluid obtained after skin extraction, were also evaluated. For comparison, studies of cosmetic formulation containing alone dichloroacetic acid (DChAA) were as well carried out. The obtained cosmetic formulations were characterized by of antioxidant activity estimated after 24 hours of conducting the experiment, which indicates long-term protection against reactive oxygen species (ROS) in the deeper layers of the skin. The results of this work contribute to the development of cosmetic formulations with antioxidant potential, emphasizing that the water phases are waste from the process of cloves steam distillation and are not used to prepare cosmetic formulations. The use of waste water from the clove buds steam distillation process is environmentally friendly and not allows us to waste, containing however valuable biologically active compounds (furfural, methyl salicylate, 4-allilofenol, eugenol, α- and β-caryophyllene, eugenyl acetate, β-caryophyllene oxide). Together, these results suggest that cosmetic formulations may be potential drug candidates for chemopreventive, antineoplastic and antimutagenic therapy.

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Essential oils: from prevention to treatment of skin cancer

Cited by 33 publications

References 70 publications

One Hundred Faces of Geraniol

One Hundred Faces of Geraniol

Anticancer activity of food grade nanoemulsions on hepatic cancer cells: a comparative study

An Advanced Mode of Antioxidants Delivery System Effective in the Treatment of ROS and Skin Permeation of The Cosmetic Formulations - The Possible Application of Clove Oil, Eugenol and New Eugenol Derivative

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