One Hundred Faces of Geraniol

Mączka, Wanda; Wińska, Katarzyna; Grabarczyk, Małgorzata

doi:10.3390/molecules25143303

Cited by 96 publications

(66 citation statements)

References 117 publications

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“…Administration of coffee polyphenol extract significantly increases GLP-1 secretion in NCI-H716 and C57BL/6J mice associated with increasing intracellular cAMP levels in a dose-dependent manner [ 69 ]. Geraniol, an acyclic mnonoterpene alcohol extracted from the ethereal oils of aromatic plants, and citronellal, a specialized metabolite of plants found in Cymbopogon spp ., have a number of biological activities, such as antioxidant and antidiabetic properties [ 78 ]. Kim et al found that geraniol- and citronellal-stimulated GLP-1 secretion in NCI-H716 cells are mediated by the activation of olfactory receptor 1G1, the activation of Adcy, increased intracellular cAMP levels, and extracellular calcium influx.…”

Section: Gutmentioning

confidence: 99%

Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

Wang

Liu²,

Kang

et al. 2021

Nutrients

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As the prevalence of diabetes increases progressively, research to develop new therapeutic approaches and the search for more bioactive compounds are attracting more attention. Over the past decades, studies have suggested that cyclic adenosine monophosphate (cAMP), the important intracellular second messenger, is a key regulator of metabolism and glucose homeostasis in diverse physiopathological states in multiple organs including the pancreas, liver, gut, skeletal muscle, adipose tissues, brain, and kidney. The multiple characteristics of dietary compounds and their favorable influence on diabetes pathogenesis, as well as their intersections with the cAMP signaling pathway, indicate that these compounds have a beneficial effect on the regulation of glucose homeostasis. In this review, we outline the current understanding of the diverse functions of cAMP in different organs involved in glucose homeostasis and show that a diversity of bioactive ingredients from foods activate or inhibit cAMP signaling, resulting in the improvement of the diabetic pathophysiological process. It aims to highlight the diabetes-preventative or -therapeutic potential of dietary bioactive ingredients targeting cAMP signaling.

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Section: Gutmentioning

confidence: 99%

Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

Wang

Liu²,

Kang

et al. 2021

Nutrients

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“…Many studies have shown the antitumor activity of monoterpenes in cancer cells in vitro and in vivo through promoting cell cycle arrest, apoptosis, autophagy, and/or senescence [ 15 , 16 , 17 , 18 ]. The main anticancer mechanisms reported for these natural compounds include the inhibition of proteins involved in cell survival and proliferation (Ras, ERK, Akt), modulation of oxidative stress and endoplasmic reticulum stress, and depolarization of mitochondrial membrane potential [ 18 , 19 , 20 ]. In addition, it was reported increased anticancer activity of antineoplastic drugs combined with monoterpenes, suggesting their potential as novel anticancer molecules also employed as sensitizer compounds [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells

Rodenak-Kladniew

Castro

Crespo

et al. 2020

Heliyon

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Linalool and 1,8-cineole are plant-derived isoprenoids with anticancer activities in lung cancer cells, nevertheless, the cellular and molecular mechanisms of action remain poorly understood. The purpose of this study was to determine the anticancer mechanisms of action of linalool and 1,8-cineole in lung adenocarcinoma A549 cells. Linalool (0–2.0 mM) and 1,8-cineole (0–8.0 mM) inhibited cell proliferation by inducing G0/G1 and/or G2/M cell cycle arrest without affecting cell viability of normal lung WI-38 cells. None of the two monoterpenes were able to induce apoptosis, as observed by the lack of caspase-3 and caspase-9 activation, PARP cleavage, and DNA fragmentation. Linalool, but not 1,8-cineole, increased reactive oxygen species production and mitochondrial membrane potential depolarization. Reactive oxygen species were involved in cell growth inhibition and mitochondrial depolarization induced by linalool since the antioxidant N-acetyl-L-cysteine prevented both effects. Besides, linalool (2.0 mM) and 1,8-cineole (8.0 mM) inhibited A549 cell migration. The combination of each monoterpene with simvastatin increased the G0/G1 cell cycle arrest and sensitized cells to apoptosis compared with simvastatin alone. Our results showed that both monoterpenes might be promising anticancer agents with antiproliferative, anti-metastatic, and sensitizer properties for lung cancer therapy.

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“…Several studies have been conducted to gain insights into its anti-cancer activity [112][113][114]. Ornithine decarboxylase (ODC) plays a prime role in the synthesis of polyamines, providing stabilization to DNA structure [132]. A decrease in ODC activity after geraniol treatment has been observed in the intestinal adenocarcinoma Caco-2 cell line, which, in turn, caused DNA synthesis inhibition and cell cycle arrest in the S phase [132].…”

Section: Anticancer Activitymentioning

confidence: 99%

“…Ornithine decarboxylase (ODC) plays a prime role in the synthesis of polyamines, providing stabilization to DNA structure [132]. A decrease in ODC activity after geraniol treatment has been observed in the intestinal adenocarcinoma Caco-2 cell line, which, in turn, caused DNA synthesis inhibition and cell cycle arrest in the S phase [132]. Polyamine metabolism is a potential target in the development of cancer-preventive drugs, therefore, geraniol mediated decline in ODC activity might have a useful clinical role [133].…”

Section: Anticancer Activitymentioning

confidence: 99%

Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

Mukarram¹,

Choudhary²,

Khan³

et al. 2021

Preprint

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The prominent cultivation of lemongrass relies on the pharmacological incentives of its essential oil. The lemongrass essential oil (LEO) has a significant amount of citral (mixture of geranial and neral), isoneral, isogeranial, geraniol, geranyl acetate, citronellal, citronellol, germacrene-D, and elemol in addition to numerous other bioactive compounds. These components confer various medicinal activities to LEO including antifungal, antibacterial, antiviral, anticancer, and antioxidant properties. These attributes are commercially exploited in pharmaceutical, cosmetics, and food preservations industries. Furthermore, the employment of LEO in the treatment of cancer opens a new vista in the field of therapeutics. Although different LEO components have shown promising anticancer activities in vitro, these effects have not been assessed yet in humans. Further studies on the anticancer mechanisms exerted by lemongrass components are required. The present review intends to provide a timely discussion on the relevance of lemongrass extracts in cancer and health treatment, and in food industry applications.

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One Hundred Faces of Geraniol

Cited by 96 publications

References 117 publications

Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells

Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

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