Essential Oil of &lt;i&gt;Otostegia integrifolia&lt;/i&gt; Benth: Composition, Antimicrobial and Antioxidant Activities

Tadesse, Solomon; Messele, Bruck; Seyoum, Ameha; Mazumder, Avijit; Bučar, Franz; Asres, Kaleab

doi:10.4314/epj.v29i2.1

Cited by 4 publications

(8 citation statements)

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“…In Ethiopia, O.integrifolia has been used traditionally for treatment of DM by the community documented in literatures [ 11 , 20 ] without any scientific proof for safety and efficacy. Althoug there is no previous investigation conducted in animals; several studies suggest that O. integrifolia is a good natural anti-oxidant that can be used as health-promoting agent for various disorders including DM [ 21 ]. The fact that hyperglycemia can be induced by generation of free radicals leading to the disruption of cellular functions, anti-oxidant agents are options in management of chronic disease like DM [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Methanolic leaf exctract of Otostegia integrifolia Benth reduces blood glucose levels in diabetic, glucose loaded and normal rodents

Shewamene

Abdelwuhab

Birhanu

2015

BMC Complement Altern Med

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BackgroundAlthough the leaves of Otostegia integrifolia traditionally claimed in Ethiopian folklore medicine for management of diabetes mellitus, it has not been validated. The aim of this study was therefore to investigate the antidiabetic activity of Otostegia integrifolia in rodents.MethodsMale rats or mice were randomly divided into five groups for diabetic, hypoglycemic and glucose tolerance test (OGTT) studies. In all models, group I received Tween 80, 2% v/v, Group II (GL5) treated with 5 mg/kg of glibenclamide and the remaining group: III, IV and V were given the plant extract at doses of 100 mg/kg 200 mg/kg and 400 mg/kg respectively. Blood glucose levels (BGL) were measured by collecting blood samples at different time points. Data was analyzed using one way ANOVA followed by Dunnet’s post hoc test to carry out between and within group comparisons. P < 0.05 was considered as statistically significant.ResultsInter-group analysis revealed that O. integrifolia at 100 mg/kg and 200 mg/kg reduced the 4th hour fasting blood BGL significantly (p < 0.001) compared to the control group. The intra-group analysis result has shown O. integrifolia at 200 mg/kg produced a significant (p < 0.05) reduction in BGL at the 1st, 2nd, 3rd and 4th hours of post treatment compared to their respective initial levels. Moreover, in the hypoglycemic and OGTT models, O. integrifolia extract at 200 mg/kg, has shown a significant reduction in blood glucose levels compared to negative controls and across all time points.ConclusionThe crude extract of O. integrifolia has shown significant antidiabetic, hypoglyceamic and oral glucose tolerating effects. The effective dose of the extract was found to be 200 mg/kg in time dependent manner.

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Section: Introductionmentioning

confidence: 99%

Methanolic leaf exctract of Otostegia integrifolia Benth reduces blood glucose levels in diabetic, glucose loaded and normal rodents

Shewamene

Abdelwuhab

Birhanu

2015

BMC Complement Altern Med

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“…In fact, the O. michauxii from southern Zagros of Iran show caryophyllene oxide as a main compound [225], whereas the one collected in the Fars province of Iran had an equal amount of monoterpenes and sesquiterpenes [226]. In O. integrifolia, the monoterpene α-pinene occurs in 31 % of the oil [56], whereas in some collections of O. persica, in several places of southeast Iran, a clear trend cannot be observed.…”

Section: Nomentioning

confidence: 95%

“…The inhibition activity was higher for the latter enzyme (IC 50 22.3, 17.5 and 14.2 µM, respectively) than for the former (IC 50 38.5, 47.2, and 103.7 µM) [112]. These enzymatic systems were also the targets of another similar work concerning the isolation of 6 clerodane tricyclic diterpenes from the chloroform extract of B. limbata [107]: ballatenolide A (59), 15-methoxypatagonic acid (71), patagonic acid (72), and limbatenolides A-C (54)(55)(56). All of the compounds showed inhibitory activity with BChE with IC 50 values ranging from 24.9 to 51.0 µM, lower than the standard inhibitor galanthamine (8.5 µM).…”

Section: Enzymatic Activity Modulationmentioning

confidence: 95%

“…In northern Ethiopia, it is commonly used to smoke utensils for sterilization. It is also a ritual custom for a mother to cleanse herself with the smoke on the tenth day after giving birth to a child before leaving her confinement to resume normal daily activities [56]. It has been largely employed as an insect repellent against fleas and mosquitos and as antimalarial [47,50,52,53].…”

Section: Traditional Usesmentioning

confidence: 99%

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A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia

2019

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The genus Ballota, belonging to Lamiaceae family (Stachyoideae/ Lamioideae subfamily) [1,2], is, apart from the South African endemic species Ballota africana (L.) Benth., naturally distributed in the Mediterranean, the Middle East and in North Africa. Some species (e.g., Ballota nigra L. s. l.) are also present over large areas of western, central, and northern Europe, and 4 species, whose status will be discussed later, in Somalia.Ballota species are perennial herbs or small shrubs with branched and/or simple hairs, toothed and petiolate leaves, the inflorescence thyrsoid or racemoid sometimes has long and spinose bracteoles (sect. Acanthoprasium), and the calyx is mostly campanulate, purple to white.A former classification of the genus identified the occurrence of 31 species (1 = Ballota integrifolia Benth. -2 = Ballota wettsteinii Rech. pat. -3 = Ballota frutescens (L.) Woods -4 = Ballota fruticosa Baker -5 = Ballota somala Patzak -6. Ballota andreuzziana Pamp. -7 = Ballota acetabulosa (L.) Benth. -8 = Ballota undulata (Sieb, ex Fres.) Benth. -9 = Ballota pseudodictamnus (L.) Benth. -10 = Ballota damascena Boiss. -11 = Ballota hildebrandtii Vatke et Kurtz -12 = Ballota hirsuta Benth. -13 = Ballota bullata Pomel -14 = B. africana (L.) Benth. -15 = Ballota aucheri Boiss. -16 = Ballota macrodonta Boiss. et Bal. -17 = Ballota larendana Boiss. et Heldr. -18 = Ballota rotundifolia C. Koch -19 = Ballota rupestris (Biv.) Vis. -20 = Ballota macedonica Vand. -21 = Ballota kaiseri V. Täckh. -22 = Ballota antilibanotica Post -23 = Ballota cristata Davis -24 = Ballota semanica Rech. f. -25 = Ballota labillardieri Briq. -26 = Ballota saxatilis Sieb. ex J. et C. Presl -27 = Ballota stachydiformis Höchst. -28 = Ballota philistea Bomm. -29 = Ballota platylomaThe 2 genera Ballota and Otostegia, belonging to the Lamiaceae family, are closely related taxonomically and found mainly in the Mediterranean area, Middle East, and North Africa. Since ancient times, they have been largely employed in traditional medicine for their biological properties such as antimicrobial, anti-inflammatory, antispasmodic, insecticidal, anti-malaria, etc. Phytochemical investigations of Ballota and Otostegia species have revealed that diterpenoids are the main constituents of the genera. A large number of flavonoids and other metabolites were also identified. This review, covering literature from 1911 up to 2018, includes traditional uses, chemical profiles (both of volatile and nonvolatile metabolites), and biological properties of all the taxa of these 2 genera studied to date.

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“…[14][15][16] Other reports indicated that the leaves of the plant are used for tonsillitis, uvulitis, lung diseases, stomachache, malaria, and hypertension. 12,[17][18][19] Upon pharmacological investigation, O. integrifolia exhibited antibacterial, antioxidant, 20,21 antidiabetic, 22 and antimalarial activities. 13 It consists of terpenes in the form of monoterpenes, sesquiterpenes, and diterpenes.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Analgesic and Anti-inflammatory Potential of 80% Methanol Leaf Extract of Otostegia integrifolia Benth (Lamiaceae)

Degu

Abebe

et al. 2020

JIR

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Introduction Pain and inflammatory disorders are the most prevalent syndromes. Different herbs were used for treatment of pain and inflammation including members of the genus Otostegia . As a result, this research investigated the in vivo analgesic and anti-inflammatory effects of 80% methanol leaf extract of Otostegia integrifolia in mice. Methods The analgesic and anti-inflammatory effects of the plant was evaluated using hot plate method, acetic-acid induced writhing test, and carrageenan and formalin induced paw edema. Three experimental groups (100, 200, and 400 mg/kg) received the extract while morphine 10 mg/kg and aspirin 150 mg/kg were used as a positive control for analgesic and anti-inflammatory tests accordingly. Distilled water (10 mL/kg) was used as negative control. Results From the experimental groups, OI400 displayed significant analgesic and anti-inflammatory activities ( P <0.001). In acetic acid induced writhing tests, the number of writhes decreased significantly ( P <0.001) in all experimental groups. Similarly, OI400 reduced the mean paw edema significantly in carrageenan and formalin induced paw edema ( P <0.05 and P <0.001, respectively). Conclusion In general, the results obtained in this study demonstrated that the extract exhibited significant analgesic and anti-inflammatory potential in mice.

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Essential Oil of <i>Otostegia integrifolia</i> Benth: Composition, Antimicrobial and Antioxidant Activities

Cited by 4 publications

References 7 publications

Methanolic leaf exctract of Otostegia integrifolia Benth reduces blood glucose levels in diabetic, glucose loaded and normal rodents

Methanolic leaf exctract of Otostegia integrifolia Benth reduces blood glucose levels in diabetic, glucose loaded and normal rodents

A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia

Evaluation of Analgesic and Anti-inflammatory Potential of 80% Methanol Leaf Extract of Otostegia integrifolia Benth (Lamiaceae)

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