Essential oil ofPsidium cattleianumleaves: Antioxidant and antifungal activity

Abstract

Context: Psidium cattleianum Sabine (Myrtacea) is rich in vitamin C and phenolic compounds, including epicatechin and gallic acid as the main components. Objective: To evaluate the antifungal and antioxidant capacity in vitro of the essential oil of araçá (EOA). The acute toxicity of the EOA also was evaluated in mice. Materials and methods: The leaves of the P. cattleianum were extracted by steam distillation. The antioxidant capacity was evaluated by in vitro tests [1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric ion reducing antioxidant power (FRAP), linoleic acid oxidation, thiobarbituric acid reactive species (TBARS)], and ex vivo analysis [TBARS, d-aminulevunilate dehydratase (d-Ala-D) and catalase activity, non-protein thiols (NPSH), and ascorbic acid levels]. The toxicity was studied in mice by a single oral administration of EOA; and the antifungal activity was performed with five strains of fungi. Results: The EOA exhibited antioxidant activity in the FRAP assay and reduced lipid peroxidation in the cortex (I max ¼ 32.90 ± 2.62%), hippocampus (IC 50 ¼ 48.00 ± 3.00 mg/ml and I max ¼ 32.90 ± 2.62%), and cerebellum (I max ¼ 45.40 ± 14.04%) of mice. Acute administration of the EOA by the oral route did not cause toxicological effects in mice (LD 50 4500 mg/ml). The EOA also showed antifungal activity through of the determination minimum inhibitory concentration (MIC) values ranging from 41.67 ± 18.04 to 166.70 ± 72.17 mg/ml for tested strains. Conclusion:The results of present study indicate that EOA possess antioxidant properties, antifungal and not cause toxicity at tested doses.

Effect of seasonality on chemical profile and antifungal activity of essential oil isolated from leaves Psidium salutare (Kunth) O. Berg

“…(2016b) observed fluconazole and all extracts had high inhibitor concentrations, however, when these were in association with sub-inhibitory concentrations (MIC/16), fluconazole had an improved effect, thus a synergistic effect was observed in the combination of fluconazole with extracts of Psidium brownianum against all strains of Candida ( Morais-Braga et al, 2016b ). According to this study, Castro et al (2015) demonstrated that the P. cattleianum essential oil had an effect on the inhibition of important clinical fungal strains such as Trichosporon asahii ( Castro et al, 2015 ), C. parapsilosis , C. albicans , C. lipolytica and C. guilhermondi , with concentrations ranging from 41.67 ± 18.04 to 16,670 ± 72.17 µg/mL for the tested strains.…”

Atividade antifúngica in vitro dos óleos essenciais Eugenia uniflora e Psidium cattleianum contra o fitopatógeno Thielaviopsis basicola.

“…A concentração de 0,1% não apresentou inibição significativa (FIGURA 2). Em estudos anteriores, foi possível verificar que os óleos essenciais de E. uniflora e P. cattleianum demonstraram atividade antifúngica (CASTRO et al, 2015). Santos (2016) comparou os óleos essenciais de cinco espécies da família Myrtaceae (Pitanga, Goiaba, Grumixama, Jamelão e Araçá) para atividade antifúngica, utilizando o fungo patógeno Fusarium oxysporum.…”

Avaliação da atividade antimicrobiana de extratos de Eugenia anomala e Psidium salutare (Myrtaceae) frente à Escherichia coli e Listeria monocytogenes

“…Pode-se observar que a AA% dos extratos etanólico e de acetato de etila em ambas as espécies vegetais foi maior, onde houve aumento nesta atividade de acordo com o aumento da concentração do extrato analisado, sendo que na maior concentração analisada de 50 µg/mL o extrato (Braga et al, 2014;Castro et al, 2014;Fernandes et al, 2014;Moreno et al, 2014;Seo et al, 2014;Thakur & Arya, 2014).…”