Essential Oil of<i>Haplophyllum tuberculatum</i>(Forssk.) A. Juss. from the United Arab Emirates

Yousuf, Maryam H. Al; Bashir, A. K.; Veres, Katalin; Dobos, Ágnes; Nagy, Gábor; Máthé, Imre; Blunden, Gerald; Vera, Janne Rojas

doi:10.1080/10412905.2005.9698981

Cited by 20 publications

(14 citation statements)

References 3 publications

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“…The essential oil from the species growing in Oman contained, as its major components, βphellandrene (23.3%), limonene (12.6%), β-ocimene (12.3%), βcaryophyllene (11.6%), myrcene (11.3%), and α-phellandrene (10.9%) [14]. On the other hand, the composition of the essential oils from the United Arab Emirates collected in May during 1997 and 2001, contained predominantly β-caryophyllene (6.3-12.8%), β-pinene (7.6-8.0%), limonene (4.0-9.6%) and delta-3-carene (5.5-6.0%), whereas those plants collected in April (1998) contained high amounts of linalool (15.0%), linalyl acetate (10.6%), βcaryophyllene (9.7%) and α-terpineol (6.7%) [15]. Comparing the composition of the essential oils of H. tuberculatum from our study with those previously reported, the investigated ecotype is closest to the Iranian one.…”

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confidence: 99%

Compositional Analysis and in vitro Protective Activity against Oxidative Stress of Essential Oils from Egyptian Plants Used in Traditional Medicine

Eissa

González-Burgos

Carretero

et al. 2014

Natural Product Communications

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The Sinai desert in Egypt contains great variability in plants extensively used for traditional medicines such as Achillea fragrantissima, Chiliadenus montanus, Mentha longifolia and Haplophyllum tuberculatum. The essential oils extracted by hydrodistillation from the aerial parts have been analyzed. Subsequently, their potential protective activity against oxidative stress has been evaluated, employing H 2 O 2 as oxidant inductor and astrocytes as the cell model. The chemical composition of the essential oils was analyzed by GC/MS. Most of the compounds identified in A. fragrantissima and M. longifolia samples were oxygenated monoterpene derivatives, whereas for H. tuberculatum they were monoterpenes hydrocarbons and oxygenated compounds, and for C. montanus oxygenated monoterpenes and oxygenated sesquiterpenes predominated. The in vitro evaluation of antioxidant properties, using ORAC assay, revealed that M. longifolia essential oil possessed the highest scavenging activity against peroxyl radicals, following by H. tuberculatum, A. fragrantissima and C. montanus. Under oxidative stress conditions, M. longifolia and H. tuberculatum essential oils were the only ones that protected human astrocytoma U373-MG cells against H 2 O 2 damage. Both essential oils prevented cell death and inhibited ROS production caused by H 2 O 2. M. longifolia essential oil was the most active, suggesting an interesting prevention role in those CNS disorders associated with oxidative stress.

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confidence: 99%

Compositional Analysis and in vitro Protective Activity against Oxidative Stress of Essential Oils from Egyptian Plants Used in Traditional Medicine

Eissa

González-Burgos

Carretero

et al. 2014

Natural Product Communications

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“…Literature review showed variation between chemical compositions, depending on the location and stages of development of H. tuberculatum . Reports from Oman [ 19 ], Iran [ 33 ] and the United Arab Emirates [ 34 ] showed a difference between the major compounds. The comparison of the chemical composition from the different parts of our H. tuberculatum with that of H. tuberculatum from Oman showed that the main compounds varied [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…The analysis of the aerial parts of H. tuberculatum collected in May 1997 and 2001 from the United Arab Emirates showed that the major compounds were α-phellandrene (10.7–32.9%), β-caryophyllene (6.3–12.8%), β-pinene (7.6–8.0%), limonene (4.0–9.6%) and δ-3-carene (5.5–6.0%). However, the oil distilled from plants collected in April (1998) had as major components linalool (15.0%), linalyl acetate (10.6%), β-caryophyllene (9.7%) and α-terpineol (6.7%) [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

In vitro antileishmanial and cytotoxicity activities of essential oils from Haplophyllum tuberculatum A. Juss leaves, stems and aerial parts

Hamdi

Béro

Beaufay

et al. 2018

BMC Complement Altern Med

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BackgroundPlants used for traditional medicine produce diverse and complex secondary metabolites exhibiting various medicinal properties. The medicinal plant Haplophyllum tuberculatum is used by native people against malaria and parasitic infections.MethodsIn this study and in order to contribute for the search of new natural drugs for leishmaniasis, the essential oils of H. tuberculatum leaves, stems and aerial parts (leaves+stems) collected in two different periods, 2013 and 2015, and their components by GC/FID and GC/MS analyses were investigated. Those collected in 2013 were also re-analyzed two years later. The extracted oils were screened in vitro for anti-leishmanial activity on Leishmania mexicana mexicana (L.m.m.) promastigotes and cytotoxicity on the Chinese Hamster Ovary (CHO) cell line. Limonene (1.5 – 8%), its isomers (R- (+)-limonene and S-(-)-limonene), linalool and octanol were also tested.ResultsResults showed that the chemical composition varied according to the year of collection. Though major compounds remain almost the same, qualitative and quantitative variations in the composition of the EOs can be observed between the two years of collection, with some minor compounds identified only in one type of samples. Variation in the composition were also observed in the re-analyzed volatile oils, showing stability concerns. The essential oils and R-(+)-limonene showed moderate anti-leishmanial activity. Their IC50 range from 6.48 to 50.28 μg/ml. Cytotoxicity assays for theses volatile extracts, R- (+)-limonene and S- (-)-limonene on CHO cells showed relatively potent cytotoxicity with a selectivity index <10. Their CC50 range from 27.79 to 82.56 μg/ml.ConclusionsThe findings of the present study demonstrated that H. tuberculatum might not be considered as a natural source for production of new anti-leishmanial agents without further analyzing its eventual in vivo toxicity as well as that of major pure compounds.

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“…γ-terpinen, the major component of the oil in the present work (26-38%) was detected only in trace amounts in the essential oil obtained from H. tuberculatum in other countries. [17][18][19] On the contrary, limonene (absent in the Libyan sample), linalool, and beta caryophyllene, were present in major quantities (12.8 %, 15.5% and 12.77% ) in the essential oil of the H. tuberculatum of Iran, United Arab Emirates, Oman and Iran respectively. [17][18][19] Moreover, the hydrocarbons, β-phellandrene, α-pinene, and 3-carene were present in Libyan and Egyptian samples in comparable amounts.…”

Section: Determination Of Median Lethal Dose Ld 50mentioning

confidence: 90%

“…[17][18][19] On the contrary, limonene (absent in the Libyan sample), linalool, and beta caryophyllene, were present in major quantities (12.8 %, 15.5% and 12.77% ) in the essential oil of the H. tuberculatum of Iran, United Arab Emirates, Oman and Iran respectively. [17][18][19] Moreover, the hydrocarbons, β-phellandrene, α-pinene, and 3-carene were present in Libyan and Egyptian samples in comparable amounts. The difference in oil yield obtained and the composition of essential oil in plants were affected by genetical and environmental conditions, which is determined by growth region and harvesting time in terms of onto genetical and diurnal variability.…”

Section: Determination Of Median Lethal Dose Ld 50mentioning

confidence: 90%

GC/MS Analysis and Potential Cytotoxic Activity of Haplophyllum tuberculatum Essential Oils Against Lung and Liver Cancer Cells

Sabry¹,

Sayed²,

Alshalmani³

2015

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Background: Haplophyllum tuberculatum is a plant belongs to family rutacee. It is rich in volatile oils, fixed oils, alkaloids, and furanocoumarins. It is well known for the huge number of folkloric uses in middle east. Objective: The aim of this study is to establish the chemical composition of the essential oils of Libyan H. tuberculatum and to investigate their cytotoxic potentialities.Materials and Methods: The essential oils of the aerial parts and flowers of H. tuberculatum growing in Libya were prepared by hydrodistillation. GC/MS analyses were performed on a Shimaduz capillary gas chromatograph (GC 17A ver.3) instrument directly coupled to mass spectrometer-MS QP5050A. Oil A and F of H. tuberculatum at different concentrations (0-50 µg/ml) in DMSO were tested for cytotoxicity against human tumor cell lines. Results: Oil yield was found 0.4 and 1.5 (v/w %) on dry weight basis respectively. GC/MS analysis resulted in identification of total 35 compounds. 15 compounds were common to both oils. oil A of H. tuberculatum exhibited antitumor activities against. liver carcinoma

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Essential Oil ofHaplophyllum tuberculatum(Forssk.) A. Juss. from the United Arab Emirates

Cited by 20 publications

References 3 publications

Compositional Analysis and in vitro Protective Activity against Oxidative Stress of Essential Oils from Egyptian Plants Used in Traditional Medicine

Compositional Analysis and in vitro Protective Activity against Oxidative Stress of Essential Oils from Egyptian Plants Used in Traditional Medicine

In vitro antileishmanial and cytotoxicity activities of essential oils from Haplophyllum tuberculatum A. Juss leaves, stems and aerial parts

GC/MS Analysis and Potential Cytotoxic Activity of Haplophyllum tuberculatum Essential Oils Against Lung and Liver Cancer Cells

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