Essential Oil of Garlic in Prevention of Atherosclerosis

Bordia, A; Bansal, Hina

doi:10.1016/s0140-6736(73)92750-5

Cited by 49 publications

(11 citation statements)

References 2 publications

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“…15 Garlic has been shown to have several effects in the body. This includes inhibition of platelet aggregation 16 , and prevention of fat infiltration of the liver.…”

Section: Introductionmentioning

confidence: 99%

To study the hypotensive and hypolipidemic effects of garlic in smokers in the North Indian population

Sanagapati

Vujhini

2015

Int J Res Med Sci

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“…15 Garlic has been shown to have several effects in the body. This includes inhibition of platelet aggregation 16 , and prevention of fat infiltration of the liver.…”

Section: Introductionmentioning

confidence: 99%

To study the hypotensive and hypolipidemic effects of garlic in smokers in the North Indian population

Sanagapati

Vujhini

2015

Int J Res Med Sci

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“…Many investigators have demonstrated various medical effects of garlic (Allium sativum) on the treatment or prevention of many diseases, such as hypertension (1), arteriosclerosis (2,3), heart disease (4), inflammation (5), diabetes (6,7), fungal infections (8), and cancers.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of experimental carcinogenesis by painting with garlic extract

Meng

Shyu

1990

Nutrition and Cancer

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The inhibitory effect of topical garlic extract on 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in Syrian hamsters was studied to define the local anticarcinogenicity of garlic. Two other chemicals, benzo[a]pyrene (BP) and 5-nitroso-2,4,6-triaminopyrimidine (NTP), were also testing materials. All chemicals were applied topically to the cheek pouches of hamsters. The tumorigenesis and architecture of blood vessels on pouch mucosa were examined periodically. The amount of DNA synthesis and gamma-glutamyl transpeptidase activity of the pouch mucosa was detected when the animals were killed. The anticarcinogenicity of garlic and other chemicals was determined by comparing the data obtained from all the examinations with each other and with those shown in the control animals. The apparent local inhibitory effect of garlic on DMBA-induced carcinogenesis was demonstrated, which was even stronger than those of BP and NTP. It suggests that garlic could be developed as a potential chemopreventive agent for oral cancer. This study also disclosed that the examination parameters used were reliable and reproducible. Therefore, they might be utilized for screening the anticarcinogenicity of materials or for early diagnosis of carcinogenesis. The animal model could also be adopted appropriately in evaluating the inhibitory effect of other materials on experimental carcinogenesis because of its comparability.

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“…마늘은 특유의 냄새와 독특한 맛으로 인하여 예로부터 향신 료와 민간약으로 널리 사용되어 왔으며 최근 들어 높은 사망 률을 나타내는 여러 종류의 암 [1,9]이나 고혈압 [8], 동맥경화 [6], 혈중지질 및 콜레스테롤 저하효과 [3,4,37], 항혈전 [18]의 예 방과 치료에 효능이 있다고 알려지면서 많은 연구가 진행되고 있다. 마늘의 유효성분인 allicin은 마늘 특유의 휘발성 향기 성분으로 마늘조직이 파괴될 때 allinase에 의하여 생성되며 allicin이 분해되면 diallyl sulfide, diallyl disulfide, dithiin, ajoene 등의 휘발성 성분과 S-allylcysteine (SAC), S-allylmercaptocysteine 등의 수용성 유황화합물로 분해되어 효능을 나 타낸다 [23].…”

Section: 서 론unclassified

Effects of Aged Black Garlic Extract on Lipid Improvement in Rats Fed with High Fat-Cholesterol Diet

이현숙¹,

양승택²,

류병호³

2011

Journal of Life Science

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This study was performed to investigate the increase of S-allylcysteine content, a biomarker of black garlic, during its aging period, as well as the serum lipid-lowering effects of black garlic extract in high fat diet fed rats. The highest content of S-allylcysteine was observed on the 15th day of the aging period. Sensory evaluation was also estimated to be extremely good on the 15th day of the aging period. High fat diet rats with induced hyperlipidemia were fed diets containing black garlic extract of low, medium, and high doses for 6 weeks. No significant difference in body weight gain and food efficiency was observed between normal, placebo and black garlic fed groups. Liver weight was significantly higher in black garlic fed groups than in the normal group. Total serum cholesterol and triglyceride were significantly lower in low, medium, and high dose groups than in the normal group. Also, HDL-cholesterol was significantly higher and LDL-cholesterol was significantly lower in black garlic diet fed groups than in the normal group. Hepatic levels including total lipid and cholesterol were especially decreased in the black garlic diet fed group than in the placebo group. These results suggest that black garlic intake reduces the levels of serum and hepatic cholesterol in high fat diet fed rats. In conclusion, black garlic has a potential to be used as a functional health food ingredient with beneficial effects on lowering cholesterol and triglyceride levels.

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Essential Oil of Garlic in Prevention of Atherosclerosis

Cited by 49 publications

References 2 publications

To study the hypotensive and hypolipidemic effects of garlic in smokers in the North Indian population

To study the hypotensive and hypolipidemic effects of garlic in smokers in the North Indian population

Inhibition of experimental carcinogenesis by painting with garlic extract

Effects of Aged Black Garlic Extract on Lipid Improvement in Rats Fed with High Fat-Cholesterol Diet

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