To study the hypotensive and hypolipidemic effects of garlic in smokers in the North Indian population

Sanagapati, Pandu Rangarao; Vujhini, Sudhir Kumar

doi:10.18203/2320-6012.ijrms20150326

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…The results showed that treatment with garlic tincture alone were able to modulate lipid peroxidation as evident by the significant decreased in malondialdehyde (MDA), and mark improved level of superoxide dismutase (SOD) and total antioxidant capacity (TAC) which although were not statistically significant at p<0.05 level of significance. This finding is consistent with that recorded by [18] Numair [17], who reported that garlic is capable of reducing lipid peroxidation and improve antioxidant status. The reason for the variation may due to the difference in duration of treatment.…”

Section: Discussionsupporting

confidence: 93%

“…Garlic is proven to have beneficial effects for the prevention of cardiovascular diseases. Several studies have also shown that garlic contains active hypolipidemic components, known as diallyl disulfide and dipropyl disulfide [28,18]. Amagase et al, [29,27], also stated that allicin and other garlic compounds have hypocholesterolemic, hypolipidemic and antihypertensive activity.…”

Section: Discussionmentioning

confidence: 99%

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Synergistic Effect of Coconut Water and Garlic Tincture on Lipids and Oxidative Profile of Albino Rats Treated with High Fat Diet and Alcohol

Brown

Tamuno-Emine

Sweeten

2021

AJBGMB

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Aim: This study evaluated the combined effect of coconut water and garlic tincture on lipid and antioxidants profile of albino rats fed with high fat diet and alcohol. Study Design: This study is a non-randomized experimental study design. Place and Duration of Study: Rivers State University Chemical Pathology Laboratory, Department of Medical Laboratory Science, the study was done between 20th November, 2018-30th June 2019. Methodology: A total number of 45 Wister albino rats were used with the weight ranged from 120-200 grams. The animals were grouped into two major groups, the control Group A and the test Group B. Blood samples were collected via cardiac puncture into heparinized bottle for standard laboratory investigation of lipid profile, and Superoxide dismutase (SOD), Total antioxidant capacity (TAC) and Malondialdehide (MDA). Plasma SOD and MDA were determined using ELISA methods, TAC was determined using FRAP Colorimetric method while lipid profile were determined using enzymatic method. Results: The results revealed that, alcohol induced oxidative stress group exhibited significant differences in MDA levels amongst the groups, and no significance differences in SOD and TAC levels as compared with negative control groups. There were significant differences in the Total Cholesterol and low density lipoprotein levels, amongst the groups. However, these changes appear to improve with coconut water and garlic tincture treatment. Treatment with coconut water alone following 30% alcohol treatment, showed a significant decrease in MDA level, no significant increase in SOD and TAC. Similar observation was recorded for the garlic tincture treatment alone. Treatment with low dose of combined coconut water with garlic tincture following 30% alcohol treatment, shows significant decrease in MDA level, significant increase in SOD, no significant increase in TAC. Treatment with low and higher doses of combined coconut water with garlic tincture following HFD treatment showed similar results, no significant decrease in TG levels, a significant decrease in MDA, TC and LDL levels, a significant increase in TAC and HDL levels and no significant increase in SOD. However, no difference was observed at higher dose. Histological findings revealed changes in hepatocellular architecture, such as inflammatory cell aggregates, dilation of sinosidal space, fatty droplet after treatment with alcohol and high fat diet. However, upon garlic tincture and coconut water treatment, there was amelioration of these abnormalities. Conclusion: The mixture of coconut water and garlic tincture seem to exerted an antioxidant and antiatherogenic effect on alcohol-induced oxidative stress and HFD-induced dyslipidaemia in rats.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Coconut Water and Garlic Tincture on Lipids and Oxidative Profile of Albino Rats Treated with High Fat Diet and Alcohol

Brown

Tamuno-Emine

Sweeten

2021

AJBGMB

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“…Among hundreds of herbs, the common fig (Ficus carica) and garlic (Allium sativum) are widely studied agents. Both are natural herbs with proved hypolipidemic potential [7], [8] but their effect on the TAGs/HDLc ratio is not studied before. As the coronary artery atherosclerosis disease is rising in Pakistan mostly secondary to rising diabetes mellitus prevalence [9] hence there is need to analyze alternative herbal remedies for hyperlipidemia and dyslipidemia.…”

Section: Ficus Carica Allium Sativum Ratsmentioning

confidence: 99%

Comparing potential of Ficus carica and Allium sativum on triglyceride to HDL ratio in high fat diet fed male Wistar Albino rats

Chandio¹,

Memon²,

María³

et al. 2021

Sindh Univ. Res. Jour

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Present study compares the potential of Ficus carica and Allium sativum on triglyceride to HDL ratio in high fat diet fed male Wistar albino rats. A sample of 36 male Wistar albino rats was randomly divided into 6 groups (A, B, C, D, E and F). Hyperlipidemia was induced by high fat diet (HFD) (banaspati ghee + coconut oil) mixed in normal chow diet. After six weeks, blood was taken through retro – orbital capillary plexus, centrifuged to get sera, stored at -20°C temperature for biochemical analysis of blood lipids. TAG/HDLc ratio (atherogenic index of plasma) was measured as log TAG/HDLc. Statistical package (SPSS ver. 21.0, IBM, incorporation, USA) analyzed the results by 1- ANOVA and post – Hoc Benforinni test (p≤ 0.05). Cholesterol, TAGs, LDLc, and HDLc shows significant decrease in F. carica and A. sativum treated experimental groups C – F compared to positive controls (P=0.0001). A. sativum shows more potent hypolipidemic potential and more significant reduction in TAG/HDLc ratio compared to F. carica (P=0.0001). The present study concludes Ficus carica and Allium sativum show hypolipidemic potential with significant decrease in TAG/HDLc ratio and they may be used to prevent atherosclerosis and coronary artery disease as simple home remedy.

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To study the hypotensive and hypolipidemic effects of garlic in smokers in the North Indian population

Cited by 2 publications

References 12 publications

Synergistic Effect of Coconut Water and Garlic Tincture on Lipids and Oxidative Profile of Albino Rats Treated with High Fat Diet and Alcohol

Synergistic Effect of Coconut Water and Garlic Tincture on Lipids and Oxidative Profile of Albino Rats Treated with High Fat Diet and Alcohol

Comparing potential of Ficus carica and Allium sativum on triglyceride to HDL ratio in high fat diet fed male Wistar Albino rats

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