Essential oil from rhizomes ofLigusticum chuanxionginduces apoptosis in hypertrophic scar fibroblasts

Antioxidant and Anti-proliferative Activities of Flavonoids from <i>Bidens pilosa</i> L var <i>radiata</i> Sch Bip

“…The anti-proliferative effect of isolated compounds was measured using the standard MTT assay [18]. In brief, exponentially growing cells (about 1 × 10 5 cells/well) were plated into 96-well plates and allowed to adhere for 24 h prior to extract addition.…”

Resveratrol-Mediated Reduction of Collagen by Inhibiting Proliferation and Producing Apoptosis in Human Hypertrophic Scar Fibroblasts

“…1) Additionally, hypertrophic scarring is a common problem characterized by excessive deposition of ECM, including collagen, and an abnormal invasive growth of fibroblasts 2,3) after deep dermal injuries such as abrasions, burns, and deep donor-site excisions. Previous studies suggest that a delicate balance between cell proliferation and apoptosis plays an important role in the normal wound healing process.…”

Inhibitory effects of essential oil from rhizomes ofLigusticum chuanxiongon hypertrophic scarring in the rabbit ear model

“…The volatile compounds in this herbal drug are considered an important part of its pharmacological effects. In previous investigations, we observed that the EO extracted from RCX markedly inhibited the viability of human hypertrophic scar fibroblasts (HSFs) and elicited cell apoptosis (Wu et al, 2010). The present study was designed to substantiate whether EO could inhibit hypertrophic scarring in the rabbit ear model and to explore the possible mechanism of action.…”

“…The EO was extracted and the GC-MS analysis was performed according to our previous report (Wu et al, 2010). The yield of EO was 0.25% (v/w).…”