Antioxidant and Anti-proliferative Activities of Flavonoids from &lt;i&gt;Bidens pilosa&lt;/i&gt; L var &lt;i&gt;radiata&lt;/i&gt; Sch Bip

Yi, Jun; Wu, Jianguo; Wu, Yuangang; Peng, Wei

doi:10.4314/tjpr.v15i2.17

Cited by 10 publications

(8 citation statements)

References 27 publications

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“…In our assay kaempferol-3- O -glucoside had an EC 50 above 1000 μM, which was beyond the range tested. Yi et al, reported both the activity of quercetin and astragalin, with the quercetin being 18.7 times more active in a cuvette-based DPPH assay [28]. In our assay, this would equate to an approximate EC 50 for kaempferol-3- O -glucoside of 2618 μM which is in agreement with our findings.…”

Section: Resultssupporting

confidence: 91%

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Chromatographic Analysis and Anti-Oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves

et al. 2019

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The Naoxinqing (NXQ) tablet is a standardised proprietary herbal product containing an extract of persimmon leaves (Diospyros kaki) for the management of cardio- and cerebrovascular diseases. Although previous reports suggested that the efficacy of NXQ is at least partly mediated by its anti-oxidative property, the anti-oxidative effect of the major components of NXQ has not been studied systematically. For quality control purposes, only analytical methods limited to 3 marker analytes have been reported, the extent to which the other components affect efficacy has not been explored. In this study, we developed an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC MS/MS) method for the identification of seven analytes (kaempferol-3-O-glucoside (astragalin), quercetin-3-O-galactoside (hypericin), quercetin-3-O-glucoside (isoquercitin), kaempferol, 3,4-dihydroxybenzoic acid (protocatechuic acid), and furan-2-carboxylic acid (pyromucic acid) and quercetin) in the NXQ. This is the first method reported and validated for the quantification of the seven major secondary metabolites in NXQ. The results for the quantified analytes were then compared in 15 different batches of NXQ. The variation observed in the seven components highlights the need to quantify key bioactive components to ensure product consistency. Radical scavenging activity and abundance was used to rank the analytes. The anti-oxidative effects of NXQ were examined using cultured human vascular endothelial cells (EA.hy926). Corrected 2,2-di(4-tert-octylphenyl)-1-picrylhydrazyl (DPPH) activity results revealed that quercetin and kaempferol have the strongest anti-oxidant capacity in the extract. Both quercetin and kaempferol significantly inhibited the hydrogen peroxide (H2O2)-induced EA.hy926 cell injury and intracellular reactive oxygen species (ROS) generation. In conclusion, we established and validated an UPLC-MS/MC method for the analysis of major bioactive components in the NXQ and demonstrated that its anti-oxidative property may play a critical role in cerebrovascular protection.

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Section: Resultssupporting

confidence: 91%

“…The radical scavenging activity of each analyte and sample is reported in Table 5. Kaempferol-3- O -glucoside has reported activity in the DPPH assay [27,28,29]. In our assay kaempferol-3- O -glucoside had an EC 50 above 1000 μM, which was beyond the range tested.…”

Section: Resultsmentioning

confidence: 51%

Chromatographic Analysis and Anti-Oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves

et al. 2019

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“…It was found that the whole-plant water extract inhibited various leukemic cell lines, such as Raji, K562, U937, L1210 and P3HR1, in a concentration-dependent manner [ 15 , 82 ]. As B. pilosa is readily available, Yi et al [ 83 ] suggested that the plant has the potential to be a good health supplement and a resource of natural antileukemic agents.…”

Section: The Anti-leukemic Activity Of Traditional Medicinal Plantsmentioning

confidence: 99%

Medicinal Plants with Anti-Leukemic Effects: A Review

et al. 2021

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Leukemia is a leukocyte cancer that is characterized by anarchic growth of immature immune cells in the bone marrow, blood and spleen. There are many forms of leukemia, and the best course of therapy and the chance of a patient’s survival depend on the type of leukemic disease. Different forms of drugs have been used to treat leukemia. Due to the adverse effects associated with such therapies and drug resistance, the search for safer and more effective drugs remains one of the most challenging areas of research. Thus, new therapeutic approaches are important to improving outcomes. Almost half of the drugs utilized nowadays in treating cancer are from natural products and their derivatives. Medicinal plants have proven to be an effective natural source of anti-leukemic drugs. The cytotoxicity and the mechanisms underlying the toxicity of these plants to leukemic cells and their isolated compounds were investigated. Effort has been made throughout this comprehensive review to highlight the recent developments and milestones achieved in leukemia therapies using plant-derived compounds and the crude extracts from various medicinal plants. Furthermore, the mechanisms of action of these plants are discussed.

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“…column chromatography is also effective in separation of major flavonoid glycosides, astragalin, and isoquercetin in M. oleifera leaves, [15]. Both astragalin and isoquercetin are shown to have antioxidant and anti-proliferative activities [28]. Therefore, the presence of astragalin and isoquercetin in M. oleifera leaf may be responsible for the promising property in chemoprevention.…”

Section: Discussionmentioning

confidence: 99%

Anti-proliferative effect of Moringa oleifera Lam (Moringaceae) leaf extract on human colon cancer HCT116 cell line

Tragulpakseerojn¹,

Yamaguchi²,

Pamonsinlapatham³

et al. 2017

Trop. J. Pharm Res

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Antioxidant and Anti-proliferative Activities of Flavonoids from <i>Bidens pilosa</i> L var <i>radiata</i> Sch Bip

Abstract: 5,6,7,4'-tetramethoxylflavone (4), 5,3',4'-trihydroxy-3,7-dimethoxylflavone (5) and quercetin (6

Cited by 10 publications

References 27 publications

Chromatographic Analysis and Anti-Oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves

Chromatographic Analysis and Anti-Oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves

Medicinal Plants with Anti-Leukemic Effects: A Review

Anti-proliferative effect of Moringa oleifera Lam (Moringaceae) leaf extract on human colon cancer HCT116 cell line

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