Leaf-feeder caterpillars are important soybean pest and widely distributed in the world from tropical to sub-tropical regions, under wet and humid conditions. In Indonesia, these caterpillars attacked 1,316 hectares of soybean crops in the year 2002, and increased to 2,902 hectares in 2006. Therefore, an effective pest control method needs to be identified. An experiment on controlling leaf feeder caterpillars using bio-insecticides SLNPV and SBM, combined with the resistant varieties was conducted at Kendalpayak Experimental Farm of Indonesia Legumes and Tuber Crops Research Institute during dry season of 2016. A strip plot design with three replications was applied, where the vertical factor was varieties i.e. (1) Wilis, (2) Degra 1, and (3) G100H, and insecticides as horizontal factor i.e. (1) without insecticide, (2) 50 g of neemseed flour (SBM) deluted in 1 litre of water, (3) 2 g of SlNPV in 1 litre of water, (4) SBM + SLNPV, and (5) chemical insecticide. Results indicated that SlNPV effectively suppressed the population of caterpillars, as indicated by its lowest numbers. The treatment combination of SBM + SLNPV showed better suppression to the insect than that of chemical insecticide. The role of resistant variety Degra 1 was very important in suppressing the rate of damaged plants, as pointed out by 26% damage reduction as compared to that of susceptible variety Wilis. The effectiveness of leaf feeder caterpillars control was enhanced by combining resistant variety Degra 1 with SLNPV bio-insecticide, resulting 35% of suppression rate, equaled to that obtained by the combination of the resistant variety Degra 1 with chemical insecticide. Degra 1 variety has a potential to be recommended for planting in the endemic area of leaf feeding caterpillars'.