Essential Fatty Acid Studies in Primates
Linolenic Acid Requirements of Capuchins

Fiennes, Richard N. T.-W.; Sinclair, Andrew J.; Crawford, Michael

doi:10.1159/000460319

Cited by 106 publications

(31 citation statements)

References 14 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results gave no evidence of differences in the dietary n-6 and n-3 fatty acids intake between the two groups. Moreover, there was no biochemical indication of dietary linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids or DHA deficiency measured by Mead acid (20:3n-9) [25], the Mead acid/AA ratio [26,27], and docosapentaenoic acid (22:5n-6) in the plasma and red cell CPG. In contrast, others [28,29,30] have shown that GDM have a different fat intake (more saturated fat and less polyunsaturated fat) compared with control subjects.…”

Section: Discussionmentioning

confidence: 96%

Adverse effect of obesity on red cell membrane arachidonic and docosahexaenoic acids in gestational diabetes

et al. 2004

View full text Add to dashboard Cite

Aims/hypothesis. Gestational diabetes is a metabolic disorder affecting 2-5% of women and is a predictor of obesity, Type 2 diabetes mellitus and cardiovascular disease. Insulin resistance, a characteristic of gestational diabetes and obesity, is correlated with the fatty acids profile of the red cell and skeletal muscle membranes. We investigated the plasma and red cell fatty acid status of gestational diabetes. The effect of obesity on membrane fatty acids was also examined. Methods. Fasting blood obtained at diagnosis was analysed for the fatty acids in plasma choline phosphoglycerides and red cell choline and ethanolamine phosphoglycerides.Results. There were reductions in arachidonic acid (controls 10.74±2.35 vs gestational diabetes 8.35±3.49, p<0.01) and docosahexaenoic acid (controls 6.31± 2.67 vs gestational diabetes 3.25±2.00, p<0.0001) in the red cell choline phosphoglycerides in gestational diabetes. A similar pattern was found in the ethanolamine phosphoglycerides. Moreover, the arachidonic and docosahexaenoic acids depletion in the red cell choline phosphoglycerides was much greater in overweight/obese gestational diabetes (arachidonic acid= 7.49±3.37, docosahexaenoic acid=2.98±2.18, p<0.01) compared with lean gestational diabetes (arachidonic acid=10.03±2.74, docosahexaenoic acid=4.18±1.42). Conclusion/interpretation. Apparently normal plasma choline phosphoglycerides fatty acids profile in the gestational diabetic women suggested that membrane lipid abnormality is associated specifically with perturbation in the membrane. The fact that the lipid abnormality is more pronounced in the outer leaflet of the membrane where most of receptor binding and enzyme activities take place might provide an explanation for the increased insulin resistance in gestational diabetes and obesity. [Diabetologia (2004) 47:75-81]

show abstract

Section: Discussionmentioning

confidence: 96%

Adverse effect of obesity on red cell membrane arachidonic and docosahexaenoic acids in gestational diabetes

et al. 2004

View full text Add to dashboard Cite

show abstract

“…The frontal cortex was selected because it is minimally affected by MPTP For example, cold water fatty fi sh, such as salmon and tuna, are among the richest sources of long chain n -3 PUFAs, including eicosapentaenoic acid (EPA: 20:5 n -3) and DHA ( 8,9 ). N -3 and n -6 PUFAs have been considered essential fatty acids ever since the consequences of their defi ciencies on brain development and functions were demonstrated (9)(10)(11). The importance of n -3 PUFAs in maintaining a general health status is widely accepted, as many studies have associated a high n -3 PUFA intake with benefi cial effects on various conditions such as cardiovascular diseases, depression, and Alzheimer's disease [see reviews (12)(13)(14)].…”

Section: Lipid Extraction and Gas Chromatographymentioning

confidence: 99%

Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease

Bousquet

Gue

Émond

et al. 2011

Journal of Lipid Research

View full text Add to dashboard Cite

“…Turning to studies of mammals, it was shown in the 1970s that capuchin monkeys developed symptoms of classical essential fatty acid deficiency while consuming a diet containing 5% corn oil and containing recommended levels of other nutrients [49]. These symptoms included the skin lesions associated with essential fatty acid deficiency and also self-mutilation in some animals and were corrected by adding ·-linolenate to the diet.…”

Section: Animal Studies Of Lc-pufa Functionmentioning

confidence: 99%

Long-Chain Polyunsaturated Fatty Acids

Hamosh¹,

Salem²

1998

Neonatology

View full text Add to dashboard Cite

Long-chain polyunsaturated fatty acids (LC-PUFA) are essential for normal development. Fetal accretion of LC-PUFA occurs during the last trimester of gestation; therefore, premature infants are born with minimal LC-PUFA reserves. Recent studies indicate that the newborn can synthesize LC-PUFA from essential fatty acid precursors; however, the extent of de novo synthesis remains to be established. Postnatally, human milk provides LC-PUFA to the newborn. Maternal LC-PUFA reserves depend upon diet and can be improved by supplementation of docosahexaenoic acid and arachidonic acid during pregnancy and lactation. This in turn affects fetal LC-PUFA accretion and postnatal provision through mother’s milk. Supplementation of formula-fed preterm or full-term infants with docosahexaenoic acid and arachidonic acid leads to plasma and red blood cell LC-PUFA levels similar to those of breast-fed infants. The higher blood and presumably tissue levels of LC-PUFA following supplementation lead, however, to only temporary functional benefits.

show abstract

Essential Fatty Acid Studies in Primates Linolenic Acid Requirements of Capuchins

Cited by 106 publications

References 14 publications

Adverse effect of obesity on red cell membrane arachidonic and docosahexaenoic acids in gestational diabetes

Adverse effect of obesity on red cell membrane arachidonic and docosahexaenoic acids in gestational diabetes

Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease

Long-Chain Polyunsaturated Fatty Acids

Contact Info

Product

Resources

About